Erectile dysfunction (ED) is recognized as one of the complications of diabetes mellitus (DM). To date, a wide gap of knowledge is present on the efficacy of pharmacological treatments of DM on erectile function (EF), acting not only through metabolic control. Similarly, the effects of different diet regimens on ED are still debated.
we aimed to explore the effects of diet and antihyperglycemic drugs, considering both old and novel therapeutic approaches, on EF.
we performed a systematic review, following the PRISMA guidelines. The research was made on studies reporting ED assessment in subjects with diabetes and the relationship with diet and antihyperglycemic drugs.
Mediterranean diet resulted effective in most studies for the protection of EF. Furthermore, antihyperglycemic drugs seem to show overall a protective role on EF.
Although encouraging results are present for all classes of antihyperglycemic drugs, several studies are needed in humans, mainly on acarbose, pioglitazone, dipeptidyl-peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter-2 (SGLT2) inhibitors. This article is protected by copyright. All rights reserved.
Andrology. 2022 Apr 29 [Epub ahead of print]
Giuseppe Defeudis, Rossella Mazzilli, Alfonso Maria Di Tommaso, Virginia Zamponi, Francesco Carlomagno, Dario Tuccinardi, Mikiko Watanabe, Antongiulio Faggiano, Daniele Gianfrilli
Unit of Endocrinology and Diabetes, Department of Medicine, University Campus Bio-Medico di Roma, Rome, Italy., Unit of Endocrinology, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy., Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, 00161, Italy.