We investigated the effect of resveratrol on endothelial and neuronal nitric oxide synthase (eNOS and nNOS) expression in the corpus cavernosum from chronic unpredictable mild stress (CUMS)-exposed rats in order to examine possible role of proinflammatory cytokines, which might play a role on erectile dysfunction (ED). Rats were randomly and equally divided into four groups such as control, control+resveratrol, CUMS and CUMS + resveratrol (20 mg/kg/day, i.p/8 weeks). Sucrose intake and forced swimming tests were used to evaluate depressive-like behaviors. nNOS, eNOS expressions, inflammatory markers, corticosterone and testosterone levels were analyzed either in blood samples and/or penile tissues. CUMS-exposed rats displayed depressive-like behaviors, reduced penile nNOS and eNOS expressions, and serum testosterone levels and enhanced serum and penile tissue levels of proinflammatory markers compared to controls. Resveratrol reversed depressive-like behaviors and suppressed serum and penile levels of proinflammatory markers, increased nNOS and eNOS expressions and testosterone levels in CUMS-exposed rats. Resveratrol exerted antidepressant-like effects and protected the development of CUMS-induced impairment of cavernosal eNOS and nNOS expressions associated with ED, which might be related to its anti-inflammatory action.
International journal of impotence research. 2018 Jul 26 [Epub ahead of print]
Yusufhan Yazir, Tuğçe Demirtaş Şahin, Selenay Furat Rençber, Gulcin Gacar, Zehra Seda Halbutoğulları, Tijen Utkan, Feyza Aricioglu
Kocaeli University, Medical Faculty Department of Histology and Embryology and Stem Cell and Gene Therapy Research and Application Center, Umuttepe Campus-İzmit/Kocaeli, İzmit, 41380, Turkey. ., Kocaeli University, Medical Faculty Department of Histology and Embryology and Stem Cell and Gene Therapy Research and Application Center, Umuttepe Campus-İzmit/Kocaeli, İzmit, 41380, Turkey.