Erectile dysfunction (ED) is a wide spread and troublesome problem in aging men. Many analyses of hypertensive patients suggest that the prevalence of ED in hypertensive populations is even higher. The purpose of this meta-analysis was to evaluate the relation between hypertension and ED. A literature review was performed to identify all cross-section studies about hypertension and erectile dysfunction. Sources included MEDLINE and EMBASE from 1966 to 2015. The reference lists of the retrieved studies were also investigated, and a meta-analysis were conducted. Eighteen cross-section studies involving a total of 41,943 participants and 10,151 cases of ED were used in this analysis. We found that risk of ED was increased with hypertension (summary OR = 1.84, 95% CI: 1.58-2.14, p < 0.000001). Adjusting for obesity, unfavorable lipid levels, alcohol abuse, physical activity, cigarette smoking, educational level and other lifestyle factors, hypertension was also associated with increased risk of ED (summary OR = 1.58, 95% CI: 1.35-1.86, p < 0.00001). The results of this meta-analysis support that hypertension is associated with an increased risk of ED. Further high-quality prospective studies are needed to confirm this observation.
International journal of impotence research. 2018 May 22 [Epub ahead of print]
Xiao-Yan Wang, Wei Huang, Yong Zhang
Beijing Tian Tan Hospital, Capital Medical Univercity, Neurology and Andrology Research Division, China National Clinical Research Center for Neurological Disease, 100050, Beijing, China., Beijing Tian Tan Hospital, Capital Medical Univercity, Neurology and Andrology Research Division, China National Clinical Research Center for Neurological Disease, 100050, Beijing, China. .