Impact of metabolic status on the association of serum vitamin D with hypogonadism and lower urinary tract symptoms/benign prostatic hyperplasia

The objective of this study is to investigate the impact of metabolic status on associations of serum vitamin D with hypogonadism and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH).

A total of 612 men underwent physical examination, biochemical/hormonal blood testing, and transrectal prostate ultrasound. Moreover, the subjects filled out standard questionnaires for identification and grading of LUTS and hypogonadism symptoms. Parameters were statistically compared with independent t-tests and correlation analyses.

Vitamin D levels positively correlated with total testosterone (TT) but not with prostate volume or International Prostate Symptom Score (IPSS). Patients with metabolic syndrome had significantly lower vitamin D levels, which were not correlated with TT, prostate volume, or IPSS. However, vitamin D was positively correlated with TT, and negatively correlated with prostate volume and quality-of-life IPSS in subjects without metabolic syndrome.

The clinical usefulness of vitamin D for treatment of hypogonadism or LUTS/BPH varies according to metabolic status.

The aging male : the official journal of the International Society for the Study of the Aging Male. 2017 Apr 17 [Epub ahead of print]

Sun Gu Park, Jeong Kyun Yeo, Dae Yeon Cho, Min Gu Park

a Department of Preventive Medicine , Gachon University College of Medicine , Incheon , Korea., b Department of Urology , Inje University Seoul Paik Hospital , Seoul , Korea., c Department of Urology , Inje University, Sanggye Paik Hospital , Seoul , Korea.