Benign prostatic hyperplasia (BPH) is the main cause of lower urinary tract symptoms (LUTS) in aging men. As the incidence of prostate cancer (PCa) increases with age, coexistence of BPO and PCa is a frequent issue. Radical prostatectomy might be considered as the best option for patients presenting with severe obstructive symptoms, allowing to simultaneously treat both diseases. However, not all patients are eligible or prefer surgery, therefore a large number of patients are referred to receive PCa radiotherapy (RT). Preexisting LUTS represent a well-known risk factor to develop severe genito-urinary (GU) toxicity. While improving urinary function before starting irradiation appears to be crucial, the development of new minimally invasive surgical therapies (MIST) for BPH creates new opportunities for treatment personalization in RT patients with LUTS.
World journal of urology. 2026 Apr 30*** epublish ***
Jennifer Le Guevelou, Julien Anract, Charles Dariane, Matthijs Scheltema, Rui Bernardino, Lorenzo Bianchi, Veeru Kasivisvanathan, Mattia Sibona, Andrea Mari, Marc Sapoval, Marcin Miszczyk, Pawel Rajwa, Tom Boeken, Giancarlo Marra, YAU Prostate Group
University of medicine François Rabelais, Tours, France. ., Department of Urology, AP-HP, Hôpital Cochin, Université Paris Cité, Paris, France., Department of Urology, Hôpital Européen Georges Pompidou, AP-AP, Paris, France., St. Antonius Hospital, Utrecht, The Netherlands., Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Division of Urology, IRCCS Azienza Ospedaliero-Universitaria di Bologna, Bologna, Italy., Centre for Urology Imaging, Prostate, AI and Surgical Studies (COMPASS) Research Group, Division of Surgery and Interventional Science, University College London, London, UK., Città della Salute e della Scienza e Università degli Studi di Torino, Torino, Italy., Oncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, Florence, 50121, Italy., Department of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, 75015, France., Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.