In this study, we sought to determine the burden and characteristics of orgasmic dysfunction (OD) and concomitant erectile dysfunction (ED) in men with type 1 diabetes (T1D) enrolled in the Epidemiology of Diabetes Interventions and Complications (EDIC) study. In 2010, we assessed orgasmic and erectile function using the International Index of Erectile Function (IIEF). Sociodemographic, clinical, and diabetes characteristics were compared by OD status (OD only, OD and ED, no ED or OD). Age-adjusted associations between risk factors and OD status were examined. OD and ED information was available from 563 men. Eighty-three men (14.7%) reported OD of whom 21 reported OD only and 62 reported OD and ED. Age-adjusted odds ratios demonstrated that men who reported OD only had higher odds of depression, low sexual desire, and decreased alcohol use compared with men reporting no dysfunction. Men with OD concomitant with ED had greater odds of elevated hemoglobin A1C, peripheral and autonomic neuropathy, and nephropathy. Men reporting both dysfunctions were also more likely to report smoking, lower urinary tract symptoms, and had greater odds of androgen deficiency than men with no sexual dysfunction. Men with longstanding T1D suffer from an increased burden of OD. Psychogenic factors predominate in men reporting OD only while men who present with concomitant ED report increased burden of diabetes severity, characteristics previously observed with incident ED. ED may be the central impediment to sexual function in men with OD and ED. Longitudinal studies to characterize OD and ED experience over time are warranted.
International journal of impotence research. 2020 Mar 10 [Epub ahead of print]
Nnenaya Agochukwu-Mmonu, Bahaa S Malaeb, James M Hotaling, Barbara H Braffett, Sarah K Holt, Rodney L Dunn, Melody R Palmer, Catherine L Martin, Alan M Jacobson, William H Herman, Hunter Wessells, Aruna V Sarma, and the DCCT/EDIC Research Group
Department of Urology, University of Michigan, Ann Arbor, MI, USA., Center for Reconstructive Urology and Men's Health, University of Utah, Salt Lake City, UT, USA., The Biostatistics Center, George Washington University, Rockville, MD, USA., Department of Urology and Diabetes Endocrinology Research Center, University of Washington, Seattle, WA, USA., Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., NYU Winthrop Hospital, Research Institute, Mineola, NY, USA., Department of Urology, University of Michigan, Ann Arbor, MI, USA. .