Endothelial nitric oxide synthase gene polymorphisms play a role in some pathophysiological processes. In this study, the possible effects of endothelial nitric oxide synthase gene polymorphisms on ureteral stone disease in patients who were admitted to the emergency department with severe pain due to renal colic are examined.
The study groups were designed as controls and patients. The control group was formed from the healthy volunteers who applied to the blood center next to the emergency service. The patient group comprised patients who were diagnosed with ureteral stone disease with severe pain. All of the genetic studies were based on extracted peripheral blood samples using the necessary procedures from the Genome and Stem Cell Center at Erciyes University (GENKOK). The data were analyzed with SPSS (IBM, ver 20, United Sate).
The study group comprised 62 females and 138 males, and the control group comprised 64 females and 136 males. All of the stones that caused renal colic were found to be localized in the ureters and the ureterovesical junction. The genotypes of the intron 4 polymorphism were found to be as follows: 4a/4a in 10 people, 4b/4a in 115, and 4b/4b in 275 people. The GG genotype of the eNOS-G894T polymorphism was found in 108 patients in the study group and in117 of the healthy individuals. There was no statistically significant difference between the two groups regarding these data.
Although this study is the first in the literature to examine the relationship between renal colic and endothelial nitric oxide synthase gene polymorphisms, our study demonstrated that no relation was found.
The American journal of emergency medicine. 2017 Aug 07 [Epub ahead of print]
Emre Bulbul, Elif Funda Sener, Nahide Ekici Gunay, Bahadir Taslidere, Elif Taslidere, Serhat Koyuncu, Nurullah Gunay
Kayseri Training and Research Hospital, Department of Emergency Medicine, Kayseri, Turkey., Erciyes University, Faculty of Medicine, Department of Medical Biology, Kayseri, Turkey., Kayseri Training and Research Hospital, Department of Clinical Biochemistry, Kayseri, Turkey., Bezmialem Vakif University, Faculty of Medicine, Department of Histology and Embryology, İstanbul, Turkey., Malatya State Hospital, Department of Emergency Medicine, Malatya, Turkey., Gaziosmanpasa University, Faculty of Medicine, Department of Emergency Medicine, Tokat, Turkey. Electronic address: ., Erciyes University, Faculty of Medicine, Department of Emergency Medicine, Kayseri, Turkey.