Urolithiasis is a complex and multifactorial disease with rising global prevalence. Traditional management strategies primarily focus on symptom relief and surgical intervention. However, with advances in genomics, metabolomics, and imaging technologies, precision medicine is reshaping the diagnostic and therapeutic landscape of kidney stone diseases. This review explored the integration of genetic screening, individualized metabolic evaluation, and risk stratification to enable tailored treatment plans. We discuss the current and emerging approaches that align with the principles of precision medicine, including the identification of monogenic and polygenic risk factors, advanced imaging for stone composition, and targeted lifestyle or pharmacological interventions. These developments herald a paradigm shift in urolithiasis care, moving beyond reactive treatment toward proactive, patient-specific management.
Drug metabolism and personalized therapy. 2026 Feb 26 [Epub ahead of print]
Neha Sharma, Joy Das, Utpal Bhui, Biplab Debnath, Mohini Mondal, Rajarshi Nath, Nallapuraju Jahnavi, Shreya Chowdhury, Yogesh Shinde, Navneet Khurana, Bimlesh Kumar, Md Sadique Hussain, Sathvik Belagodu Sridhar, Uttam Prasad Panigrahy, Sumel Ashique, Priya Chaudhary, Mohammad Yousuf Ansari
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Department of Pharmaceutical Technology, Bharat Technology, Uluberia, West Bengal, India., Department of Pharmacy, BGC Trust University, Chittagong, Bangladesh., Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India., RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates., Faculty of Pharmaceutical Science, Assam down town University, Guwahati, Assam, India., Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India., IBNE Seena Pharmacy College, AMES Group of Institutions, Hardoi, Uttar Pradesh, India.