Recent advancements of large language models (LLMs) like Generative Pre-trained Transformer 4 (GPT-4) have generated significant interest among the scientific community. Yet, the potential of these models to be utilized in clinical settings remains largely unexplored. This study investigated the abilities of multiple LLMs and traditional machine learning models to analyze emergency department (ED) reports and determine if the corresponding visits were caused by symptomatic kidney stones.
Leveraging a dataset of manually annotated ED reports, we developed strategies to enhance the performance of GPT-4, GPT-3.5, and Llama-2 including prompt optimization, zero- and few-shot prompting, fine-tuning, and prompt augmentation. Further, we implemented fairness assessment and bias mitigation methods to investigate the potential disparities by these LLMs with respect to race and gender. A clinical expert manually assessed the explanations generated by GPT-4 for its predictions to determine if they were sound, factually correct, unrelated to the input prompt, or potentially harmful. The evaluation includes a comparison between LLMs, traditional machine learning models (logistic regression, extreme gradient boosting, and light gradient boosting machine), and a baseline system utilizing International Classification of Diseases (ICD) codes for kidney stones.
The best results were achieved by GPT-4 (macro-F1=0.833, 95% confidence interval [CI]=0.826-0.841) and GPT-3.5 (macro-F1=0.796, 95% CI=0.796-0.796), both being statistically significantly better than the ICD-based baseline result (macro-F1=0.71). Ablation studies revealed that the initial pre-trained GPT-3.5 model benefits from fine-tuning when using the same parameter configuration. Adding demographic information and prior disease history to the prompts allows LLMs to make more accurate decisions. The evaluation of bias found that GPT-4 exhibited no racial or gender disparities, in contrast to GPT-3.5, which failed to effectively model racial diversity. The analysis of explanations provided by GPT-4 demonstrates advanced capabilities of this model in understanding clinical text and reasoning with medical knowledge.
medRxiv : the preprint server for health sciences. 2024 Aug 13*** epublish ***
Cosmin A Bejan, Amy M Reed, Matthew Mikula, Siwei Zhang, Yaomin Xu, Daniel Fabbri, Peter J Embí, Ryan S Hsi