Calcium-based kidney stone disease is a highly prevalent and morbid condition, with an often complicated and multifactorial aetiology. An abundance of research on the role of specific vitamins (B6, C and D) in stone formation exists, but no consensus has been reached on how these vitamins influence stone disease. As a consequence of emerging research on the role of the gut microbiota in urolithiasis, previous notions on the contribution of these vitamins to urolithiasis are being reconsidered in the field, and investigation into previously overlooked vitamins (A, E and K) was expanded. Understanding how the microbiota influences host vitamin regulation could help to determine the role of vitamins in stone disease.
Nature reviews. Urology. 2023 May 09 [Epub ahead of print]
John A Chmiel, Gerrit A Stuivenberg, Kait F Al, Polycronis P Akouris, Hassan Razvi, Jeremy P Burton, Jennifer Bjazevic
Department of Microbiology & Immunology, Western University, London, Ontario, Canada., Division of Urology, Department of Surgery, Western University, London, Ontario, Canada., Division of Urology, Department of Surgery, Western University, London, Ontario, Canada. .