Objectives To present our large single-center experience in the management of autosomal dominant polycystic kidney disease (ADPKD) with total ultrasound (US)-guided percutaneous nephrolithotomy (PNL) and to evaluate the role of PNL under US in these patients. Patients and methods We retrospectively reviewed the charts of patients with ADPKD who underwent PNL from August 2011 to December 2019. A total of 56 patients were included in this study; all procedures were completed by the total US-guided technique. Demographic characteristics, operative parameters, and postoperative data were collected and analyzed. Results Successful renal access was achieved in all patients. The mean stone size was 3.1 cm (range 1.7-6.5 cm). The initial stone-free rate was 70.6% (36/51); five patients required second-look percutaneous nephrolithotomy to remove residual stones. The other patients underwent oral medication therapy. No severe intraoperative complications occurred; one patient received selective embolization for bleeding on the contralateral side, and one patient needed percutaneous drainage for perinephric abscess. Clavien I or II complications were seen in nine patients. Renal function was improved or stable in most patients; the condition of only one patient deteriorated after surgery. Conclusion Total US-guided PNL is a safe and efficient treatment for kidney stones in patients with ADPKD; perioperative renal function was not adversely affected and complications were acceptable compared with patients in the general population.
Journal of endourology. 2020 Dec 02 [Epub ahead of print]
Bo Xiao, Gang Zhang, Chaoyue Ji, Song Jin, Weiguo Hu, Wenjie Bai, Yuzhe Tang, Jianxing Li
Beijing Tsinghua Changgung Hospital, Urology, No.168 Litang Rd, Changping District, Beijing, Beijing, China, 102218., Beijing Tsinghua Changgung Hospital, Beijing, China; ., Beijing Tsinghua Changgung Hospital, Beijing, China; ., Beijing Tsinghua Changung Hospital, Urology, Beijing, China; ., Beijing Tsinghua Changgung Hospital, Urology, LiTang Road. Changping District, Beijing, China, 102218., Beijing Tsinghua Changgung Hospital, Department of Urology, Beijing, China; ., Department of Urology, Beijing Tsinghua Changgung Hospital. Beijing 102218, China, Beijing, China; ., Beijing Tsinghua Changgung Hospital, Beijing, China; .