Urinary calculi are characterized by high incidence and recurrence rate, which is a challenge in urology. The theory of Randall plaque is widely recognized by scholars. The mechanism of Randall plaque formation includes vascular calcification, osteogenic transformation and so on. However, it still lacks a unified theory for the Randall plaque formation. As an important type of non-coding RNA, long non-coding RNA (lncRNA) is closely related to the occurrence and progress of many diseases. The difference in lncRNA expression between the renal papillary tissues of non-calculous patients and the renal papillary tissues of Randall plaque in renal calculous patients suggests that lncRNA may be involved in the formation of Randall plaque. Pseudoxanthoma elasticum is a rare autosomal recessive hereditary disease, caused by a mutation in the ABCC6 gene. Patients with pseudoxanthoma elasticum have a high prevalence of calculi, and plaque formation is observed in the patient's kidney, which may suggest that mutation in the ABCC6 gene might be involved in the formation of Randall plaque.
泌尿系统结石具有高发病率和复发率的特点，是泌尿外科的难题。Randall斑块学说是目前学者们普遍认可的肾结石形成机制，Randall斑块形成的理论包括血管钙化学说、成骨转化学说等，目前尚未形成统一的学说。长链非编码RNA作为非编码RNA中一个重要的种类，它的突变或失调与疾病的发生和进展关系密切。与非结石患者肾乳头组织相比，肾结石患者肾乳头钙斑处组织中差异表达的长链非编码RNA提示其参与Randall斑块的形成。弹性纤维性假黄瘤是一种罕见的常染色体隐性遗传性疾病，由ABCC6基因突变所致。弹性纤维性假黄瘤患者有较高的结石发病率且肾内可见斑块形成，ABCC6基因缺陷可能促进Randall斑块的形成。.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2020 Apr 28 [Epub]
Yongchao Li, Yang Li
Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China. ., Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China. .