Association of chronic kidney disease stage with 24-hour urine values among patients with nephrolithiasis.

Introduction Nephrolithiasis is a known risk factor for CKD however it is unknown how CKD affects urinary parameters related to stone risk. The purpose of this study was to assess the relationship of diminishing glomerular filtration rate (GFR) and kidney stone related 24-hour urine (24H urine) composition. Materials and Methods A single-institution retrospective review of patients (n=2,057) who underwent 24H urine analysis was performed. The serum creatinine within 1 year of the first 24H urine was used to determine estimated GFR and stratify patients by CKD stage. We performed analysis of variance and multivariable linear regression to assess the relationship of GFR and urinary analytes. Results Among all patients, there were 184 (8.9%), 1,537 (74.7%), 245 (11.9%), 70 (3.4%), 17 (0.8%) and 4 (0.2%) in CKD stage I, II, IIIa, IIIb, IV and V groups respectively. On analysis of 24H urine composition, as CKD increased, changes in urinary parameters protective against crystallization included decreased calcium and uric acid (p <0.001). In addition, parameters favoring crystallization included decreased citrate and magnesium (p = 0.002 and p <0.001 respectively). The net effect with increasing GFR was decreasing supersaturation of calcium oxalate and phosphate. On linear regression, urinary excretion of calcium, oxalate, citrate, uric acid, phosphate and ammonia all decreased with decreasing GFR (all p < 0.05). Conclusions Higher CKD stage was associated with changes in urinary analytes that both promoted and inhibited stone formation, with the net effect of decreasing calcium oxalate and phosphate supersaturation. These patients may benefit from medical therapy that targets improving urinary citrate instead of lowering calcium or uric acid.

Journal of endourology. 2020 Jun 24 [Epub ahead of print]

Wilson Sui, Joshua Calvert, Nicholas Kavoussi, Edward R Gould, Nicole Miller, Cosmin Bejan, Ryan Hsi

Vanderbilt University Medical Center, 12328, 2010 Convent Place, Nashville, Nashville, Tennessee, United States, 37232-2102; ., Vanderbilt University Medical Center, 12328, Urology, Nashville, Tennessee, United States; ., Vanderbilt University Medical Center, 12328, Urology, 1211 Medical Center Drive, Nashville, Tennessee, United States, 37323; ., Vanderbilt University Medical Center, 12328, Medicine, Division of Nephrology, Nashville, Tennessee, United States; ., Vanderbilt University Medical Center, 12328, Urology, A-1302 MCN, Nashville, Tennessee, United States, 37232; ., Vanderbilt University Medical Center, 12328, Department Biomedical Informatics, Nashville, Tennessee, United States; ., Vanderbilt University Medical Center, 12328, Urology, 1161 21st Ave South, Nashville, Tennessee, United States, 37232; .