Urinary stone disease during pregnancy is poorly understood but is thought to be associated with increased maternal and fetal morbidity. We sought to determine the prevalence of urinary stone disease in pregnancy and whether urinary stone disease during pregnancy is associated with adverse pregnancy outcomes.
We identified all pregnant women from 2003 through 2017 in the Optum national insurance claims database. We used diagnosis claims to identify urinary stone disease and assess medical comorbidity. We established the prevalence of urinary stone disease during pregnancy, stratified by week of pregnancy. We further evaluated associations among urinary stone disease and maternal complications and pregnancy outcomes in both univariable and multivariable analyses.
Urinary stone disease affects 8/1000 pregnancies and is more common in white women and women with more comorbid conditions. In fully adjusted models, pregnancies complicated by urinary stone disease had higher rates of adverse fetal outcomes, including prematurity and spontaneous abortions. This analysis is limited by its retrospective administrative claims design.
The rate of urinary stone disease during pregnancy is higher than previously reported. Urinary stone disease is associated with adverse pregnancy outcomes.
The Journal of urology. 2019 Nov 18 [Epub ahead of print]
Ericka M Sohlberg, William D Brubaker, Chiyuan Amy Zhang, Leander D L Anderegg, Kai Dallas, Shen Song, Calyani Ganesan, Glenn Chertow, Alan Pao, Joseph Liao, John T Leppert, Christopher S Elliott, Simon L Conti
Department of Urology, Stanford University School of Medicine, Stanford, California., Department of Integrative Biology, University of California at Berkeley, Berkeley, California., Division of Nephrology, Stanford University School of Medicine, Stanford, California.