Endoscopic management of upper-tract urothelial carcinoma

Radical nephroureterectomy with an ipsilateral bladder cuff is the referent standard for management of muscle-invasive, high-grade, or bulky upper-tract urothelial carcinoma (UTUC). Nonetheless, certain patients with UTUC have imperative or elective indications for kidney preservation thereby lending to more conservative strategies for management of this disease. Areas covered: A review of the PubMED and Medline databases was performed to identify original scientific and review articles discussing retrograde ureteroscopic or percutaneous antegrade resection of UTUC tumors published between 1995 and 2016. Comparative studies with radical nephroureterectomy were also included. Expert commentary: Endoscopic ablative treatments via retrograde or antegrade approaches may appropriately treat small, solitary, and low risk UTUC tumors. Recurrences in the ipsilateral upper-tract and bladder distal to the original tumor can occur following nephron-sparing treatments and therefore a vigilant surveillance program with a compliant patient is essential when pursuing this treatment approach.

Expert review of anticancer therapy. 2017 May 15 [Epub]

Jay D Raman, Rosa Park

a Division of Urology , Penn State Health Milton S. Hershey Medical Center , Hershey , PA , USA.

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe