The Role of Prophylactic Antibiotics after Minimally Invasive Pyeloplasty with Ureteral Stent Placement in Children

To determine whether children discharged with prophylactic antibiotics following laparoscopic pyeloplasty with indwelling ureteral stent have a decrease risk of postoperative urinary tract infections compared to those discharged without antibiotics.

A retrospective review of all minimally invasive pyeloplasties performed at our institution from January 2009 - March 2015 was conducted. Patients were discharged home with or without daily prophylactic-dose antibiotics continued until three days after ureteral stent removal per surgeon preference. The primary outcome was incidence of culture positive urinary tract infection. Secondary outcomes included bacteriuria at time of stent removal and adverse events associated with extended antibiotic therapy.

Of 163 pyeloplasties (106 robotic and 57 pure laparoscopic) performed over the study period, 126 patients were discharged on prophylactic antibiotics while 37 patients were discharged without prophylaxis. Groups were different with respect to median age (7. 1 vs. 12. 0 years, p = 0. 03) and median duration of ureteral stent (35 days vs. 28 days, p = 0. 02). The incidence of culture positive urinary tract infection between the time of discharge and stent removal was comparably low between groups, 2/126 (1. 6%) in the prophylaxis group and 1/37 (2. 7%) in the group not on prophylaxis. At time of stent removal, perioperative urine culture was positive in 2/20 (10. 0 %) patients who received prophylactic antibiotics and in 1/25 (4. 0%) patients who did not (p=0. 54).

The administration of extended prophylactic antibiotics showed no significant impact on the rate of urinary tract infection following minimally invasive pyeloplasty.

Urology. 2015 Dec 09 [Epub ahead of print]

Matthew C Ferroni, Timothy D Lyon, Kevin J Rycyna, Moira E Dwyer, Francis X Schneck, Michael C Ost, Glenn M Cannon, Heidi A Stephany

Department of Urology, University of Pittsburgh, Pittsburgh, PA. Department of Urology, University of Pittsburgh, Pittsburgh, PA. , Department of Urology, University of Pittsburgh, Pittsburgh, PA. , Department of Urology, University of Pittsburgh, Division of Pediatric Urology, Children's Hospital of Pittsburgh, Pittsburgh, PA. , Department of Urology, University of Pittsburgh, Division of Pediatric Urology, Children's Hospital of Pittsburgh, Pittsburgh, PA. , Department of Urology, University of Pittsburgh, Division of Pediatric Urology, Children's Hospital of Pittsburgh, Pittsburgh, PA. , Department of Urology, University of Pittsburgh, Division of Pediatric Urology, Children's Hospital of Pittsburgh, Pittsburgh, PA. , Department of Urology, University of Pittsburgh, Division of Pediatric Urology, Children's Hospital of Pittsburgh, Pittsburgh, PA.

PubMed

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