Rezūm water vapor thermal therapy is a minimally invasive surgical option with demonstrated efficacy and safety. However, real-world evidence on 2-year outcomes in the population aged above 80 years remains limited.
A prospective registry was created as part of the International Rezūm Registry database at two high-volume centers. Data were reviewed from patients monitored between April 2019 and August 2024. Men aged ≥ 80 years who underwent Rezūm therapy were included. Baseline and follow-up assessments at 3, 6, 12, and 24 months included International Prostate Symptom Score (IPSS), IPSS Quality of Life (QoL) subscore, peak urinary flow rate (Qmax), and post-void residual volume (PVR). Safety outcomes and adverse events were also recorded.
Fifty-eight patients (mean age 84.4 ± 4.4 years) were included, with a mean prostate volume of 80.1 ± 42.1 cc. The mean IPSS decreased from 19.8 ± 7.4 at baseline to 12.4 ± 7.9 at 24 months. The IPSS quality of life (QoL) score declined from 4.2 ± 1.8 at baseline to 2.6 ± 1.5 at the corresponding follow-up interval. Qmax improved from 8.5 ± 5.8 mL/s at baseline to 15.0 ± 4.0 mL/s at 24 months, respectively. PVR was reduced from 115.5 ± 93.7 mL at baseline to 42.8 ± 29.2 mL over the same period. However, neither Qmax nor PVR demonstrated a statistically significant change at any time point. Adverse events were infrequent, with urinary tract infections (8.6%), epididymitis (5.2%), and acute urinary retention (3.4%). Only one patient required hospitalization.
Rezūm water vapor thermal therapy is a safe and effective treatment for BPH in patients over 80 years of age. It results in durable improvements in urinary symptoms and function with a low rate of complications.
Lower urinary tract symptoms. 2026 Jan [Epub]
Mario Henrique Bitar Siqueira, Sagi Shprits, Naeem Bhojani, Bilal Chughtai, Kevin C Zorn, Luca Cindolo, Giovanni Ferrari, Katherine Lajkosz, Dean Elterman
Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada., Division of Urology, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Canada., Plainview Hospital, Smith Institute of Urology, Northwell Health, Syosset, New York, USA., BPH Canada, Prostate Surgical Institute, Montreal, Canada., Urology Department, Hesperia Hospital, CUrE Group, Modena, Italy., Department of Biostatistics, University Health Network, Toronto, Ontario, Canada.