Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study.

Robot-assisted radical cystectomy (RARC) optimizes patient recovery and has outcomes comparable with those of open surgery. This study aimed to compare the perioperative and oncologic outcomes of RARC in female and male patients.

A retrospective cohort study of the Korean Robot-Assisted Radical Cystectomy Study Group database from 2007 to 2019 identified 749 patients (111 females and 638 males). Female were matched 1:1 to male by propensity score matching using a logistic regression. We compared perioperative outcomes, oncologic outcomes, and complications between the two groups.

The female group had comparable perioperative outcomes to the male group in terms of operation time, lymph node yield, positive surgical margin, blood transfusion rate, and hospitalization days. Complication rate and grade were not significantly different between the two groups. The most common complication was infection in female and gastrointestinal complications in male. We compared the 5-year overall, disease-specific, and recurrence-free survival of female and male: 58.2% vs. 68.0% (p=0.495), 75.7% vs. 79.3% (p=0.645), and 40.8% vs. 53.5% (p=0.913), respectively. On multivariable analysis, T stage (>T2), postoperative complications, and positive surgical margin were prognostic factors of poor outcome. Sex was not an independent predictor of the three survivals.

The current study suggests that RARC in female has comparable perioperative and oncologic outcomes to those in male. The complication rate of RARC in female was comparable to that in male, but the type of complications differed by sex.

Investigative and clinical urology. 2022 Jan [Epub]

Hyun Jung Jin, Ji Sung Shim, Tae Gyun Kwon, Tae-Hwan Kim, Seung Hyun Jeon, Sang Hyub Lee, Sung Gu Kang, Jong Kil Nam, Wan Suk Kim, Byung Chang Jeong, Jong Jin Oh, Sang Chul Lee, Ji Youl Lee, Sung-Hoo Hong, Koon Ho Rha, Woong Kyu Han, Won Sik Ham, Young Goo Lee, Yong Seong Lee, Sung Yul Park, Young Eun Yoon, Ja Hyeon Ku, Seok Ho Kang

Department of Urology, Korea University College of Medicine, Seoul, Korea., Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea., Department of Urology, KyungHee University College of Medicine, Seoul, Korea., Department of Urology, Busan National University Yangsan Hospital, Yangsan, Korea., Department of Urology, Inje University Busan Paik Hospital, Busan, Korea., Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea., Department of Urology, Seoul National University College of Medicine, Seoul, Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea., Department of Urology, Yonsei University College of Medicine, Seoul, Korea., Department of Urology, Hallym University School of Medicine, Seoul, Korea., Department of Urology, Hanyang University College of Medicine, Seoul, Korea., Department of Urology, Seoul National University College of Medicine, Seoul, Korea. ., Department of Urology, Korea University College of Medicine, Seoul, Korea. .

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