Water vapor therapy (Rezūm) for lower urinary tract symptoms related to benign prostatic hyperplasia: early results from the first Italian multicentric study.

Rezūm is the latest developed minimally invasive treatment for benign prostatic hyperplasia (BPH). We aimed to carefully assess the functional outcomes of patients treated with Rezūm for BPH.

We prospectively followed 135 consecutive patients treated by Rezūm at 5 institutions from June 2019 to August 2020. The International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI SF), the Overactive Bladder Questionnaire-Short Form (OAB-q SF) score, the International Index of Erectile Function (IIEF-5) and questions 9 and 10 to assess ejaculatory dysfunction were recorded. Election criteria were age > 18, no prior prostate interventions, IPSS ≥ 13, post-void residual ≤ 250 mL, prostate volume between 30 and 120 cc.

The median operative time was 10.5 (IQR 8.7-15) min. All patients were dismissed few hours after surgery with indwelling urinary catheter that was removed after a median of 7 (IQR 7-10) days. A significantly decrease of IPSS from baseline at first (p = 0.001) and third (p < 0.0001) month after surgery was reported. No difference was reported in terms of ICIQ-UI SF score postoperatively. A mild reduction of the OAB-q SF score was reported at 1 month from surgery (p = 0.06) that turned significant at 3 months postoperatively (p < 0.0001). A slight but statistically significant increase of the IIEF-5 score was reported from baseline at 6 months (p = 0.04). Postoperatively, patients reported a significantly decrease of ejaculatory dysfunction after alpha-blocker interruption.

Rezūm treatment is a feasible minimally invasive option for patients with BPH symptoms and showed optimal early functional outcomes.

World journal of urology. 2021 Mar 31 [Epub ahead of print]

Giampaolo Siena, L Cindolo, G Ferrari, D Maruzzi, G Fasolis, S V Condorelli, F Varvello, F Visalli, S Rabito, S Toso, S Caroassai, A Mari, L Viola, B K Somani, M Carini

Department of Urology, Careggi Hospital, University of Florence, San Luca Nuovo, Florence, Italy. ., Department of Urology, Villa Stuart, Private Hospital, Rome, Italy., Department of Urology, Hesperia Hospital, Cure Group, Modena, Italy., Department of Urology, S. Maria Degli Angeli Hospital, Pordenone, Italy., Department of Urology, Michele e Pietro Ferrero Hospital, Alba-Bra, Italy., Department of Urology, Vittorio Emanuele Hospital, Gela, Italy., Department of Urology, Careggi Hospital, University of Florence, San Luca Nuovo, Florence, Italy., University Hospital Southampton NHS Trust, Tremona Road, Southampton, SO16 6YD, Hampshire, UK.