To examine serum paraoxonase 1 and 3 activities in benign and malignant diseases of the prostate, and changes in levels following robotic-assisted laparoscopic radical prostatectomy.

To examine serum paraoxonase 1 and 3 (PON1 and PON 3) activities in benign and malignant diseases of the prostate, to determine lipid profile and malondialdehyde (MDA) levels, and to investigate changes in levels following robotic-assisted laparoscopic radical prostatectomy (RALRP).

137 patients, including a control group, were enrolled in the study. These were assigned into four groups. Group 1 (n=33) consisted of previously undergoing RALRP with no recurrence, Group 2 (n=36) of patients diagnosed with prostate cancer (PCa) and undergoing RALRP, and Group 3 (n=34) of patients diagnosed with benign prostatic hyperplasia. The control group (n=34) consisted of healthy individuals. Serum Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), triglyceride, cholesterol, prostate-specific antigen (PSA), PON1, PON3, and MDA values were measured. In addition, Group 2 MDA, PON1, PON3, and PON1/HDL levels were investigated preoperatively and at the first month postoperatively.

Significant changes were determined in PON1, PON3 and MDA levels. PON1 and PON3 levels decreased significantly in patients with PCa, while MDA levels increased. PON1 and PON3 increased postoperatively in the PCa group, while MDA decreased. BPH group PON1, PON3 and MDA levels were higher than those of the control group.

An increase in free oxygen radicals in the body or a decrease in endogenous antioxidant enzyme levels can result in malignant and benign diseases of the prostate. Surgical excision of malignant tissue in PCa causes a decrease in oxidative stress.

Turkish journal of medical sciences. 2020 Jun 18 [Epub ahead of print]

Fevzİ Bedİr, HÜseyİn KocatÜrk, Mehmet Sefa Altay, Engİn Şebİn, Banu Bedİr