Uroalerts Men's Health Weekly

December 02, 2025

Videos

Peer-to-Peer Clinical Conversations

Phase 2 ALPACA Trial Evaluates Avelumab in Advanced Penile Cancer - Srikala Sridhar

Srikala Sridhar

Srikala Sridhar joins Zachary Klaassen to discuss the ALPACA trial evaluating avelumab in advanced penile cancer.

Preoperative Urinary Retention and Its Effect on HoLEP Surgery Outcomes - Diana Lopategui

Alan Wein hosts Diana Lopategui to present a retrospective database analysis examining whether chronic urinary retention severity impacts HoLEP outcomes.

Beyond the Abstracts

Peyronie's Disease and Risk of Depression. A Nationwide 25-Year Cohort Study - Beyond the Abstract

Comparative Utility of Urethrosonography Versus Classic Techniques in Diagnosing Urethral Stricture: A Single Center Study - Beyond the Abstract

Post-Procedural Urethral Strictures after Aquablation - Beyond the Abstract

Articles

Editor Selected Abstracts and Commentaries

Male Infertility

Small RNA sequencing in individually selected sperm: Biomarkers for male subfertility and predictors of pregnancy success.

Timing Matters? Impact of Early Sperm Processing on Motile Sperm Recovery, Fertilization, Blastocyst Rate, and Pregnancy Outcomes in IUI and IVF.

The Combined Expression Profiles of Epigenetic Biomarkers Reveal Heterogeneity in Normospermic Human Sperm Samples.

Is the TEX11-.652del237bp Exonic In-Frame Deletion Variant Associated with Azoospermia? The Results of an In Vitro and In Silico Study.

Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men.

Peyronie's Disease

Rethinking the peyronie's disease questionnaire: a perspective on inclusivity in sexual health assessment.

Erectile Dysfunction

De novo erectile dysfunction after first myocardial infarction: systematic review and meta-analysis.

Evaluating the appropriateness of penile prosthesis in non-organic erectile dysfunction and premature ejaculation: a Delphi consensus among penile implant surgeons.

Visualization and Optical Manipulation of the Erectile Tissue, Penile Corpus Cavernous.

A critical analysis of the methodological limitations in trials of low-intensity shockwave therapy for erectile dysfunction.

BPH - Benign Prostatic Enlargement

Catheter-Dependent Patients Undergoing GreenLight Laser Photoselective Vaporisation of the Prostate: A Retrospective Observational Study of Postoperative Catheter-Free Outcomes.

Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia.

Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells.

Comparative Effectiveness and Safety of Finasteride and Dutasteride in the Treatment of Benign Prostatic Hyperplasia: A Real-World Retrospective Study.

Penile & Urethral Cancers

Penile Cancer Treatments and Their Psychiatric Sequelae: A National Analysis.

Histology-Specific Survival in Penile Squamous Cell Carcinoma: A SEER-Based Study Highlighting Human Papillomavirus Status and Prognostic Subtypes.

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines.

A call for raising public awareness and improving outcomes of penile cancer.

Functional and surgical outcomes after penile surgery for cancer: Comparison between conservative and non-conservative surgery.

Testicular Cancer

Late relapse of testicular germ cell tumor: An individual patient data meta-analysis of disease characteristics, treatments, and oncological outcomes.

Spatial patterns of testicular cancer diagnosis in Australia, 2010-2019.

Prostate Cancer

Comparison of same-day discharge robotic-assisted radical prostatectomy in an ambulatory surgery center versus hospital setting.

A Computational Pathology Model to Predict Docetaxel Benefit in Localized High-Risk and Metastatic Prostate Cancer.

Automated imaging as an adjunct to serum and clinical biomarkers: a new validated prediction tool for metastatic castration-resistant prostate cancer.

Radical Prostatectomy Combined with Prostate Specific Membrane Antigen-radioguided Lymph Node Dissection is Associated with Longer Treatment-free Survival for Patients with Primary Lymph Node-positive Prostate Cancer.

Real-World Medical Device Reports of SpaceOAR Hydrogel Spacer: Analysis of the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) Database.

Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion.

Extending Current Guideline-recommended Prostate-specific Antigen Density Thresholds for Improving Benefit/Harm Balance in Risk-based Magnetic Resonance Imaging-directed Prostate Cancer Diagnosis, from the Community-based Multicentre MR-PROPER Study.

Rapid Eradication of Extensive Spinal Metastases in a Prostate-Cancer Patient Taking Androgen-deprivation Therapy, Chemotherapy, and Oral Recombinant Methioninase on a Low-Methionine Diet.

Comprehensive Outcome Analysis of Single-Port Robot-Assisted Radical Prostatectomy.

External beam radiotherapy for prostatic cancers: 2025 update.

Micro-ultrasound for prostate cancer.

Preventative cancer screening among African and Afro-Caribbean immigrants.

Primary Staging of Intermediate- and High-Risk Prostate Cancer Using [18F]PSMA-1007 PET/CT and [18F]NaF PET/CT: A Head-to-Head Comparison of Diagnostic Accuracy, Staging, and Patient Management.

Radiation Reprograms Fibroblasts to Drive Prostate Cancer Therapy Resistance.

Prognostic significance of magnetic resonance imaging-detected extraprostatic extension in localized prostate cancer.

Population Pharmacokinetics Analysis of Talazoparib and Enzalutamide Combination Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer.

Rethinking Gleason pattern quantification in predicting metastasis: results of 20 years of follow-up in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer.

PuraBond® in Robot-Assisted Radical Prostatectomy (RARP): Exploring a Novel Haemostatic Strategy Using Self-Assembling Peptides.

NUAK2 is a therapeutically tractable regulator of RNA splicing and tumor progression in neuroendocrine prostate cancer.

Gleason Score 3 + 4 (Grade Group 2) Prostate Cancer on Biopsy and Postoperative Pathological Upgrading: A Systematic Review and Meta-Analysis.

[18F]Flotufolastat PET/MRI in Patients with Suspected Prostate Cancer: Correlation with Histopathologic Biopsy Results.

Targeting FZD6 creates therapeutically actionable vulnerabilities for advanced prostate cancer.

Incidental findings on prostate MRI in a population-based screening setting.

Molecular tumor volume on PSMA PET/CT is an independent imaging biomarker associated with progression-free survival in patients with oligorecurrent prostate cancer.

From lutetium to terbium: a new era in PSMA-targeted radioligand therapy for mCRPC patients.

Can Prostate Cancer Screening Reduce Mortality in Men Aged 75-79 Years? A Protocol for Target-trial Emulation.

Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program.

EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of m6A autoregulation pathway.

Perioperative Outcomes Comparing the DaVinci 5 with DaVinci Xi in Patients Undergoing Robotic-Assisted Radical Prostatectomy - Beyond the Abstract

Reappraisal of Neuroendocrine Tumor Classification of the Prostate Gland: Translating Molecular Insights into Clinical Practice - Beyond the Abstract

Single-Arm Investigator-Initiated Clinical Trial to Improve Germline Testing in At-Risk Patients With Prostate Cancer (IMPRINT).

Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer.

Apalutamide in Patients with High Burden of Metastatic Hormone-sensitive Prostate Cancer: A Subgroup Analysis of TITAN.

Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities.

Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus.

The Legacy of Chattel-Slavery and Its Association with Prostate Cancer Incidences in the Southeastern US.

USP21/YBX1/HIF1-α promotes the progression of prostate cancer.

DARolutamide ObservationaL (DAROL) study in patients with nonmetastatic castration-resistant prostate cancer: prespecified third interim analysis.

Age and Treatment Intensification in Metastatic Hormone-Sensitive Prostate Cancer.

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