Uroalerts Men's Health Weekly

October 21, 2025

Videos

Peer-to-Peer Clinical Conversations

Randomized Trial of NeuroSAFE Technique in Radical Prostatectomy for Erectile Function - Eoin Dinneen & Ricardo Almeida-Magana

Eoin Dinneen

Ricardo Almeida-Magana and Eoin Dinneen share NeuroSAFE PROOF trial results with Zachary Klaassen, presenting the first randomized controlled trial demonstrating improved erectile function after radical prostatectomy.

Surgical Treatment Options for Stable Peyronie's Disease - Laurence Levine

Laurence Levine

Laurence Levine reviews surgical algorithms for stable Peyronie's disease, establishing surgery as gold standard achieving 90%+ functional straightness defined as ≤20 degrees residual curvature.

Conference Coverage

ESMO 2025: Patient Reported Outcomes from AMPLITUDE, a Trial of Niraparib and Abiraterone Acetate plus Prednisone in mHSPC with Homologous Recombination Repair Mutations

ESMO 2025: Discussion: Long-Term SAKK 01/10 Seminoma Outcomes and the ALPACA Avelumab Study

ESMO 2025: A Phase 2 Study of Avelumab in Locally Advanced or Metastatic Penile Cancer Patients Unfit for Platinum-Based Chemotherapy or Progressed on or after Platinum-Based Chemotherapy (ALPACA)

ESMO 2025: Translational Analyses of T-Cell Phenotypes and Their Association with Clinical Efficacy in the First-in-Human (FIH) Trial of JNJ-78278343 (Pasritamig) in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

ESMO 2025: Single-Dose Carboplatin and Involved-Node Radiotherapy for Seminoma Stage IIA/B: Long-Term Follow-up from the International Multicenter Phase II Trial SAKK 01/10

Articles

Editor Selected Abstracts and Commentaries

Male Infertility

Integrated profiling of semen microbiota and metabolome reveals dysregulation in primary idiopathic male infertility.

Distinct post-insemination dynamics between fresh and frozen-derived gametes using testicular sperm.

Epididymitis promotes formation of tertiary lymphoid organs in the cauda epididymidis.

The effect of obesity interventions on male fertility: a systematic review and meta-analysis.

Erectile Dysfunction

Infection rates and risk factors following inflatable penile prosthetic implantation: an analysis of real-world hospital data.

Insomnia and Benzodiazepine Use as Risk Factors for Erectile Dysfunction: Clinical Evidence and In Silico Analysis of Physicochemical Properties.

Erectile Dysfunction Drugs as Potential Therapy for Cognitive Decline: Preclinical and Translational Evidence.

Association between the inflammatory burden index and erectile dysfunction: a cross-sectional study based on NHANES 2001-2004.

BPH - Benign Prostatic Enlargement

Efficacy of Hexanic Serenoa repens Extract Combined With Alfuzosin Versus Alfuzosin Alone in Men With Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Multicenter Randomized Study.

Pilot health education programme for patients undergoing transurethral resection of the prostate.

Thulium fiber laser enucleation of the prostate (ThuFLEP) for the treatment of benign prostatic obstruction: a comparative study of men with prostate volumes ≥ 150 mL and

Intravesical prostatic protrusion volume: effect on lower urinary tract symptoms and urinary flow in patients with benign prostatic enlargement.

Assessment of the validity of ChatGPT-3.5 responses to patient-generated queries following BPH surgery.

Penile & Urethral Cancers

Navigating Penile Metastases: Personalized Management in a Rare Oncologic Challenge.

Magnetic sentinel node biopsy with Sienna+®/SentiMag® in penile squamous cell carcinoma: Case report.

Testicular Cancer

Insights From Testicular Cancer Deaths in the U.S. Military: Case Reports.

Prostatic Metastasis of Bilateral Metachronous Testicular Cancer: A Case Report and Review of the Literature.

Epidemiological patterns, temporal trends in management and long-term outcomes in testicular cancer: a 30-year single center experience.

Immunohistochemical Expression of Nectin-4 and Potential Implications for Enfortumab Vedotin Therapy in Germ Cell Tumors of the Testis: A Preliminary Study - Beyond the Abstract

Prostate Cancer

UK real-world data of radium-223 dichloride in metastatic prostate cancer.

Time and cost burden associated with docetaxel in patients with metastatic castration-sensitive prostate cancer initiating an androgen receptor pathway inhibitor-based regimen.

Experiences of metastatic prostate cancer patients with a mainstream genetic testing pathway.

The Conundrum of Intermediate Risk in Localised Prostate Cancer: One Group, Many Realities.

Informing the development of a nurse-led survivorship intervention for men with prostate cancer treated with androgen deprivation therapy: A qualitative exploratory study.

A Social Media Campaign and Web-Based Survey About Prostate Cancer Genetics: Mixed Methods Study.

Real-world treatment patterns and survival outcomes in patients with metastatic castration-resistant prostate cancer in France: lessons from the prospective OPALE study.

Experience of uncertainty in prostate cancer: A qualitative study.

Differences in prostate cancer treatment receipt and timeliness of treatment between African American/Black and White Iowans.

Oncological outcomes after tailored PSMA-PET-guided treatment in biochemical relapse after prostatectomy (PSICHE Trial-NCT 05022914).

Liquid biopsy identifies taxane resistance and clonal selection in castration-resistant prostate cancer.

Readability of Prostate Cancer Patient Education Materials: A Comprehensive Assessment Using Readability Metrics.

Utility of MRI perilesional biopsy in prostate cancer: impact of the Prostate Imaging-Reporting and Data System and biopsy history.

Prediction of Metastasis-Free Survival in Patients with Localized Prostate Adenocarcinoma Using Primary Tumor and Lymph Node Radiomics from Pre-Treatment PSMA-PET/CT Scans - Beyond the Abstract

Integrating systemic therapy and metastasis-directed therapy in oligometastatic hormone-sensitive prostate cancer.

IP8-FLUORESCE: A Prospective Paired Cohort Study Evaluating the Diagnostic Accuracy of Fluorescence Confocal Microscopy for Real-time Assessment of Surgical Margins in Radical Prostatectomy.

Understanding Management Strategies for Metastatic Hormone-Sensitive Prostate Cancer: A Multidisciplinary Survey in France.

Barriers and Facilitators of Treatment Intensification in Metastatic Castration-Sensitive Prostate Cancer.

MUlticentre REtrospective Comparison of Definitive EBRT with or Without HDR BRAchytherapy Boost in Patients with Locally-Advanced Prostate Cancer and Regional Lymph NOde Metastases (MUREBRANO) - a Propensity Score Matched Analysis - Beyond the Abstract

A Prospective Provincial Registry of 18F-PSMA PET/CT for Recurrent Prostate Cancer: Results for 4,135 Men - Beyond the Abstract

Predictors of Toxicities and Oncological Outcomes Following Postoperative Ablative Radiotherapy (POPART) for Biochemical Recurrence - Beyond the Abstract

Implementation of a biparametric prostate MRI protocol with a recall system for intravenous contrast: an analysis of recall rates and comparison of PI-RADS category distribution.

Androgen receptor pathway signaling inhibitors in development for prostate cancer therapy.

Novel MRI-US fusion with advanced annotation in focal cryoablation for prostate cancer: medium-term outcomes and learning curve insights.

Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair.

Adverse in-hospital outcomes in patients with paraplegia who undergo radical prostatectomy.

Prognostic Implications of Very High Decipher Scores in Prostate Cancer: Towards a Refined Genomic Risk Classification.

An opportunity to save? SBRT is less costly than IMRT for intermediate-risk prostate cancer.

Use of staging in intermediate-risk prostate cancer: A real-world data analysis.

Prognostic Value of Initial Imaging and PSA Change with [177Lu]Lu-PSMA-617 Radiopharmaceutical Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A ProsTIC Registry Analysis.

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