UroAlert - GU Oncology Weekly

January 29, 2026

Videos

Peer-to-Peer Clinical Conversations

A Split-Function Approach to Estimate Post-Surgical Kidney Health in Upper Tract Urothelial Carcinoma - Kieran Lewis

Kieran Lewis

Kieran Lewis presents a parenchymal volume-based model (PVA+) predicting GFR after nephroureterectomy to guide chemotherapy timing in upper tract urothelial carcinoma.

IBCG Recommendations for Intermediate-Risk NMIBC Definitions and Management - Roger Li

Roger Li

Roger Li discusses the International Bladder Cancer Group recommendations for intermediate-risk non-muscle invasive bladder cancer.

Beyond the Abstracts

Cambridge kidney One-Stop Mass Investigation Clinic (CkOSMIC): A Nonrandomised Feasibility Study - Beyond the Abstract

Robot-Assisted Radical Nephroureterectomy for Locally Advanced Upper Tract Urothelial Carcinoma: A Multicenter Study by the Junior ERUS/YAU Working Group on Robot-Assisted Surgery - Beyond the Abstract

Conference Coverage

SUO 2025: PROSTest, a Novel Blood-based mRNA Assay, Can Accurately Predict Outcomes to 177Lu-PSMA in Metastatic Castration Resistant Prostate Cancer

ESMO 2025: De-escalation Therapy in Metastatic Prostate Cancer: A Retrospective Study on Intermittent ARPI Treatment

ESMO 2025: Impact of Dose Reductions on the Efficacy of Erdafitinib in Patients with Advanced or Metastatic Urothelial Carcinoma (mUC): A Post-hoc Analysis of the Phase 3 THOR Study Cohort-1 Evaluating Erda versus Chemotherapy (Chemo)

ESMO 2025: [68Ga]Ga-DPI-4452 PET/CT for Staging of Patients with Clear Cell Renal Cell Carcinoma

ESMO 2025: Efficacy and Safety Results from Formula-01: A Phase II Study of Disitamab Vedotin plus BCG in HER2 High Expression High-risk Non-muscle Invasive Bladder Cancer Patients

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

Does the urinary microbiome reflect the bladder-cancer-associated microbiome? Characterizing the microbiome in urine and cancer tissue in bladder cancer.

"It's Killed My Sex Life": Veteran Bladder Cancer Survivors' Perspectives on Sexual Problems and Intimacy.

The role of psoas muscle index in predicting outcomes after radical cystectomy.

Tumor Morphology as a Risk Factor for Muscle Invasiveness in Newly Diagnosed Bladder Cancer: A Stratified Analysis.

ctDNA-Guided Immunotherapy following Radical Cystectomy for Muscle-Invasive Bladder Cancer: Results from the TOMBOLA Trial.

Hyperthermic intravesical chemotherapy with gemcitabine versus Bacillus Calmette-Guerin in intermediate- and high-risk non-muscle-invasive bladder cancer.

Preferred Treatment Sequencing for Metastatic Urothelial Carcinoma (mUC) in the Era of Perioperative and First-Line (1L) Checkpoint Inhibitor: Results From a National Survey of Genitourinary Oncologists.

PTEN Deletions Are Associated With Tumor Progression But Unrelated to Patient Prognosis in Muscle-Invasive Urothelial Bladder Carcinomas: A Large Multi-Center Validation Study on 2710 Urothelial Bladder Carcinomas.

Decision tree models combining Bi-parametric vesical imaging reporting and data system and apparent diffusion coefficient metrics for predicting muscle-invasive bladder cancer.

Event-free survival and complete response rate as surrogate endpoints for overall survival in high-risk non-muscle-invasive bladder cancer: A meta-analysis of bacillus Calmette-Guérin-naive or -remote cases.

Oncological Outcomes of Trimodal Therapy in Primary Versus Secondary Muscle-invasive Bladder Cancer: A Multicenter Retrospective Study.

The Future of Non-muscle-invasive Bladder Cancer: Towards a Molecular-Digital Paradigm for Personalized Management.

Killing cancer takes guts: lessons learned from the manipulation of gut microbiome and immunotherapy for the future of urothelial carcinoma.

Development and Utilization of a Novel Electronic Health Record-Based Care Pathway for Nonmuscle-Invasive Bladder Cancer

Interdisciplinary Swiss consensus recommendations for follow-up after radical cystectomy and trimodal treatment for muscle-invasive bladder cancer.

The Changing Landscape of Urinary Diversion Post Cystectomy: A 15-Year Analysis of the NSQIP Database - Beyond the Abstract

Outcomes of Immune Checkpoint Inhibitor Rechallenge in Advanced Urothelial Carcinoma: Results from a Global Real-World Evidence Study - Beyond the Abstract

Penile & Urethral Cancers

Main Genomic Findings in Penile Cancer: An Update.

Efficacy and Safety of Immune Checkpoint Blockade in Locally Advanced or Metastatic Penile Cancer: A Systematic Review and Meta-Analysis.

Renal Cancer

Prediction of renal cell carcinoma: Development and validation of machine learning model.

Renal cell carcinoma masquerading as acute exacerbation of right-sided heart failure: a case report.

TFE-Altered Renal Cell Carcinoma: A Contemporary Review With Practical Insights and Diagnostic Pearls for Surgical Pathologists.

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC.

Robot-assisted Partial Nephrectomy with and without Mixed Reality - REALITATEM study.

Time-Dependent Comparative Effectiveness of First-Line Treatment for Metastatic Clear Cell Renal Cell Carcinoma: A Restricted Mean Survival Time-Based Network Meta-analysis.

International Radiosurgery Oncology Consortium of the Kidney (IROCK) Contouring Guidelines for Renal Cell Carcinoma treated with Stereotactic Ablative Radiotherapy.

Identification of Predictive Genomic Biomarkers in Metastatic Clear Cell Renal Cell Carcinoma: A Comprehensive Analysis of Real-World Clinicogenomic Data.

Contrasting features of papillary and chromophobe renal cell carcinoma revealed by whole genome sequencing.

A 24-Year Analysis of Percutaneous Renal Biopsy Trends in Australia.

Real-World Evidence of Nivolumab Monotherapy in Advanced Renal Cell Carcinoma from a Multicenter Retrospective Cohort Study by the Spanish Genitourinary Oncology Group - Beyond the Abstract

Ipilimumab and Nivolumab in Renal Cell Carcinoma: Real-World Experience in Rare Variant Renal Cell Carcinoma, Brain Metastases and Impact of Immune-Related Adverse Events and Steroid Use - Beyond the Abstract

Peritoneal Recurrence Following Nephrectomy for Localized Renal Cancer: A Multicenter European Real-World Analysis of Incidence, Pattern and Treatment (PEMET Study-UroCCR 124) - Beyond the Abstract

Prostate Cancer

The importance of targeted plus perilesional prostate biopsy in prostate cancer management (diagnosis and treatment)-real world evidence of a tertiary centre.

A Cost-Analysis and Micro-Costing Study of the Man Van Project: Comparing Prostate-Specific Antigen Testing Via a Nurse-Led Mobile Service with Primary Care.

Time-Resolved Förster Resonance Energy Transfer Nanoassay Based on CdTe Quantum Dots for Sensitive Detection of Prostate Cancer Antigen 3.

Pelvic Lymph Node Staging With PSMA PET in Prostate Cancer: Surgical Validation With Implications for Radiotherapy Planning.

Treatment Response and Outcomes of Prostate Cancer Patients Carrying the Germline MMS22L F722fs Mutation.

Syncromune®, Inc. Presents Phase 1 Data Highlighting Resolution of Bone Metastases in Metastatic Prostate Cancer Patients at Society of Urological Oncology 26th Annual Meeting

Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Physician Preferences Regarding Integration of Life Expectancy in Prostate Cancer Management.

Focal Cryotherapy in Prostate Cancer. Does Gleason Impact Results?

Prompt PSA changes as a prognostic marker for response to PSMA-radioligand therapy.

New techniques of prostate irradiation.

Therapy-Associated Neuroendocrine Prostate Cancer (tNEPC): A Diagnostic and Therapeutic Challenge in Uro-Oncology with Emerging Clinical Implications.

Effect of Marital Status on Years of Life Lost From Metastatic Prostate Cancer According to Race/Ethnicity.

Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination.

The 'Comparison of diagnostic accuracy of Luminal Index and standard of care MRI for Accelerated deTEction of prostate cancer' (CLIMATE) trial protocol.

Risk of bone fractures in patients with prostate cancer treated with maximal androgen blockade therapy: a systematic literature review and meta-analysis.

Real-World Burden and Management of Late Genitourinary Toxicity After Prostate Radiotherapy: Insights from IRRADIaTE, the Italian Registry of Radiotherapy-Associated Disorders and Urological Treatment & Evaluation.

Triplet therapy versus androgen receptor pathway inhibitor-doublet therapy in metastatic castration-sensitive prostate cancer: a real-world multicenter retrospective comparison.

Lack of survival benefit of pelvic lymph node dissection for patients with radical prostatectomy and postprostatectomy radiotherapy.

Assessing the Detection Power of Genome-Wide Copy Number Variation Profiles in Prostate Cancer Using Simulated Shallow Whole-Genome Sequencing Data.

Comparison of Cancer Detection Between Transrectal and Transperineal Prostate Biopsy in an Active Surveillance Cohort.

Local prostate cancer recurrence after radiotherapy or brachytherapy. What now? Retrospective analysis of salvage prostatectomy and salvage cryoablation.

Radical prostatectomy without prior biopsy in patients with positive PSMA PET and/or mpMRI: A practiced but poorly documented approach. Retrospective multicenter cohort study.

Optimizing management of metastatic castration-sensitive prostate cancer: From therapeutic advances to personalized care.

Diagnostic accuracy and outcomes of lymph node staging in intermediate-risk prostate cancer.

Are Urologists and/or Radiation Oncologists Biased when Reporting of Advantages and Disadvantages of Surgery versus Radiation in Consultations for Early-Stage Prostate Cancer?

Results from a prospective registry of 18F-Fluciclovine PET/CT use in prostate cancer management: a cautionary lesson for implementation of PSMA PET.

Spatial-Spectral Deep Learning for Prostate Cancer Tissue Classification in Infrared Spectroscopy.

Comorbidity Level and Risk of 90-day and 18-month Complications Among Patients Undergoing Radical Prostatectomy for Prostate Cancer in the Military Health System.

Health-related Quality of Life Outcomes of Salvage Metastasis-directed Treatment Versus Elective Nodal Treatment for Oligorecurrent Nodal Prostate Cancer: A Secondary Analysis of the Phase 2, Open-label PEACE V-STORM Randomized Trial.

Automated Classification of Adverse Events After Hydrogel Perirectal Spacer Insertion for Prostate Cancer Using Large Language Models.

Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective "ProFam-Risk" Study.

Beyond Menopause: Ending the Inequality-Why Men with Prostate Cancer Still Lack Therapies for Hot Flushes - Beyond the Abstract

Association Between the PRIMARY Score at Staging Prostate-specific Membrane Antigen Positron Emission Tomography and Overall Survival Among Patients with Newly Diagnosed Prostate Cancer - Beyond the Abstract

Upper Tract Tumors

Tumor cell invasion of blood vessels predicts poor survival in upper tract urothelial carcinoma following radical nephroureterectomy.

Association of PD-L1 and PD-1 Expression With Clinicopathological Characteristics and Prognosis in Upper Tract Urothelial Carcinoma.

Risk of Recurrence and Progression After Endoscopic Kidney-sparing Surgery for Upper Tract Urothelial Carcinoma.

Training and external validation of machine learning supervised prognostic models of upper tract urothelial cancer (UTUC) after nephroureterectomy.

Real-world efficacy and safety of disitamab vedotin monotherapy or in combination with PD-1 inhibitors in locally advanced or metastatic upper tract urothelial carcinoma: a multicenter retrospective study.

A Split Renal Function-Based Approach for Predicting New Baseline Glomerular Filtration Rate After Radical Nephroureterectomy

Testicular Cancer

New insights into Nectin-4 expression in testicular choriocarcinoma and its potential treatment with Enfortumab Vedotin: analysis of a multi-institutional series and association with clinical-pathological features.

Recent Advances in Understanding the Biological Role of microRNA-371a-3p in Testicular Germ Cell Tumors.

Accuracy, readability, and understandability of EAU guidelines bot for testicular cancer.

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