UroAlert - GU Oncology Weekly

January 15, 2026

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

Saudi FDA Grants Accelerated Approval to ImmunityBio’s ANKTIVA® for Non-Muscle Invasive Bladder Cancer with Carcinoma In-Situ

Alopecia following single-dose postoperative intravesical gemcitabine in nonmuscle-invasive bladder cancer: A multi-institutional case series.

Surgical outcomes after neoadjuvant avelumab with or without chemotherapy for Muscle-Invasive bladder cancer: a Post-Hoc analysis of the aura trial (Oncodistinct-004).

Repeat transurethral resection and contemporary oncologic outcomes among patients with non-muscle invasive urothelial carcinoma of the bladder.

Second-look transurethral resection in high-grade Ta non-muscle invasive bladder cancer.

Ferring Pharmaceuticals and Theralase® Technologies Announce Clinical Development Agreement to Investigate Combination Therapy in Bladder Cancer

Alcohol Use Disorder versus Adverse In-Hospital Outcomes after Radical Cystectomy and Ileal Conduit Urinary Diversion.

Blue Light Cystoscopy with Hexvix Significantly Improves the Detection of Bladder Cancer Using Modern HD Equipment

Inflammation Indices as Predictive Markers of Muscle-Invasive Bladder Cancer.

Sarcomatoid urothelial carcinoma: advances and challenges.

An Atypical Presentation of Muscle-Invasive Papillary Urothelial Carcinoma Mimicking Extensive Urethral and Bladder Calculi: A Case Report.

Updates in bladder and prostate pathology: Diagnostic consensus and clinical relevance.

Efficacy and safety of active surveillance and chemoablation in the management of non-muscle invasive bladder cancer (NMIBC): Systematic review and pooled analysis by the European Association of Urology-Young Academic Urologists: Urothelial Carcinoma Work

Nectin-4 PET for predicting enfortumab vedotin dose-response in urothelial carcinoma.

The Impact of Intravesical Instillations on Quality of Life in Patients with Non-Muscle-Invasive Bladder Cancer: A Systematic Review - Beyond the Abstract

Reduced-Dose Enfortumab Vedotin, Treatment Continuity, and Survival in Urothelial Cancer - Beyond the Abstract

Penile & Urethral Cancers

Systemic Chemotherapy in Penile Squamous Cell Carcinoma: Mechanisms, Clinical Applications, and Evidence-Based Regimens.

Subsequent-line Systemic Therapy for Metastatic or Recurrent Penile Cancer: A Systematic Review of Efficacy, Toxicity, and Outcomes.

Video-endoscopic versus open inguinal lymphadenectomy: Long-term oncological outcomes in penile cancer.

Penile Cancer and Lymph Node Management: A Call for Standardization - Beyond the Abstract

Renal Cancer

The Effects of Bone-Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX).

Radiomics and Image-based Artificial Intelligence for Predicting Recurrence and Survival After Surgery in Localized Renal Cell Carcinoma: An APPRAISE-AI Systematic Review and Meta-analysis.

Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2.

Hereditary renal cell carcinoma surveillance protocols: a review of the literature and proposed recommendations.

Prognostic impact of nephrectomy and a prediction model for estimating the survival benefit of nephrectomy for patients with clear cell renal cell carcinoma (ccRCC).

Indeterminate Surgical Margins (Rx) in Renal Cell Carcinoma Surgery: Rates, Predictive Factors, and Impact on Overall Survival.

The Role of Selenium as an Antioxidant in the Treatment of Renal Cell Carcinoma.

Immunotherapy combinations in favourable risk score metastatic renal cell carcinoma, an individual patients data metanalysis.

Durable Responses to Immune Checkpoint Inhibitor-Based Regimens for Metastatic Clear Cell Renal Cell Carcinoma Stratified by IMDC Risk Groups: A Pooled Analysis of Four Randomized Phase 3 Trials - Beyond the Abstract

Nivolumab in Metastatic Clear-cell Renal Cell Carcinoma: An Integrative Biomarker Analysis from the NIVOREN GETUG-AFU 26 Phase 2 Study - Beyond the Abstract

Prostate Cancer

Archeus Technologies Doses First Patient with ART-101 in Phase 1 Prostate Cancer Study

Inhibition of Growth and Induction of Apoptosis of Human Prostate Cancer Cells by Enzymatic Blockage of Kallikreins.

Correlation of Tumor Absorbed Dose with Progression-Free Survival in Metastatic Castration-Resistant Prostate Cancer Treated with 177Lu-PSMA.

2-year outcomes of the SPARC phase II trial: Simultaneous focal boost with stereotactic radiotherapy for localised intermediate to high-risk prostate cancer.

Association Between Sociodemographic Marginalization and Combination Therapy for Metastatic Hormone-Sensitive Prostate Cancer: Population-Based Cohort Study in Ontario, Canada.

MECOM Function is Critical for AR-Driven Treatment-Resistant Prostate Cancer.

Pathology outcomes of PI-RADS category 4 lesions in the peripheral zone: impact of MRI signal features and lesion size.

Predicting Long-Term Risk for Prostate Cancer Mortality Following a Prostate-Specific Antigen Screening Test: Prognostic Model Development and External Validation.

A REtrospective Study to Describe the Real-World Treatment Landscape in Patients with Metastatic Castration-Resistant PROstate Cancer: REMPRO.

Postoperative Treatment and Survival in Locally Advanced Prostate Cancer: Real-World Outcomes.

Location matters: Reduced detection of csPCa in transition zone versus peripheral zone PI-RADS lesions.

Long-term trends in androgen-directed therapy in advanced prostate cancer: a 29-year national analysis.

Avoiding unnecessary biopsy in suspicious prostate cancer using PRIMARY score ≤3 and PSAD ≤0.2 ng/mL/cm3: a real-world, dual-center study from China.

AdvanCell Initiates Phase 2 Expansion Trial of ADVC001, a Novel Targeted Alpha Therapy for Prostate Cancer

Focal irreversible electroporation for the treatment of localised prostate cancer: a systematic review.

Retrospective Analysis of Vesicourethral-Anastomosis Stricture/Urethral Stricture After Robotic-Assisted Laparoscopic Radical Prostatectomy With and Without Radiotherapy.

Living with a Prostate Cancer Patient: Real-world Evidence from the Europa Uomo Prostate Cancer Partners in Europe Research Study.

The Role of Nutrition in Prostate Cancer Risk, Progression, and Mortality: A Comprehensive Review.

Optimizing PSMA-617-based inhibitors through charged linker modifications: Insights into structure-activity relationships.

Evaluating the Impact of Centralizing Artificial Urinary Sphincter Implantation Services in France: A National Population-Based Model on Travel Times, Equity, and Patient Outcomes.

Strong-Gradient Diffusion-Weighted Imaging of Prostate Cancer Using an Inside-Out Nonlinear Gradient Coil.

Does addition of multiparametric MRI to PSMA PET/CT improve diagnostic accuracy for biochemical recurrence after radical prostatectomy?

Significance and Implications of Prostate Cancer: Critical Overview for Future Directions in Africa.

Co-PSMA Abstract Accepted for Oral Presentation at EAU Annual Congress 2026

Effectiveness and Safety of Lenvatinib and Everolimus after Immune Checkpoint Inhibitors in Metastatic Renal Cell Cancer: A Systematic Review.

Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma.

Feasibility of reusing online-generated treatment plans for adaptive radiotherapy in prostate cancer.

Enzalutamide in metastatic hormone-sensitive prostate cancer: results from the international, multicentre, real-world ARON-3 study.

Validation of the Prostatype® P-score for predicting prostate cancer specific mortality in a multiethnic U.S. veterans cohort.

Generative Artificial Intelligence Successfully Automates Data Extraction From Unstructured Magnetic Resonance Imaging Reports: Feasibility in Prostate Cancer Care.

Long-term oncological outcomes of pelvic lymph node dissection during radical prostatectomy.

European Registry of Next Generation Imaging in Advanced Prostate Cancer (RING): Protocol for an International, Prospective Registry Study - Beyond the Abstract

68Ga-PSMA-11 in Staging of Unfavorable Intermediate- and High-Risk Prostate Cancer Reduces Indication for Noncurative Prostatectomy: A Prospective, Multicenter, International IAEA Study - Beyond the Abstract

Chromatin Remodeling Restrains Oncogenic Functions in Prostate Cancer - Beyond the Abstract

NKX2-1 Drives Neuroendocrine Transdifferentiation of Prostate Cancer via Epigenetic and 3D Chromatin Remodeling - Beyond the Abstract

Optimizing [212Pb]Pb-AB001 Radiopharmaceutical Therapy Schedules in PSMA-Positive Subcutaneous Prostate Cancer Xenografts - Beyond the Abstract

Increasing Phytochemical-Rich Foods and Lactobacillus Probiotics in Men with Low-Risk Prostate Cancer-a Randomised, Double-Blind, Placebo-Controlled Trial - Beyond the Abstract

The Pelvic Rosetta Classification Project: An Interdisciplinary Proposal for a Lymph Node Map of the Pelvis in Prostate Cancer - Beyond the Abstract

Upper Tract Tumors

Artificial intelligence-based personalized oncological outcome prediction model for upper urinary tract urothelial carcinoma after radical nephroureterectomy: A development and multicenter validation.

Chemotherapy sequential disitamab vedotin in combination with tislelizumab as systemic therapy of upper tract urothelial carcinoma with cutaneous metastasis: A case report and literature review.

Clinical validation of UroCAD test for upper tract urothelial carcinoma detection: results from a prospective multi-center study.

Performance of fluorescence in situ hybridization in detecting lower versus upper tract urothelial carcinoma.

Testicular Cancer

Difficult Conversation Case: Missed Testicular Cancer.

Testicular cancer in intersex individuals: A systematic review for clinical practice.

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