UroAlert - GU Oncology Weekly

December 25, 2025

Videos

Peer-to-Peer Clinical Conversations

Results from the Phase 3 PSMAfore Trial in Metastatic Castration-Resistant Prostate Cancer - Karim Fizazi

Karim Fizazi

Neeraj Agarwal speaks with Karim Fizazi about the PSMAfore trial, a phase three study examining Lutetium-177 PSMA-617 in metastatic castration-resistant prostate cancer patients who had exhausted one second-generation androgen receptor pathway inhibitor.

Phase 3 Trial Results for Intravesical Cretostimogene Grenadenorepvec in Bladder Cancer - Mark Tyson

Mark Tyson

Mark Tyson shares comprehensive cretostimogene grenadenorepvec data with Sam Chang, explaining this oncolytic immunotherapy's dual mechanism targeting RB pathway-deficient tumor cells through viral replication and GMCSF-mediated immune augmentation.

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

Incarcerated Patients Present with More Advanced Bladder Cancer Stage: A Statewide Analysis.

Compliance with Intravesical BCG Therapy for Non-Muscle Invasive Bladder Cancer.

Neoadjuvant Chemotherapy Prior to Trimodality Therapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis.

Hyperglycemia and bladder cancer prognosis in a Finnish population-based cohort.

Long non-coding RNAs define favourable biology in high-risk non-muscle-invasive bladder cancer.

Bacillus Calmette-Guérin-exposed Non-muscle-invasive Bladder Cancer: Survival Benchmarks, Bladder-sparing Strategies, and Implications for Trial Design.

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends.

Predictive Value of Prior Non-muscle-invasive Bladder Cancer for the Effectiveness of Neoadjuvant Chemotherapy in Localized Muscle-invasive Bladder Cancer: A Real-world Analysis of the BLADRAC Cohort.

Prognostic Factors of Trimodal Therapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis.

Intraoperative Skills for Transurethral Resection of Bladder Tumor: Objective Assessment and Construct Validity of the ENTRY Metrics.

Guidance for Avoiding Patient Pain and Discomfort During Transurethral Cystoscopy - Beyond the Abstract

Clinical Evaluation of a Novel Deintensified Surveillance Protocol for Low-risk Non-muscle-invasive Bladder Cancer: A Prospective Study in 250 Patients.

Exploring the influence of the bladder microbiome on BCG immunotherapy outcomes for high-risk non muscle invasive bladder cancer.

The changing landscape of urinary diversion post cystectomy: A 15-year analysis of the NSQIP database.

Contemporary outcomes and disease burden of high-grade T1 bladder cancer.

Penile & Urethral Cancers

Comparison of efficacy and prognosis between neoadjuvant chemotherapy and adjuvant chemotherapy in penile cancer patients with regional lymph node metastasis.

Suprapubic antegrade endoscopic inguinal lymphadenectomy with great saphenous vein preservation for penile cancer: a stepwise technique (with video).

Prevalence and time trends of human papillomavirus in penile cancer over 26 years-A comprehensive study of 1040 penile cancer cases from Denmark.

Renal Cancer

The Role of Homologous Recombination Deficiency (HRD) in Renal Cell Carcinoma (RCC): Biology, Biomarkers, and Therapeutic Opportunities.

Does Cardiopulmonary Bypass Affect Outcomes in Nephrectomy with Level III/IV Caval Thrombectomy for Renal Cell Carcinoma?

Urine C-reactive protein content and non-invasive molecular grading of renal cell carcinoma.

Successful Combination Therapy With Lenvatinib Plus Pembrolizumab for Rare Case of Advanced Renal Cell Carcinoma With Ocular Adnexal Metastasis.

Comorbidity and Risk of Complications and Readmissions Following Surgery for Patients With Renal Cell Carcinoma in the Military Health System.

Kidney-sparing Treatments for Local Recurrence in Renal Cell Tumours After Partial Nephrectomy or Focal Therapy: A Systematic Review.

Development and Validation of an Intratumor Heterogeneity-Based Prognostic Model for Clear Cell Renal Cell Carcinoma.

Advancements of investigational agents for renal cell carcinoma: what clinical progress have we seen in the last 5 years?

Clinical and Molecular Characterization of KRAS-Mutated Renal Cell Carcinoma.

Real-world efficacy and safety of pembrolizumab plus lenvatinib in patients with metastatic renal cell carcinoma: a multi-institutional retrospective study.

[99mTc]Tc-Sestamibi SPECT/CT for the Diagnosis of Kidney Tumours: A Multi-Centre Feasibility Study (MULTI-MIBI Study) - Beyond the Abstract

Prostate Cancer

Evaluating Differential Metabolic Profiles by Prostate Cancer Risk Among Prostate Cancer Patients.

Canadian Prostate Cancer Trends in the Context of PSA Screening Guideline Changes.

Integration of Darolutamide in the Treatment Landscape for Metastatic Hormone-sensitive Prostate Cancer: A Systematic Review and Network Meta-analysis of Efficacy and Safety.

Pre-PROTO-PRIME: stereotactic body proton therapy to the prostate and pelvic nodes for high-risk and node-positive prostate cancer - feasibility, acute toxicity and dosimetric insights.

Developing therapeutic strategies to target MCL1 and BCLXL in lethal prostate cancer.

Western Dietary Pattern, Prudent Dietary Pattern, and Cancer-Specific Quality of Life in Prostate Cancer Survivors in the Health Professionals Follow-up Study.

Initial pain score during viscous lidocaine instillation and clinical characteristics as predictors of overall pain in fusion prostate biopsy.

CDC7 is a targetable regulator of advanced prostate cancer.

Primary Noncontrast Magnetic Resonance Imaging for Prostate Cancer Screening: A Randomized Clinical Trial (PROSA).

Genomic variation in symptom expression in castrate-resistant prostate cancer.

Whole-Blood RNA Expression of Immunosuppressive Cell-Related Genes Is Associated With Prostate Cancer Progression.

High-dose vitamin D supplementation and prostate cancer progression: a phase II randomised trial in localised prostate cancer cases with intermediate risk of progression (ProsD).

Integrating NLP to Enhance Algorithmic Identification of Metastatic and Castration-Resistant Prostate Cancer in Large Claims-Based Studies.

Digital Systematic Collection of Data for Patient-reported Outcome and Experience Measures Reveals Real-world Recovery Trajectories After Robot-assisted Radical Prostatectomy.

Performance of the Prostate Health Index Test in Men with PSA Levels between 10 and 20 ng/mL.

Personalizing prostate cancer education for patients using an EHR-Integrated LLM agent.

[18F]-Fluciclovine or [68Ga]-PSMA-11 Molecular Imaging To Guide Dose Escalation of Salvage Radiotherapy After Radical Prostatectomy for Prostate Cancer: The EMPIRE-2 Trial.

Docetaxel with Androgen Deprivation and Radiotherapy in High-risk Localized Prostate Cancer: An ICECaP Individual Patient Data Meta-analysis.

Sociodemographic Factors Associated with Tissue-Based Genomic Testing for Prostate Cancer.

PURE-MRI: An international study assessing physician accuracy in delineating the prostate and urethra on prostate MRI.

Individualized Precision Prostate Biopsy Strategy for Patients With PI-RADS Score 2: A Retrospective Multicenter Study.

Efficacy and toxicity of low-doses versus standard-dose enzalutamide in advanced prostate cancer. a real-world study with implications for cancer prevention/interception.

Expert opinion on the management of anemia in prostate cancer patients receiving PARP inhibitors.

A roadmap for future clinical research in advanced prostate cancer: Findings from the Advanced Prostate Cancer Consensus Conference (APCCC) 2024.

Utilization of Pre-Diagnostic Prostate MRI Among Rural Americans: An Analysis of Medicare Claims for Elevated PSA.

Emerging Evidence for Sequencing and Combining PSMA-Based Therapies in Prostate Cancer - Beyond the Abstract

ESUR: Opportunities for PSMA-PET/CT and Whole-Body MRI in Advanced Prostate Cancer - Beyond the Abstract

Oncologic Outcomes of Template versus Radioguided Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography Scan - Beyond the Abstract

4K Density: Adjusting the 4Kscore for Prostate Volume to Improve Risk Stratification of Clinically Significant Prostate Cancer in Men Undergoing Prostate Biopsy - Beyond the Abstract

Upper Tract Tumors

Elevated creatinine-to-hemoglobin ratio is a novel preoperative marker for worsened survival outcomes in upper tract urothelial carcinoma: analysis from the ROBUUST registry.

Diagnostic Accuracy of the Oncuria-Detect Multiplex Immunoassay in Detecting Upper Tract Urothelial Carcinoma.

Development of a reoperative risk prediction model of muscle-invasive upper tract urothelial carcinoma using clinical and radiomic computed tomography features: Initial results from a multi-institutional Canadian study.

Testicular Cancer

High-dose chemotherapy in male germ cell cancer patients-a study by the SWENOTECA group.

Thoracic residual germ cell tumor resection after high-dose chemotherapy with autologous stem cell transplantation in relapsed patients.

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