UroAlert - GU Oncology Weekly

November 19, 2025

Videos

Peer-to-Peer Clinical Conversations

Addressing Urology Disparities Through Community Partnerships and Institutional Collaboration - Samuel Washington

Samuel Washington

Zachary Klaassen hosts Samuel Washington to discuss social determinants of health and healthcare disparities in urologic oncology.

Shifting From TURBT to Chemoablation in Low-Grade Intermediate-Risk NMIBC - Max Kates

Max Kates

Zachary Klaassen hosts Max Kates to discuss the role of intravesical mitomycin chemoablation for patients with low-grade intermediate-risk non–muscle invasive bladder cancer.

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

New Budget Impact Model Study in 4 European Countries Concludes That BLC Use Offers a Clinically Meaningful and Economically Rational Approach to NMIBC Management

Hexaminolevulinate-enhanced photodynamic diagnosis in the management of non-muscle-invasive bladder cancer (NMIBC): the influence of differing European health care payment systems on the potential financial impact of adoption.

Clinical and Molecular Predictors of Response and Survival in Patients with Urothelial Carcinoma Treated with Enfortumab Vedotin: A Systematic Review and Meta-analysis.

Prognostic Role of Different T1 Substaging Systems on Recurrence and Progression in Non-muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis.

The worldwide adoption of enhanced endoscopic imaging in diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC): snapshot analysis from a global survey.

The role of gemcitabine-docetaxel in the management of NMIBC: a scoping review of current status and future directions.

The role of immune checkpoint inhibitors in the management of NMIBC: a scoping review of current status and future direction.

Early Detection of Metastatic Progression by Circulating Tumor DNA in Patients Undergoing Bladder-preserving Trimodality Therapy.

New Survey Reveals Non-Muscle Invasive Bladder Cancer Patients Seek More Care Conversations

The Impact of Intravesical Instillations on Quality of Life in Patients with Non-Muscle-Invasive Bladder Cancer: A Systematic Review.

Gender-based Differences in Psychosocial Well-being Among Bladder Cancer Survivors.

Epidemiology, treatment patterns and effectiveness of adherence to Bacillus Calmette-Guérin therapy in intermediate and high-risk non-muscle-invasive bladder cancer patients: a retrospective cohort analysis using German health claims data.

Defining NECTIN4 Amplification and Protein Expression in Urothelial Carcinoma and Histologic Subtypes.

Penile & Urethral Cancers

Personalized systemic therapy of penile cancer: molecular targets and new therapeutic horizons.

Tissue Factor Expression in Penile Squamous Cell Carcinoma: A Potential Marker of HPV-Independent Disease.

Renal Cancer

Computed tomography guided microwave ablation for the treatment of clinical T1a renal cell carcinoma: a comparison to robot-assisted laparoscopic partial nephrectomy.

The effect of neighborhood deprivation on access to surgical care for pediatric renal tumors.

TFE3-rearranged and TFEB-altered renal cell carcinoma: from classification to real-life. Insights from a national Italian survey.

Utilization of radical nephrectomy for patients with clinical stage T1 renal masses: Evaluation of opportunities for quality improvement.

Advances in Diagnosis, Prognosis, and Treatment of Renal Cell Carcinoma.

Nivolumab in Metastatic Clear-cell Renal Cell Carcinoma: An Integrative Biomarker Analysis from the NIVOREN GETUG-AFU 26 Phase 2 Study.

Role of Radiotherapy in the Management of Primary Renal Cell Carcinoma: Recommendations from the Société Française De Radiothérapie Oncologique (SFRO, the French Society for Radiation Oncology) - Beyond the Abstract

Pre-treatment C-reactive protein level is a prognostic marker of patients treated with immune checkpoint inhibitors for renal cell carcinoma: a systematic review and meta-analysis.

Propensity Score-Matched Analysis of Neoadjuvant vs. Adjuvant Therapy in Renal Cell Carcinoma.

Real-World Experience With Lenvatinib Plus Everolimus (LEN+EVE) in Patients With Pretreated Advanced Renal Cell Carcinoma (RELEVANCE): A Retrospective, Multicenter Case Series.

Toxicity-related immunotherapy discontinuation and outcome in patients with advanced renal cell carcinoma treated with immune-based combinations (ARON-1 study).

Prostate Cancer

Micro-ultrasound Proven Non-Inferior to MRI for Prostate Cancer Diagnosis in OPTIMUM Randomized Trial

[225Ac]Ac-PSMA I&T: A Preclinical Investigation on the Fate of Decay Nuclides and Their Influence on Dosimetry of Salivary Glands and Kidneys.

Johnson & Johnson Set to Revolutionize the Treatment of Cancer with the Acquisition of Halda Therapeutics

Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery.

Localized high-risk prostate cancer harbors an androgen receptor activity-low subpopulation susceptible to HER2 inhibition.

Metastatic prostate cancer: Clinical trials to watch.

Enhanced recovery after surgery protocol does not reduce the length of postoperative hospitalization after robot-assisted radical prostatectomy. Outcomes from the first randomized controlled trial: the (PROSTA-RAAC) study.

Therapeutic outcomes of ²²⁵Ac/¹⁷⁷Lu-PSMA combination therapy in advanced metastatic Castration-Resistant prostate cancer: A systematic review and Meta-Analysis.

Post-prostatectomy prostate cancer treated with radiation therapy: adverse features and ADT use in a statewide consortium.

Best therapeutic approach in metastatic hormone-sensitive prostate cancer based on disease volume: a systematic review and network meta-analysis.

Training and validation of a novel 14-gene expression signature associated with prostate cancer metastasis and postoperative recurrence.

Long-Term Follow-Up of Neoadjuvant Enzalutamide Plus Androgen Deprivation Therapy in Localized Prostate Cancer: A Secondary Analysis of a Neoadjuvant Feasibility Trial.

The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management.

Combined DNA-PK and PARP Inhibition as a Therapeutic Strategy in BRCA-Mutated Prostate Cancer: An in Vitro Pilot Study.

68Ga-PSMA-11 in Staging of Unfavorable Intermediate- and High-Risk Prostate Cancer Reduces Indication for Noncurative Prostatectomy: A Prospective, Multicenter, International IAEA Study.

Abiraterone-Associated Renal Damage in Patients with Advanced Prostate Cancer as a Risk Factor for Mortality and Chronic Kidney Disease.

AI-Driven Body Composition Monitoring and Its Prognostic Role in mCRPC Undergoing Lutetium-177 PSMA Radioligand Therapy: Insights from a Retrospective Single-Center Analysis - Beyond the Abstract

New Prostate Cancer Guideline: Is Biopsy of PI-RADS 3 Lesions Meaningful? The Role of Multiparametric MRI-Ultrasound Fusion Biopsy in Detecting Clinically Significant Prostate Cancer.

A mixed-methods evaluation of a peer-led, co-produced, asset-based intervention for early diagnosis of prostate cancer for Black men: the PROCAN-B study.

Design of debunking the frailty-sarcopenia-ADT axis in metastatic prostate cancer with multicomponent exercise: the FIERCE trial protocol.

Clinical Grade Interpretable Artificial Intelligence Tool for Automated Detection of Lymph Node Metastasis in Prostate Cancer.

Predicting PSA50 response to [Formula: see text]Lu-PSMA therapy using machine learning and automated total tumor volume.

Re-Irradiation in Patients Affected by Prostate Cancer and Relapsing After Previous Definitive or Postoperative Radiotherapy - Beyond the Abstract

MRI-Fusion Biopsy Era: The Role of Perineural Invasion in Low-Risk Prostate Cancer - Beyond the Abstract

High-Dose-Rate Brachytherapy for Salvage Treatment of Prostate Cancer Recurrence Post-Prostatectomy and Radiotherapy: A Multicenter Retrospective Analysis (HDR-REPOPRA) by UroGEC - Beyond the Abstract

Quantification of Prostate Cancer Gleason Pattern 4 to Predict Oncological Outcome - Beyond the Abstract

The Role of Liquid Biopsy in the Management of Patients with Genitourinary Malignancies.

ONECUT2: A Validated Drug Target and Lineage Plasticity Driver in Prostate Cancer and Other Malignancies.

Treatment Preferences among Patients with Hormone-Sensitive Prostate Cancer in France, Spain, China, South Korea, and Japan: A Discrete-Choice Experiment.

Value of Additional Systematic Cores During Magnetic Resonance Imaging-guided Targeted Biopsy in Prostate Cancer Screening for Young Men: Results from the PROBASE Trial.

PARP Inhibitors in Metastatic Castration-resistant Prostate Cancer: Rationale, Mechanisms, and Clinical Applications.

177Lu-Prostate-Specific Membrane Antigen Neoadjuvant to Stereotactic Ablative Radiotherapy for Oligorecurrent Prostate Cancer (LUNAR): An Open-Label, Randomized, Controlled, Phase II Study.

Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study.

Codon specific readthrough as a mechanism of BRCA2 restoration in acquired PARP inhibitor and chemotherapy resistance.

Caloric Restriction Enhances the Efficacy of Antiandrogen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation.

Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer.

Chromatin remodeling restrains oncogenic functions in prostate cancer.

Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth.

A PHF19-YTHDC1 condensate switches EZH2-mediated gene suppression to activation for prostate cancer progression.

Stockholm3 Versus Prostate-specific Antigen in Prostate Cancer Screening: 9-year Outcomes Demonstrating Improved Detection of Aggressive Cancers and Reduced Overdiagnosis from the STHLM3 Trial.

Therapeutic targeting of prostate-specific membrane antigen could limit its potential as benchmark imaging.

Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models.

PRDM16 Regulates Prostate Cancer Cell Dormancy and Prevents Bone Metastatic Outgrowth.

RCC2 and CD24 cooperate to modulate prostate cancer progression through vimentin ubiquitination and β-catenin activation.

Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.

Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels.

The Pelvic Rosetta Classification Project: An Interdisciplinary Proposal for a Lymph Node Map of the Pelvis in Prostate Cancer.

Rechallenge and Extended [177Lu]Lu-PSMA Therapy in Metastatic Prostate Cancer.

Evaluating Clinical Tools to Monitor Cardiovascular Risk in Men With Prostate Cancer Receiving Hormone Therapy.

Effect of prior HoLEP procedure on multiparametric MRI accuracy in detection of prostate cancer.

Rising metastatic prostate cancer rates but narrowing racial gap.

Plasma Epigenomic Profiling Reveals Treatment-Emergent Squamous Transformation in Prostate Cancer - Beyond the Abstract

Upper Tract Tumors

A Systematic Review of Intracavitary Therapies for Upper Tract Urothelial Carcinoma.

Efficacy of radiotherapy combined with systemic therapy for retroperitoneal lymph node metastasis in upper tract urothelial carcinoma(UTUC) patients after radical nephroureterectomy.

Testicular Cancer

The role of lipid metabolism and peroxisome proliferator activation in mediating pro-cancer phenotypes of poly- and perfluoroalkyl substances in testicular cancer.

Comparative efficacy and safety of robotic-assisted versus open retroperitoneal lymph node dissection in testicular cancer management: a systematic review and meta-analysis.

Improved quality of care for testicular germ cell cancer patients by the implementation of an interdisciplinary testis cancer clinic.

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