UroAlert - GU Oncology Weekly

September 18, 2025

Videos

Peer-to-Peer Clinical Conversations

Selecting Patients for Triplet Therapy in Metastatic Prostate Cancer - Oliver Sartor

Oliver Sartor

Zachary Klaassen speaks with Oliver Sartor about treatment intensification in metastatic hormone-sensitive prostate cancer, focusing on triplet therapy selection.

Nadofaragene Firadenovec for BCG-Unresponsive CIS: Efficacy, Durability, and Practical Considerations, A Case-based Discussion - Vikram Narayan

Vikram Narayan

Zachary Klaassen speaks with Vikram Narayan about nadofaragene firadenovec, a first-in-class gene therapy for BCG-unresponsive bladder cancer.

Beyond the Abstracts

Oncologic and Renal Function Outcomes of Segmental Ureterectomy vs. Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis - Beyond the Abstract

Radiogenomic Correlation of Hypoxia-Related Biomarkers in Clear Cell Renal Cell Carcinoma - Beyond the Abstract

Conference Coverage

ASCO GU 2025: Targeting Bladder Cancer with Antibody Drug Conjugates

ASCO GU 2025: Overcoming Challenges of Antibody Drug Conjugate Toxicity in Bladder Cancer

ASCO GU 2025: Nectin-4 Targeted ADC, SHR-A2102, in Patients With Advanced or Metastatic Urothelial Carcinoma: A Phase 1 Study

ASCO GU 2025: Avelumab First-Line Maintenance in Patients With Advanced Urothelial Carcinoma With or Without Diabetes Mellitus: Long-Term Outcomes From JAVELIN Bladder 100

ASCO GU 2025: Lenvatinib plus Tislelizumab as First-Line Therapy for Advanced Fumarate Hydratase-Deficient Renal Cell Carcinoma: A Single-Center, Single-Arm, Phase II Study

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

Cost-effectiveness of Perioperative Durvalumab Plus Platinum-based Chemotherapy in Muscle Invasive Bladder Cancer - Expert Commentary

Perioperative chemotherapy use and related outcomes in muscle-invasive bladder cancer in Australia.

Fibroblast Growth Factor Receptor 3 Alteration Status and Outcomes on Immune Checkpoint Inhibitors in Patients With Metastatic Urothelial Carcinoma.

Prolonged Progression-Free Survival, Disease-Free Survival and Cystectomy Avoidance with IL-15 Receptor Lymphocyte-Stimulating Agent NAI plus BCG in BCG-Unresponsive Papillary-Only NMIBC.

Is a second TUR necessary in patients with primary high-grade Ta NMIBC, particularly in the context of initial cases?

Oncological outcomes for patients with European Association of Urology definitions of BCG failure treated with radical cystectomy.

Vesica Health Receives AUA Guideline Inclusion

Clinicopathologic and Prognostic Features of Sarcomatoid Urothelial Carcinoma: A Retrospective Study of 136 Patients With Emphasis on Early-Stage (pT1) Disease.

End Points for the Next-Generation Bladder-Sparing Perioperative Trials for Patients With Muscle-Invasive Bladder Cancer.

Cisplatin-ineligible patients with muscle-invasive bladder cancer demonstrate poor long-term survival following immediate radical cystectomy.

Ferring Japan Announces PMDA Acceptance of NDA Filing for Nadofaragene Firadenovec

Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer.

Low-grade non-muscle-invasive bladder cancer: molecular landscape, treatment strategies and emerging therapies.

Penile & Urethral Cancers

Sexual and urological reconstruction following penectomy for penile cancer: phalloplasty.

Single-cell transcriptomic profiling reveals distinct tumor microenvironments in HPV-associated penile squamous cell carcinoma.

Characterization of CD8+ and FOXP3+ T-Cell Ratios in Tumor and Stromal Compartments of Penile Squamous Cell Carcinoma: An Analysis Across Histologic Subtypes and Grades.

Renal Cancer

Stage Migration in Surgically Treated Renal Cell Carcinoma in México: A 44-Year Analysis of Survival Outcomes and Stage-Specific Prognostic Factors.

Characterization of complex renal cysts in hereditary leiomyomatosis and renal cell cancerUsing magnetic resonance based qualitative features.

Machine learning model in multi-omics perspective demystifies the prognostic significance of crotonylation heterogeneity in clear cell renal cell carcinoma.

Role of radiotherapy in the management of primary renal cell carcinoma: Recommendations from the Société française de radiothérapie oncologique (SFRO, the French society for radiation oncology).

Case Report: Successful delivery following chemotherapy in a pregnant patient with metastatic SMARCB1-deficient renal medullary carcinoma.

Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling.

Camera Port Swapping in Transperitoneal Robotic Partial Nephrectomy: A Feasible Alternative to the Retroperitoneal Approach for Posterior Renal Tumors.

End-of-life and palliative care in patients with metastatic renal cancer.

Long-term oncologic outcomes of metastatic clear-cell renal cell carcinoma after local therapy alone.

Efficacy of Stereotactic Ablative Body Radiotherapy (SABR) in uncommon subtypes of primary kidney cancer: An analysis from the International Radiosurgery Oncology Consortium of the Kidney.

Is Preoperative Anticoagulation in Nephrectomy with Caval Thrombectomy Necessary? A Multicenter Retrospective Cohort Study.

Prostate Cancer

Transperineal MRI-US Fusion-Guided Biopsy with Systematic Sampling for Prostate Cancer: Diagnostic Accuracy and Clinical Implications Across PI-RADS.

Real-world data from a single-center cohort of patients with metastatic hormone-sensitive prostate cancer in Spain: analysis of response, progression, and quality of life.

Clinical Implementation of PSMA-PET Guided Tumor Response-Based Boost Adaptation in Online Adaptive Radiotherapy for High-Risk Prostate Cancer.

Association of HOXB13 G84E With Prostate Cancer Among 592,158 Men.

Management of Locally Advanced Prostate Cancer: A Scoping Review of Contemporary Evidence and Emerging Approaches.

Multicenter Phase II Study of Olaparib and the ATR Inhibitor Ceralasertib in Metastatic Castration-Resistant Prostate Cancer (TRAP).

Multiomic assessments of LNCaP and derived cell strains reveal determinants of prostate cancer pathobiology.

Managing Drug Interactions with Enzalutamide in Patients with Prostate Cancer: A Podcast.

Association between insulin resistance and prostate volume: A 4-year analysis from the Reduction by Dutasteride of Prostate Cancer (REDUCE) Trial.

The Role of Oncology Nurses and Advanced Practice Providers in the Treatment of Patients With HRR-Deficient mCRPC Receiving Talazoparib Plus Enzalutamide: A Podcast.

High-Dose-Rate brachytherapy for salvage treatment of prostate cancer recurrence post-prostatectomy and radiotherapy: A multicenter retrospective analysis (HDR-REPOPRA) by UroGEC.

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules.

Impact of Diabetes and Metformin on Cardiovascular Outcomes in Prostate Cancer Patients Aged 66 and Older: The Role of Social Determinants of Health and Racial Disparities †.

Comparing the safety and efficacy of systemic therapies for high-risk biochemically recurrent hormone-sensitive prostate cancer: a network meta-analysis.

Comparing the safety and efficacy of systemic therapies for high-risk biochemically recurrent hormone-sensitive prostate cancer: a network meta-analysis.

Tailoring Treatment in Localized Prostate Cancer: Comparative Effectiveness of HIFU, Cryoablation, and Robot-Assisted Radical Prostatectomy at 2-Year Follow-Up: Insights from Prospective Institutional Cohort.

MRI-fusion biopsy era: the role of perineural invasion in low-risk prostate cancer.

SPARC: The Standardised Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Analysis and Reporting Consensus: A Delphi Analysis.

A Narrative Review of Treatment Options for Patients with Node-Positive Disease After Radical Prostatectomy: Current Evidence and Controversies.

Comparative Economic Evaluation of Radical Prostatectomy, Radiation, and Ablative Techniques in the Management of Localized Prostate Cancer.

Prognostic Significance of PTEN Loss in Prostate Cancer: A Meta-Analysis of Gleason Grade and Clinical Outcomes.

Artificial Intelligence-Assisted Biparametric MRI for Detecting Prostate Cancer-A Comparative Multireader Multicase Accuracy Study.

A randomized Phase II trial of High Dose-Rate (HDR) and Low Dose-Rate (LDR) brachytherapy as monotherapy in localized prostate cancer: analysis of initial arms of Canadian cancer trials group PR19 (NCT02960087).

Anxiety and Health-related Quality of Life in Men with Prostate Cancer Undergoing Focal Therapy: A Prospective Single-arm Phase 2 Trial.

Ultrahypofractionated radiotherapy in one or two sessions for localized prostate cancer: a review of the evidence and future perspectives.

Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis: The PRIME Diagnostic Clinical Trial.

Algorithm to detect ISUP ≥ 2 prostate cancer using canine detection.

Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer.

Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7-Expressing CRPC Models.

BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature-positive castration-resistant prostate cancer.

Prostate Specific Membrane Antigen Focal Ablation Imaging (PSMA-FAB) - Beyond the Abstract

Upper Tract Tumors

Discovery of TBK1-Associated Oncogenic Mechanisms in Patients With Upper Tract Urothelial Carcinoma and Pre-Existing End-Stage Renal Disease.

Efficacy and safety of modified laparoscopic single-position radical nephroureterectomy with bladder cuff resection for upper urinary tract urothelial carcinoma: A single-center retrospective study.

The Impact of Patient, Tumor, and Socioeconomic Characteristics on Survival in Upper Urinary Tract Urothelial Carcinoma (UTUC): A Population-Based Registry Study from Hamburg, Germany (2004-2021).

Testicular Cancer

Immunohistochemical expression of Nectin-4 and potential implications for enfortumab vedotin therapy in germ cell tumors of the testis: a preliminary study.

Retroperitoneal lymphadenectomy (RPLND) for the treatment of testicular germ cell tumors-open or robotic? Pro open surgery : RPLND in the management of testis cancer.

Role of radiotherapy in the management of testicular cancer: Recommendations from the French society for radiation oncology.

Physical morbidities in survivors of testicular germ cell tumors during childhood, adolescence, and young adulthood: a population-based retrospective matched cohort study.

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