UroAlert - GU Oncology Weekly

September 04, 2025

Videos

Peer-to-Peer Clinical Conversations

Consensus Recommendations for ARPI Sequencing and Radioligand Therapy in mCRPC - Michael Morris

Michael J. Morris

Alan Bryce hosts Michael Morris to discuss mCRPC consensus recommendations from the 2024 US Prostate Cancer Consensus Conference.

Cost-Effectiveness Comparison of Bladder Preservation vs Radical Surgery - Daniel Joyce

Daniel Joyce

Leslie Ballas is joined by Daniel Joyce to discuss his cost-effectiveness analysis comparing trimodal therapy versus radical cystectomy for muscle-invasive bladder cancer.

Beyond the Abstracts

What Motivates Bladder Cancer Patients to Be Active? A Qualitative Study Assessing Attitudes Towards Physical Activity and Digital Health Technologies - Beyond the Abstract

Metastatic Renal Cell Carcinoma: Synchronous vs. Metachronous Metastatic Disease and Its Impact on Cancer Control in the IO-Combination Era-Real World Experiences from a Multi-Institutional Cohort - Beyond the Abstract

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

A population-based analysis of patterns of care in patients with de novo muscle-invasive bladder cancer from Alberta, Canada.

The current role of photodynamic diagnosis (PDD) in the management of non-muscle invasive bladder cancer: the Italian Society of Urology (SIU) Position Paper.

Impact of Preoperative CT-Diagnosed Sarcopenic Obesity on Outcomes After Radical Cystectomy for Bladder Cancer.

Risk Stratification Using a Perioperative Nomogram for Predicting the Mortality of Bladder Cancer Patients Undergoing Radical Cystectomy.

Microbiome Shifts in Bladder Cancer: A Narrative Review of Urobiome Composition, Progression, and Therapeutic Impact.

Neoadjuvant PD-1/PD-L1 Inhibitors for Muscle-Invasive Bladder Cancer: A Meta-Analysis.

Role of radiotherapy in the management of bladder cancer: Recommendations of the French Society for Radiation Oncology, 2025 update.

TAR-200 plus cetrelimab versus cetrelimab monotherapy as neoadjuvant therapy in patients with muscle-invasive bladder cancer who are ineligible for or decline neoadjuvant cisplatin-based chemotherapy (SunRISe-4): interim analysis of a randomised, open-lab

Defining statistical cure in patients with T1 high-grade non-muscle-invasive bladder carcinoma treated with BCG immunotherapy.

Gene Expression in Muscle-Invasive and Non-Muscle-Invasive Bladder Cancer Cells Exposed to Hypoxia.

Delayed vs. Concomitant Urethrectomy for Non-Metastatic Urothelial Carcinoma of the Urinary Bladder Undergoing Radical Cystectomy: Perioperative and Survival Outcomes from a Single Tertiary Centre in the United Kingdom.

National Trends in Diagnoses of Subtype Histologies in Bladder Cancer: A Population-Based Study Based on the SEER Database - Beyond the Abstract

Penile & Urethral Cancers

Oncological outcomes and organ preservation after brachytherapy for penile carcinoma: A multicentric retrospective study by the Brachytherapy Group of the French Society for Radiation Oncology.

CircRNA Sequencing Analysis Reveals the Regulatory Role of circ_CDR1as in Penile Squamous Cell Carcinoma via the ceRNA Network.

Renal Cancer

TRIM63 Overexpression in FISH-Negative MiTF Family Altered Renal Cell Carcinoma (MiTF RCC).

The Influence of Lymphovascular Invasion on T Stage Upstaging and Overall Survival in Renal Cell Carcinoma: A Population-Based Study.

Impact of first-line dual immuno-oncology combination therapy versus immuno-oncology plus tyrosine kinase inhibitor on outcomes of second-line VEGFR-TKI in advanced RCC: a real-world multi-institutional analysis.

Profiling autoantibodies at baseline and during immune checkpoint inhibitor therapy of renal cell carcinoma patients-exploratory results from TITAN-RCC.

Adoption and perioperative outcomes of single-port (SP) robotic partial nephrectomy in the state of Michigan: a MUSIC-KIDNEY analysis.

A comparative analysis of pre-operative factors, intra-operative events and post-operative outcomes assessing transperitoneal and retroperitoneal approaches for robotic partial nephrectomy in T1 renal cancer: a multicenter international experience.

Analysis of Peroxisomal ABCD3 Transporter as a Prognostic Factor in Clear Cell Renal Cell Carcinoma.

Circulating kidney injury molecule-1 (KIM-1) and association with outcome to adjuvant immunotherapy in renal cell carcinoma.

Urine Glycosaminoglycan Scores for Surveillance of Recurrence in Intermediate- and High-risk Nonmetastatic Clear Cell Renal Cell Carcinoma-An Observational Prospective Multicentre Diagnostic Test Cohort Study.

Are We Accurately Predicting Mortality in Renal Cancer? A Systematic Review of Prognostic Models.

Prostate Cancer

Depend® Teams Up with Ken Griffey Jr. & Sr. to Inspire Early Detection and Open Conversation Around Prostate Cancer

Establishing consensus recommendations for metastatic hormone-sensitive prostate cancer in South Korea: A modified Delphi study.

Integrated control of cancer stemness by σ1 receptor in advanced prostate cancer.

Ancestry-Dependent Immunologic and Prognostic Effects Characterize the Prostate Cancer Urinary Proteome.

Predicting the indication for adjuvant radiation therapy according to EAU guidelines among patients with high-risk prostate cancer: a novel multivariable model.

Examining the association between real-world extended vs. standard pelvic lymph node dissection and early and late oncologic outcomes in men undergoing radical prostatectomy.

Prevalence of germline pathogenic variants in 779 patients with metastatic prostate cancer.

Factors Associated with Recovery of Urinary Continence: A Multicenter Comparison of Pelvic Fascia-sparing and Standard Robotic-assisted Radical Prostatectomy - Beyond the Abstract

Single- versus multi-model in the deep learning prediction of monitor units per control point for automated treatment planning in prostate cancer.

Cost-effectiveness of talazoparib plus enzalutamide as first-line therapy in metastatic castration-resistant prostate cancer.

Combining PSMA-Targeted Radiopharmaceutical Therapy with Immunotherapy.

Comparative Performance of the CamPROBE Local Anaesthetic Transperineal Biopsy Device Versus an In-Line Device for Detection of Significant Prostate Cancer.

Reassessing the Evidence: Is Intensified Therapy Justified in Older Patients with Metastatic Hormone-Sensitive Prostate Cancer?

Determinants of oncologic outcomes in high-grade organ-confined prostate cancer after prostatectomy.

Reduced recurrence of prostate cancer with novel autologous cancer vaccine (FK- PC101) post-prostatectomy: long-term results from a single-center phase 1/2 study.

Randomized Phase 2 Trial of an Extended and Flexible Dosing Schedule of 177Lu-PSMA Molecular Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT): Study Protocol.

Rectal spacer use and overall long-term healthcare costs: payer perspective.

AI-driven body composition monitoring and its prognostic role in mCRPC undergoing lutetium-177 PSMA radioligand therapy: insights from a retrospective single-center analysis.

Neurovascular bundle preservation improves postoperative continence recovery in robotic-assisted laparoscopic radical prostatectomy after neoadjuvant hormonal therapy in the treatment of locally advanced prostate cancer: results from a propensity score-ma

The Oncometabolite 2-Hydroxyglutarate Is Upregulated in Post-Prostatectomy PSA Recurrence of Prostate Cancer: A Metabolomic Analysis.

Automated electronic medical record abstraction algorithm for radical prostatectomy outcomes.

Anticipated Out-Of-Pocket Costs and Prostate Cancer Management Among Men With Commercial Insurance.

Directed Evolution Restored Castrate Sensitivity in a Patient With Castrate Resistant Metastatic Prostate Cancer.

Disparities in radiation treatment modality for prostate cancer.

Treatment Patterns and Outcomes in Lymph-Node-Positive (pN1) Prostate Cancer: A National Cancer Database Study.

MUlticentre REtrospective comparison of definitive EBRT with or without HDR BRAchytherapy boost in patients with locally-advanced prostate cancer and regional lymph NOde metastases (MUREBRANO) - A propensity score matched analysis.

HOMER3 orchestrates SRC-YAP1 activity that promotes tumor cell growth and antagonizes anti-tumor immunotherapy in prostate cancer.

Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses.

Identification of asporin as a HER3 ligand exposes a therapeutic vulnerability in prostate cancer.

Patterns of HER2 Expression in Metastatic Prostate and Urothelial Cancers: Implications for HER2-Targeted Therapies.

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L.

Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers.

Prognostic Value of Automated Bone Scan Index (aBSI) in Patients with mCRPC Undergoing Three vs. Six Cycles of 223Ra Therapy.

Differential prognostic impact of favourable prostate cancer pathology risk score patterns predicted by Briganti's 2012 nomogram across EAU risk groups: Analysis of 757 cases treated with robotic surgery.

Complications of anatomical endoscopic enucleation of the prostate in real-life practice: What we learnt from the 6,193 patients from the Refinement in Endoscopic Anatomical enucleation of Prostate registry.

Prognostic Value of Preoperative Hemoglobin in Patients Undergoing Radical Prostatectomy for Localized Prostate Cancer.

Integrating Apparent Diffusion Coefficient and Prostate-Specific Antigen as Prognostic Factors of Treatment Response to Androgen Deprivation Therapy and Radiotherapy in Prostate Cancer.

Development of an in Situ CAR-T Cell Protocol Through Optical and PSMA-Targeted PET Imaging - Beyond the Abstract

Acute Toxicity of SBRT in Localized Prostate Cancer: A Spanish Multicenter Study - Beyond the Abstract

Efficacy of Anti-PD-(L)1 Immunotherapy in Patients with DNA Mismatch Repair-deficient Metastatic Castration-resistant Prostate Cancer - Beyond the Abstract

The Natural History of Confirmed Grade Group 1 Prostate Cancer Managed with Active Surveillance in the Modern Era - Beyond the Abstract

Long-Term Outcomes of Radiotherapy and Impact of Nodal Disease Burden in Clinically Node-Positive Prostate Cancer - Beyond the Abstract

Integrating Anamnestic and Lifestyle Data with Sphingolipid Levels for Risk-Based Prostate Cancer Screening - Beyond the Abstract

Prognostic Value of Posttherapy SPECT/CT for Overall Survival in Patients Undergoing [177Lu]Lu-PSMA-617 Radiopharmaceutical Therapy: Results from 3 Clinical Trials - Beyond the Abstract

Engaging for Equity: Lessons from a Cross-Sector Partnership Addressing Prostate Cancer Risk in the Black Community - Beyond the Abstract

Upper Tract Tumors

Radical nephroureterectomy vs kidney sparing surgery for upper tract urothelial carcinoma in solitary kidney patients: a multi-institutional analysis of the ROBUUST 2.0 registry.

Clinical Consultation Guide: Neoadjuvant Chemotherapy for Upper Tract Urothelial Cancer.

Genetic profiling of upper tract urothelial carcinoma: a necessity for precision medicine.

Machine Learning-Based Gene Expression Analysis to Identify Prognostic Biomarkers in Upper Tract Urothelial Carcinoma.

Testicular Cancer

The effect of testicular self-examination education on health beliefs in adult men: a systematic review and meta-analysis.

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