UroAlert - GU Oncology Weekly

August 28, 2025

Videos

Peer-to-Peer Clinical Conversations

Non-Invasive Monitoring Options for Bladder Cancer Patients - Kristen Scarpato

Kristen Scarpato

Ashish Kamat interviews Kristen Scarpato about non-invasive bladder cancer monitoring alternatives to cystoscopy.

ctDNA Biomarkers in TheraP Trial: Cabazitaxel vs Lutetium-PSMA Comparison - Alexander Wyatt

Alexander Wyatt

Oliver Sartor speaks with Alexander Wyatt about circulating tumor DNA biomarkers in the TheraP trial, which compared cabazitaxel versus lutetium-177 PSMA-617 in heavily pre-treated prostate cancer patients.

Beyond the Abstracts

Elevating the Patient Voice: Understanding Treatment Preferences in Patients with Advanced Prostate Cancer - Beyond the Abstract

Clonal Hematopoiesis in Metastatic Urothelial and Renal Cell Carcinoma - Beyond the Abstract

Conference Coverage

BCANTT 2025: Exploring Therapeutic Vulnerabilities for Drug Development in Bladder Cancer Using down Syndrome as a Novel Model

BCANTT 2025: Bio-Digital Avatars for Personalized Sequencing of Bladder Cancer Therapies

AUA 2025: Which Are the Prognostic Implications of a Negative PSMA-PET at the Time of Biochemical Recurrence in Prostate Cancer Patients Treated With Radical Prostatectomy? Selection of Salvage Therapies Candidates

PSMA and Beyond 2025: Keynote Lecture: Improving Outcomes with Combination Therapy

PSMA and Beyond 2025: Opportunity for RLT in Bladder Cancer

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

Comparative efficacy of holmium laser versus plasma techniques in the surgical management of non-muscle invasive bladder cancer: a meta-analysis.

A comparative study of perioperative outcomes in open radical cystectomy, laparoscopic radical cystectomy, and robotic-assisted radical cystectomy.

Physical activity matters: prognostic impact of preoperative functioning scores in patients undergoing radical cystectomy.

Antibody-drug conjugates for non-muscle invasive bladder cancer: current status and future development.

Small cell carcinoma of the bladder: Review of pathogenesis, presentation, and management.

Molecular classification of nonurothelial histologic subtypes of bladder cancer.

The value of maintenance therapy in intermediate-risk non-muscle-invasive bladder cancer.

Clinical and Pathological Predictors for Occult Lymph Node Involvement in Patients With Clinical Node-Negative Bladder Cancer Undergoing Radical Cystectomy.

Evaluating surrogates for overall survival in the adjuvant treatment of bladder cancer with chemotherapy.

The Effect of Chronic Liver Disease on Adverse In-Hospital Outcomes After Radical Cystectomy and Ileal Conduit Urinary Diversion.

BCG Intolerance in Nonmuscle Invasive Bladder Cancer-A Systematic Review.

The Impact of a Multidisciplinary Approach on Treatment Decisions and Outcomes in Urothelial Carcinoma: A Systematic Review - Beyond the Abstract

Effect of Sex on Adverse In-Hospital Outcomes after Radical Cystectomy According to Urinary Diversion Type - Beyond the Abstract

Renal Cancer

Biopsy-all strategy in patients with a renal mass: simulation of a randomised controlled trial.

Bilateral, multicystic fumarate hydratase-deficient renal cell carcinoma in patient with hereditary leiomyomatosis & renal cell carcinoma syndrome: A case report and review of the literature.

AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma.

Novel radiopharmaceuticals for molecular imaging of renal cell carcinoma.

Temporal Trends and Socioeconomic Determinants of Cytoreductive Nephrectomy Utilization for Metastatic Renal Cell Carcinoma in the USA.

Longitudinal Patterns of Cardiovascular Disease and Cancer Mortality in Renal Cell Carcinoma Patients by Tumor Stage.

Life Expectancy of Renal Cell Carcinoma with Variant Histology.

Immunotherapy in Renal Cell Carcinoma.

Incidence of local treatment and metastasis during active surveillance for patients with a small renal mass in a national multicenter prospective cohort.

Interleukin-8 as a potential prognostic biomarker in Renal Cell Carcinoma: A systematic review and Meta-Analysis.

Impact of body mass index on the efficacy of immune combination therapy in metastatic renal cell carcinoma: a multicenter study in Japan.

Vigorous Physical Activity as a Potential Environmental Risk Factor in Renal Medullary Carcinoma - Beyond the Abstract

Prostate Cancer

Medicare Part D Redesign Savings May Be Lower For Beneficiaries With Spending Below The Out-Of-Pocket Cap

Apalutamide Monotherapy in Metastatic Hormone-Sensitive Prostate Cancer: A Viable Alternative to First-Generation Anti-Androgen Agents to Avoid the Flare Phenomenon and an Effective Treatment for Achieving Early PSA Response.

Comparison of online adaptation strategies for magnetic resonance guided prostate radiation therapy.

Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer.

Prognostic Impact of Time to Castration Resistance on Overall Survival in Patients With Metastatic Castration-Sensitive Prostate Cancer.

ProMUS-NET: Artificial intelligence detects more prostate cancer than urologists on micro-ultrasonography.

Cellular cartography reveals mouse prostate organization and determinants of castration resistance.

Radioligand treatment with [177Lu]Lu-PSMA I&T in elderly Patients - Safety, efficacy, and prognostic factors for survival.

Biobehavioral correlates of multidimensional fatigue in men with prostate cancer: A secondary data analysis.

Population-Specific Radiomics From Biparametric Magnetic Resonance Imaging Improves Prostate Cancer Risk Stratification in African American Men.

Ten-year survival rates by PSA nadir in patients with metastatic hormone-sensitive prostate cancer: long-term survival analysis from the ECOG-ACRIN 3805 (CHAARTED) trial.

Development and validation of a natural language processing system to assess quality of physician communication in prostate cancer consultations.

Sociodemographic Features, Health Care Costs, and Treatment Implications of Genomic Classifier Testing for Localized Prostate Cancer in the United States.

Systems biology successes and areas for opportunity in prostate cancer.

Statin Use in Patients With Advanced Prostate Cancer in the TITAN and SPARTAN Trials.

Radiological T-staging in prostate Cancer: Towards a universal MRI-based scoring system.

The Prognostic Role of 68GA-PSMA-PET/CT in Metastatic Hormone-Sensitive Prostate Cancer: A Preliminary Analysis.

Bias in deep learning-based image quality assessments of T2-weighted imaging in prostate MRI.

A Deep Prostate-specific Antigen Response to Darolutamide plus Androgen Deprivation Therapy Is Associated with Better Clinical Outcomes in the Phase 3 ARANOTE Trial in Patients with Metastatic Hormone-sensitive Prostate Cancer.

Novel Biopsy Gun Impacts Biopsy Sample Quality and Quantity

The utility of next-generation sequencing in metastatic prostate cancer FNA biopsies.

The emerging role of PARP inhibitors in prostate cancer: A narrative review.

Treatment variations in localised prostate cancer in Australia and New Zealand: a registry study.

Refining prognostic stratification in salvage radiotherapy for prostate cancer: A retrospective multicenter cohort study using PSMA-PET and machine learning.

Evaluation of the 4Kscore test in relation to subsequent risk of aggressive prostate cancer in the European Prospective Investigation into Cancer and Nutrition.

Epigenetic De-repression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression.

Optimisation of Low and Ultra-Low Dose Scanning Protocols for Ultra-Extended Field of View PET in a Real-World Clinical Setting

Augmented reality assisted MRI/US fusion for non-rectal fully trans-perineal prostate biopsy.

The potential of generative AI with prostate-specific membrane antigen (PSMA) PET/CT: challenges and future directions.

Impact of treatment suspension on health-related quality of life in the EMBARK trial: a post hoc analysis.

Dietary Patterns in Prostate Cancer Prevention and Management: A Systematic Review of Prospective Cohort Studies and Randomized Clinical Trials.

History of Vasectomy Is Not Associated with Prostate Cancer Progression in Men on Active Surveillance - Beyond the Abstract

Evaluating the Safety of Delaying Surgery Beyond 9 Months in Localized Prostate Cancer Patients: Results From a Prospective Study With Propensity Score Matching - Beyond the Abstract

Upper Tract Tumors

Outcomes of endoscopic management for upper tract urothelial carcinoma: A multi-center international cohort analysis.

Robot-assisted radical nephroureterectomy for locally advanced upper tract urothelial carcinoma: a multicenter study by the Junior ERUS/YAU Working Group on Robot-assisted Surgery.

Testicular Cancer

Tracking and analysis of testicular cancer burden in adolescents and young adults globally in Asia and in China: 1990-2021 epidemiological trends.

Salvage chemotherapy in the intensive care unit: a case report of successful treatment of a critically ill patient with metastatic testicular germ cell tumor.

Machine Learning Model Integrating Computed Tomography Image-Derived Radiomics and Circulating miRNAs to Predict Residual Teratoma in Metastatic Nonseminoma Testicular Cancer.

Potential therapeutic targets and biomarkers in testicular germ cell tumor oncogenesis.

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