WCE 2019: Impact of Demographic Factors and Systemic Disease on Urinary Stone Risk Parameters Amongst Stone Formers

Abu Dhabi, United Arab Emirates (UroToday.com) Dr. Kyle Wood and his colleagues’ objective was to determine, through multivariate analysis, the associations between various demographic factors and systemic diseases on stone risk parameters in a stone-forming population. To do this, the retrospectively examined 589 patients’ medical records at their institution between 2004 and 2015.

What Dr. Wood and his team found was that older age was associated with decreased calcium excretion, decreased supersaturation of calcium oxalate, decreased supersaturation of calcium phosphate, and increased urinary pH. Males excreted Diabetes was associated with more oxalate excretion. There were also positive correlations between BMI and calcium and oxalate excretion, as well as BMI and supersaturation of uric acid.

Dr. Wood also noted that UAB serves a large African American population in Birmingham, and was, therefore, able to characterize stone forming disease in a cohort that is historically poorly represented in the literature. His team noted that African Americans had lower urinary volumes (p = 0.0023), less calcium (p=0.0142) and oxalate (p = 0.0074) excretion, and higher supersaturation of uric acid (p = 0.0049). It is important to note these trends for proper interpretation of laboratory tests and patient counseling.

In conclusion, Dr. Wood and his colleagues demonstrated that both demographic factors and systemic disease are independently associated with numerous risk factors for kidney stones. These results highlight the differential risks for patients in developing stones, which warrant further investigation to illuminate the causes for these disparities.

Presented by: Kyle Wood, MD, Assistant Professor, Department of Urology, University of Alabama at Birmingham, Birmingham, AL

Written by: Lillian Xie, BA, Department of Urology, University of California, Irvine, California at the 37th World Congress of Endourology (WCE) – October 29th-November 2nd, Abu Dhabi, United Arab Emirates