TAT-11: Evaluation of Specific Activity and Stable Impurities in Ac-225 Derived from ISAC and 229Th Decay

Ottawa, ON, Canada (UroToday.com) Ms. Mynerich described a comparison of Ac225 from two different sources to investigate the role of stable impurities in radio-labeling with two common chelating agents. One source of Ac225 came from mass separation at TRIUMF’s ISAC/ISOL facility following 480 MeV proton bombardment of a Uranium target.

The second source came from a Th229 generator at CNL. The chelators used were H4DOTA and H2macropa. Specific activities of Ac225 of 44 kBq/nmol were obtained with DOTA and 4.4 MBq/nmol with macro papa. Some purity issues with the generator separation process at CNL have been resolved. Impurities in the ISAC sample coming from the etching of the aluminum target disk need to be addressed.


Presented by: Ms. Jenasee Mynerich, TRIUMF, McMaster University, Hamilton, Ontario, Canada

Written by: William Carithers, Lawrence Berkeley National Laboratory at the 11th International Symposium on Targeted Alpha Therapy (TAT-10)  April 1 - April 4, 2019 - Ottawa, ON, Canada