For the tumor studies, this ligand was linked to TCO functionalized bovine serum albumin (BSA) aggregates. The Ac225 or Lu177 labeled conjugate was injected directly into a 4T1 breast cancer model. There was a very high tumor uptake with the aggregates, justifying further studies.
Presented by: Ms. Stephanie Rathmann, McMaster University, Hamilton, Ontario, Canada
Written by: William Carithers, Lawrence Berkeley National Laboratory at the 11th International Symposium on Targeted Alpha Therapy (TAT-10) April 1 - April 4, 2019 - Ottawa, ON, Canada