TAT-10: High-resolution Alpha Camera imaging as a tool for developing Targeted Alpha Therapy

Kanazawa, Japan (UroToday.com) Alpha particle dose can be highly non-uniform within an organ so microdosimetry with high resolution imaging is required for accurate dosimetry measure. An alpha camera is described to accomplish this.

The tissue to be imaged is sectioned and placed on a scintillator. When charged particles deposit energy in a scintillator, the fluors are excited and emit light. This light is then lensed and detected with a cooled CCD camera. Since the alpha range is very short, the scintillator light is very localized so high resolution images can be obtained. The camera can be operated either in an integrating mode or in a quantum mode where single alphas can be seen as a function of time.

High resolution images have been obtained with a number of tissue types irradiated by Ra223, Th227, Bi223, and At211.

Small-scale tumor uptake was measured for biopsy samples taken from bone metastasis tumor from a castration-resistant prostate cancer patients.

Presented By: Tom Bäck from Department of Radiation Physics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Written By: William Carithers, Lawrence Berkeley National Laboratory

at the 10th International Symposium on Targeted Alpha Therapy (TAT-10)  May 31 - June 1, 2017 - Kanazawa, Japan.

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