Phantoms containing known amounts and shapes of Ra223 in containers were used to optimize the adjustable parameters (angular and energy range) of the SPECT instrument. A 5.6ml sphere containing 20 kBq/ml showed quantitative accuracy of about 4%.
Ra223 is usually used to treat bone metastases and bone has a highly complex structure. Moreover, bone marrow is an organ at risk so the details of dosimetry are very important. A comparison was made between the alpha absorbed fractions given in ICRP Publication 30 and a Monte Carlo (MCNP6) calculation using a realistic volexized model of an adult male skeleton developed by the University of Florida. Differences of up to 50% were observed
Presented By: Nadia Benabdallah from IRSN, Institute for Radiological Protection and Safety, Paris, France
Written By: William Carithers, Lawrence Berkeley National Laboratory
at the 10th International Symposium on Targeted Alpha Therapy (TAT-10) May 31 - June 1, 2017 - Kanazawa, Japan.