SUO 2018: Qualitative and Quantitative Evidence of Sipuleucel-T Induced PAP and PA2024 Specific CD8+ Cytolytic Response and its Association with Overall Survival
Dr. Kibel summarized his groups findings that cytolytic activity showed statistically significant increases at weeks 6 and 26, with the degree of cytolytic activity correlated with overall survival rates. Video evidence was provided at these time points where CD8+ T cells migrated toward PAP target cells, resulting in cell death. Additionally, cell destruction was not observed in cells which did not express PAP.
This study is thought-provoking as it provides evidence and the potential mechanism of action of sipuleucel-T induced PAP specific CT8 T cell mediated responses. Moreover, the degree of OS and magnitude of cytolytic activity has been correlated.
Presented By: Adam S. Kibel, MD
Written by: David B. Cahn, DO, MBS, Fox Chase Cancer Center, Philadelphia, PA, @dbcahn, at the 19th Annual Meeting of the Society of Urologic Oncology (SUO), November
28-30, 2018 – Phoenix, Arizona