SUFU 2020: Paralyzing Pain: Intradetrusor Botulinum Toxin A Injection Via Flexible Cystoscopy for Treatment of Interstitial Cystitis

Scottsdale, AZ ( Dr. Lauren Gleich presented their research on whether botulinum toxin (BTX A) injection via flexible cystoscopy as an outpatient/clinical procedure for Interstitial cystitis (IC) leads to subjective patient improvement of symptoms. 

They performed a retrospective chart review and identified 989 patients who were diagnosed with IC. 21 of these patients had BTX A injections and 18 were included in analysis. Patients had previously failed 1-3 line treatments for IC. Patients underwent the injection via local or monitored anesthesia care (MAC). Injection consisted of 100 units in ½ cc increments for a total of 20 injections. There were multiple urologists involved. The primary endpoint was to assess patient improvement of IC symptoms. Secondary endpoints included the type of anesthesia, timer interval between injections and amount of BTX A.

Their results are displayed below:


Overall they found that 12/18 patients reported improvement, this has a p=0.001. The symptoms are not known. They conclude this is the first study to report the successful administration of BTX A in the office or with MAC for IC patients with improvement of symptoms. She mentions several limitations including the lack of validated questionnaire, retrospective nature, and the small sample size.

Presented by: Lauren D. Gleich, DO, BS, Resident Doctor, Rowan University School of Osteopathic Medicine, Stratford, New Jersey

Written by: Lira Chowdhury, DO, Urology Specialist, Urology Partners of North Texas, PLLC, Fort Worth, Texas at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction Winter Meeting, SUFU 2020, February 25 - February 29, 2020, Scottsdale, Arizona