Background: The bone-targeting agents (BTAs) denosumab and bisphosphonates (BPs) are widely used in the supportive care of patients (pts) with CRPC and bone metastases. We present data on pts treated with radium-223 dichloride (Ra-223) with or without a concomitant BTA in an international EAP.
Results: 696 pts received at least one Ra-223 cycle. Of those, 127 (18%) pts were treated with concomitant denosumab (no BPs) and 435 (63%) without concomitant BTAs. Key baseline characteristics are reported in pts treated with Ra-223 with or without a concomitant BTA (Table). Median OS (mOS) and median time to first SSE (mSSE) were longer in pts treated with Ra-223 and denosumab versus pts without a concomitant BTA (Table). While key baseline characteristics in pts treated with Ra-223 and denosumab were similar to pts treated with Ra-223 and BPs (no denosumab, 125 [18%] of 696), adding BPs to Ra-223 did not appear to improve mOS. However, mSSE was prolonged in pts receiving Ra-223 and BPs versus pts who received Ra-223 without a concomitant BTA (Table).
Conclusions: In this EAP, pts treated with Ra-223 and a concomitant BTA appeared to have longer time to first SSE than those treated without a concomitant BTA. However, improvement in OS with a BTA was observed with denosumab but not with BPs. Prospective randomized controlled studies are required to confirm the benefit of this specific treatment combination in metastatic CRPC.
Neal Shore, Carolina Urologic Research Center, Myrtle Beach, SC, USA; Axel Heidenreich, University Hospital, University Hospital Cologne, Germany; Daniel Heinrich Akershus University Hospital, Lørenskog, Norway; Daniel Kejzman, Meir Medical Center, Kfar-Saba, Israel; Joe M. O’Sullivan, The Centre for Cancer Research and Cell Biology, Belfast, Northern Ireland; Joan Carles Vall d’ Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, Spain; Manfred Wirth, University Hospital Carl-Gustav Carus, Dresden, Germany; Kurt Miller, Charité University Medicine Berlin, Berlin, Germany; Monica Seger-Van Tol, Pharmaceutical Division of Bayer, Whippany, New Jersey, USA; Sten Nilsson, Karolinska University Hospital, Stockholm, Sweden; Silke Gillessen, Kantonsspital St Gallen, St Gallen, Switzerland; Fred Saad, University of Montreal Hospital Centers, Montreal, Canada