IBCN 2020: Lytic Effects of Water on Bladder Cancer Cell Lines: Implications For Clinical Use of Water Irrigation to Reduce Recurrence

(UroToday.com) Dr. Shomik Sengupta, Eastern Health, Melbourne, Australia presented “Lytic Effects of water on bladder cancer cell lines: implications for clinical use of water irrigation to reduce recurrence.”  The investigators present a companion systematic review of continuous washout of the bladder (CBI) utilization for nonmuscle-invasive bladder cancer (NMIBC) recurrence prevention. 

3 randomized controlled trials (RCTs) comparing CBI (saline or water) vs. perioperative chemotherapy detected no differences in the modalities to prevent NMIBC recurrence.  Dr. Sengupta et al. then performed in vitro investigation of cell viability when exposed to common bladder irrigants (water, saline, glycine).  Water led to rapid cell lysis, with no detectable cells remaining by 10-20 minutes, compared to saline and glycine which were associated with a slower loss in cell viability.  This promising data needs in vivo characterization in terms of efficacy as well as cost and tolerability compared to perioperative chemotherapy.


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Presented by: Shomik Sengupta, FRACS, consultant urologist, Eastern Health, Melbourne, Australia 

Written by: Dr. Patrick Hensley, Urologic Oncology Fellow at MD Anderson Cancer Center, Twitter: @pjhensley11, with Ashish Kamat, MD, MBBS, President of The International Bladder Cancer Network (IBCN), The International Bladder Cancer Group (IBCG), and Professor of the Department of Urology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, Twitter: @UroDocAsh, at the International Bladder Cancer Network (IBCN) Annual Meeting, #IBCN2020, October 17, 2020.
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