EAU 2018 - Prostate Specific Antigen (PSA) Response in Men With Nonmetastatic Castration-Resistant Prostate Cancer (M0 CRPC) Treated With Enzalutamide: Results From PROSPER

Copenhagen, Denmark (UroToday.com) M0 CRPC or nmCRPC is an area of unmet need. Development of metastases is associated with increasing baseline PSA and PSA doubling time <10 months. 2-3  Median metastasis-free survival (MFS) was 25-30 months in the placebo arms of several randomized controlled trials.1-3  Delaying time to all metastases is clinically relevant, with potential to delay cancer-related morbidity and prolong overall survival (OS). Enzalutimide significantly improved OS and radiographic progression-free survival (rPFS) in men with chemotherapy-naive M1 CRPC in the phase 3 PREVAIL study. 5 Enzalutimide was superior to bicalutamide in improving rPFS in the subgroup of patients with chemotherapy-naive M0 CRPC in the phase 2 STRIVE study. 6 We hypothesized that enzalutimide will delay metastases development in men with M0 CRPC and rapidly rising PSA (PSA doubling time 2265≤ 10 months). 

Poster Sternberg PROSPER PSA EAU2018 030918aClick Image to Enlarge

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