EAU 2018: Urogenital Tuberculosis: The Cause Of Ineffective Antibacterial Therapy For Urinary Tract Infections

Copenhagen, Denmark (UroToday.com) Dr. Kulchavenya, a clinical urologist from the Novosibirsk Research TB Institute, Novosibirsk Medical University, Dept. of Urology, presented on antibiotic resistance and bacterial strain similarities found in those diagnosed with a long history of urinary tract infection (UTI) and suspicious for urogenital tuberculosis (UGBT). UGTB has no specific symptoms, therefore there are currently no screening methods for early detection. However, UTIs are considered first line for differential diagnosis with UGTB.

In the open non-comparative prospective study, 244 consecutive patients with recurrent UTIs suspicious for UGTB were enrolled. All patients experienced at least 5 courses of ineffective antibiotic treatment. Urine samples were evaluated for bacterial growth and strains with growth of 104 CFU/mL were considered for antibiotic resistance. Many strains exhibited antibiotic resistance. Furthermore, among those in the patient cohort, 63 were diagnosed with UGTB and 43 were diagnosed with both UTI and UGTB.

In conclusion, Dr. Kulchavenya reiterated the poor results of antibacterial therapy and the high co-morbidity of UTI and UGTB diagnosed. Therefore, the ineffectiveness of standard antibacterial therapy of UTI should be an indication of the need for a UGTB examination.

Speaker: Dr. Kulchavenya

Authors: Kulchavenya E., Cherednicenko A.

Written by: Whitney Zhang, Department of Urology, University of California-Irvine, at the 2018 European Association of Urology Meeting EAU18, 16-20 March, 2018 Copenhagen, Denmark