UroAlert - GU Oncology Weekly

August 07, 2025

Videos

Peer-to-Peer Clinical Conversations

BOND-003 Trial Results in BCG Unresponsive Non-muscle Invasive Bladder Cancer - Mark Tyson

Mark Tyson

Zachary Klaassen hosts Mark Tyson to discuss the BOND-003 trial evaluating cretostimogene for BCG-unresponsive NMIBC.

AUA Microhematuria Guidelines 2025 - Daniel Barocas

Daniel Barocas

Zachary Klaassen interviews Daniel Barocas on the AUA/SUFU microhematuria guideline update.

Beyond the Abstracts

Hiding in the Kidney: A Series of 13 Lymphoid Proliferations Clinically Mimicking Renal Carcinoma - Beyond the Abstract

Tailored Use of PSA Density According to Multiparametric MRI Index Lesion Location: Results of a Large, Multi-Institutional Series - Beyond the Abstract

Physician-Scientist Review Articles

ERBB2 Alterations in Circulating Tumor DNA in Patients with Metastatic Urothelial Cancer - Expert Commentary

Oncolytic Adenoviral Therapy in Combination with Nivolumab in Muscle-Invasive Bladder Cancer - Expert Commentary

Articles

Editor Selected Abstracts and Commentaries

Bladder Cancer

Neoadjuvant Pembrolizumab and Accelerated Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Nonurothelial Histologic Subtypes of Muscle-invasive Bladder Cancer: A Phase 2 Trial.

Muscle-Invasive Bladder Cancer: A Watershed Moment.

Tolerability and efficacy of induction Bacillus Calmette-Guérin for non-muscle invasive bladder cancer.

Cost-effectiveness analysis of perioperative durvalumab plus platin-based chemotherapy in muscle invasive bladder cancer in Germany.

Urinary Tumor DNA-based Liquid Biopsy in Bladder Cancer Management: A Systematic Review.

Attendings versus supervised residents: Educational results and future perspective in transurethral resection of bladder tumors.

The Evolving Landscape of Systemic Immunotherapy for Bacillus Calmette-Guérin-naïve High-risk Non-muscle-invasive Bladder Cancer: At the Edge of a Tsunami?

Shaping the Future of Personalized Therapy in Bladder Cancer Using Artificial Intelligence.

An RMST-based analysis of systemic therapy in muscle-invasive bladder cancer.

Comparative Assessment of Chemotherapy Followed by Consolidative Radical Cystectomy Versus Chemoradiation for Clinically Node-Positive Urothelial Carcinoma of the Bladder.

TAR-200 for Bacillus Calmette-Guérin-Unresponsive High-Risk Non-Muscle-Invasive Bladder Cancer: Results From the Phase IIb SunRISe-1 Study.

What Motivates Bladder Cancer Patients to Be Active? A Qualitative Study Assessing Attitudes Towards Physical Activity and Digital Health Technologies - Beyond the Abstract

Penile & Urethral Cancers

Penile carcinoma: the importance of histological classification and new treatment strategies.

Renal Cancer

Genomic and molecular associations with preoperative immune checkpoint inhibition in patients with stage III clear cell renal cell carcinoma.

Risk Factors for First-Year Recurrence in Patients with Synchronous Metastatic Renal Cell Carcinoma Undergoing Cytoreductive Nephrectomy and Complete Metastasectomy.

Risk Stratification for the Prognosis of Patients With pT3aN0M0 Clear Cell Renal Cell Carcinoma.

Renal cancer survival in clear cell renal cancer compared to other types of tumor histology: A population-based cohort study.

Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma.

Predictive Clinical Features in Germline Testing for Renal Cell Carcinoma.

Epidemiology of Renal Cancer: Incidence, Mortality, Survival, Genetic Predisposition, and Risk Factors.

Pembrolizumab plus axitinib versus sunitinib for advanced clear cell renal cell carcinoma: 5-year survival and biomarker analyses of the phase 3 KEYNOTE-426 trial.

Immune-based Combinations in Intermediate-/Poor-risk Patients with Non-clear Cell Renal Cell Carcinoma: Results from the ARON-1 Study.

Impact of local therapy in metastatic renal cell carcinoma during medical treatment in a retrospective analysis.

Hiding in the Kidney: A Series of 13 Lymphoid Proliferations Clinically Mimicking Renal Carcinoma - Beyond the Abstract

A Comparison of Renal Cell Carcinoma with Tumor Thrombus Across North America, Central/South America, and South Korea - Beyond the Abstract

Pembrolizumab-Axitinib versus Nivolumab-Cabozantinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma: A Retrospective Real-World Comparison (ARON-1) - Beyond the Abstract

Quality Indicators for Renal Cancer Care: A Systematic Review - Beyond the Abstract

Clinical Outcomes and Safety Profile of Neoadjuvant PD-1 Inhibitors Combined With VEGFR-TKI versus VEGFR-TKI in Nonmetastatic Renal Cell Carcinoma - Beyond the Abstract

Prostate Cancer

Treatment choice and sexual health outcomes in gay and bisexual men with prostate cancer.

Surgical Wait Time Is Not Associated With Oncological or Psychosocial Outcomes After Robotic Radical Prostatectomy.

Proteomic profiling of extracellular vesicles distinguishes prostate cancer molecular subtypes.

Tumor Cholesterol Synthesis, Statin Use, and Lethal Prostate Cancer.

External Validation of the International Staging Collaboration for Cancer of the Prostate (STAR-CAP) Prognostic System in Patients Managed with Active Surveillance.

Lantheus Announces FDA Acceptance of NDA for New Formulation for Market-Leading PSMA PET Imaging Agent

Oncological safety of testosterone replacement therapy in men with localised prostate cancer: a systematic review of observational studies.

Prostate cancer germline variants with therapeutic implications.

Assessing the uptake of core outcome sets in randomized controlled trials for localized prostate cancer: A cross-sectional study.

Role of the Stockholm3 Test in Guiding Confirmation Biopsy Decisions for Patients with Prostate Cancer on Active Surveillance.

Association between major cardiovascular events and abiraterone acetate compared to enzalutamide in patients with metastatic castration-resistant prostate cancer: a post hoc analysis of the EVADE study.

Utilization of Incontinence Procedures Following Prostate Cancer Treatment: A Population-Level Analysis.

Continuous Androgen Deprivation Therapy with or Without Metastasis-directed Therapy for Oligometastatic Prostate Cancer: The Multicenter Phase 2 Randomized EXTEND Trial.

Dosimetric Clues to Addressing Urinary Toxicity Following Stereotactic Prostate Radiation Therapy.

Long term results of NRG Oncology RTOG 9601, a randomized trial of radiation with or without anti-androgens (AAT) in patients receiving salvage prostate bed radiation therapy post prostatectomy.

Prostate Specific Antigen Testing and Prostate Cancer Diagnosis Rates Among Transgender and Nonbinary Patients: Retrospective Review of a Single-Institution Experience.

Determining Optimal Patient Selection for High-intensity Focused Ultrasound for Prostate Cancer.

Prognostic and predictive value of baseline PSMA-PET total tumour volume and SUVmean in metastatic castration-resistant prostate cancer in ENZA-p (ANZUP1901): a substudy from a multicentre, open-label, randomised, phase 2 trial.

Review of Transperineal and Transrectal Prostate Biopsy Outcomes.

External evaluation of an open-source deep learning model for prostate cancer detection on bi-parametric MRI.

PKA-driven SPP1 activation as a novel mechanism connecting the bone microenvironment to prostate cancer progression.

Estimating the Carbon Emissions of a Single Prostate-specific Antigen Test: Results from a Cradle-to-grave Life Cycle Assessment.

Theranostics 2.0: Target-driven, artificial intelligence-enabled cancer therapy across tumor types.

Outcomes for [177Lu]Lu-PSMA-617 with and Without Concurrent Use of Androgen Receptor Pathway Inhibitors in Patients with Metastatic Castration-resistant Prostate Cancer.

In-Bore MRI-Guided Ureteral Stent Placement During Prostate Cancer Cryoablation-A Case Series.

Socioeconomic disparities in prostate cancer screening: the impact of the Area Deprivation Index on PSA screening frequency.

Preferences between three options for androgen deprivation therapy: a focus group study.

Clinical Trial Protocol for prePSMA: A Multicenter, Randomized, Noninferiority Trial of Preoperative Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography as Triage for Extended Pelvic Lymph Node Dissection in Patients Schedu

Prostate specific membrane antigen focal ablation imaging (PSMA-FAB).

Volumetric Changes and Acute Toxicity with 68Ga Prostate-Specific Membrane Antigen vs 18F-Fluciclovine PET/CT Guided Post-Prostatectomy Radiation: Final Analysis of a Randomized Trial.

Real-World Outcomes and Molecular Profiling for Patients with Metastatic Castration-resistant Prostate Cancer with Lung Metastases: A Long-term Multicenter Experience - Beyond the Abstract

Tailored Use of PSA Density According to Multiparametric MRI Index Lesion Location: Results of a Large, Multi-Institutional Series - Beyond the Abstract

Use of 177Lu Prostate-Specific Membrane Antigen Therapy in mCRPC: Joint Statement of the Austrian Society of Nuclear Medicine and Theranostics and the Austrian Society of Urology and Andrology - Beyond the Abstract

Upper Tract Tumors

Comparative survival outcomes of minimally invasive versus open radical nephroureterectomy for upper tract urothelial carcinoma in Taiwan.

Oncologic and survival outcomes in patients undergoing radical nephroureterectomy with preoperative or iatrogenic dialysis dependence.

Testicular Cancer

The role of primary RPLND in clinical stage IIA/B testicular germ cell tumor: a narrative review.

Therapy de-escalation for testicular cancer (THERATEST): A multi-centre observational cohort feasibility study of de-escalation therapies for good prognosis stage II germ cell tumours.

Risk Factors for Arterial Thromboembolic Events in Male Germ Cell Tumors Treated with Chemotherapy.

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