UroAlerts - Prostate Cancer Weekly

June 02, 2026

Videos

Peer-to-Peer Clinical Conversations

PROTEUS Trial: Neoadjuvant Apalutamide and Androgen Deprivation Therapy in High-Risk Localized Prostate Cancer - Mary-Ellen Taplin

Mary-Ellen Taplin

Mary-Ellen Taplin presents PROTEUS trial results.

Hydrogel Spacer Placement for Prostate Radiotherapy: A Urology Residency Training Experience - Zachary Klaassen

Zachary Klaassen

Zachary Klaassen discusses hydrogel spacer placement and resident education, drawing on approximately 250 Barrigel® procedures performed since FDA clearance in 2022.

Beyond the Abstracts

Lack of Survival Benefit of Pelvic Lymph Node Dissection for Patients with Radical Prostatectomy and Postprostatectomy Radiotherapy - Beyond the Abstract

68Ga-PSMA-11 PET/CT for Initial Staging of Unfavorable Intermediate-Risk and High-Risk Prostate Cancer Predicts Overall Survival: An IAEA Multicenter Study - Beyond the Abstract

Conference Coverage

SNMMI 2026: Safety and Efficacy of Rechallenge PSMA Radioligand Therapy in Post-Taxane mCRPC: An Early Single Center Experience

SNMMI 2026: Immunological Priming Improves Efficacy of 177Lu-PSMA-617 in mCRPC: A Retrospective Cohort Study

ASCO 2026: Phase I/II Study to Evaluate AZD9750, a Novel Androgen Receptor Proteolysis-Targeting Chimera, Alone and in Combination with Other Anticancer Agents in Patients with Metastatic Prostate Cancer (ANDROMEDA)

ASCO 2026: TIDAL: A Phase II Study of the DLL3-Directed T-Cell Engager Tarlatamab in DLL3-Positive Metastatic Prostate Cancer

ASCO 2026: Real-World Characteristics, HRR Mutation Testing, Treatment Patterns, and Outcomes of Patients with mCSPC in the US Community Oncology Setting

Articles

Editor Selected Abstracts and Commentaries

Prostate Cancer

Aglatimagene besadenovec (CAN-2409) with radiotherapy for patients with localised prostate cancer: a phase 3, multicentre, randomised, double-blind, placebo-controlled trial.

Perioperative Apalutamide in High-Risk Localized Prostate Cancer.

Ceralasertib Monotherapy in Patients with ATM-Altered Advanced Solid Tumors or Metastatic Castration-Resistant Prostate Cancer: Data from the Phase 2a PLANETTE Study.

Radionuclide Combination Strategies in Prostate Cancer: Insights from the AlphaBet Trial.

Phase I design for partially ordered groups with late-onset toxicity.

PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer.

Real-World Treatment Patterns for Patients with High-Risk Biochemically Recurrent Nonmetastatic Castration‑Sensitive Prostate Cancer.

Comparison of platinum and gold fiducial markers for prostate radiotherapy: a phantom study.

PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer

Perioperative Apalutamide in High-Risk Localized Prostate Cancer

Top advances of the year: Radiopharmaceutical therapy for prostate cancer.

Success and Limitations of PSMA RLT : The Nuclear Medicine View.

ISUP 2 prostate cancer with suspicion of extraprostatic extension on MRI: Prostatectomy results and oncologic outcomes.

Development and External Validation of a Machine Learning-Based Risk Classification Score for Prostate Cancer-Specific Cardiovascular Risk.

Prostate Cancer Treatment Patterns and Inequities Among Racial Groups in Brazil's Public Health System: Insights From a 16-Year Real-World Study.

Serum micronutrient levels in men with prostate carcinoma: An observational study at a tertiary care health facility.

Increasing and more consistent use of pre-biopsy MRI in prostate cancer diagnosis: insights from a population-based study in the Netherlands.

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer.

Trial protocol: RadTARGET, a multicenter phase II randomized controlled trial evaluating focal radiotherapy boost with de-intensification of dose to non-suspicious prostate in patients with intermediate- or high-risk prostate cancer.

Comparison of the Swedish and Finnish Centers in the European Randomized Study of Screening for Prostate Cancer (ERSPC).

Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness.

Comparative analysis of genitourinary toxicity following bladder outlet obstruction procedures in patients before versus after radiotherapy for localized prostate cancer: a retrospective cohort study using the TriNetX database.

PROQURE-I: a phase I study adding concurrent [177Lu]Lu-PSMA-617 to EBRT and ADT in curative intent treatment of N1 prostate cancer.

Emerging Therapeutic Strategies in Metastatic Hormone-Sensitive Prostate Cancer.

Analytical Validation of MyProstateScore 2.0-Active Surveillance: A Urinary-Based Clinical RT-PCR Prostate Cancer Assay.

Prioritising Data Quality Governance for AI in Prostate Cancer: A Methodological Proof-of-Concept Study Using Neural Networks for Risk Stratification.

Evaluating Oncological Outcomes in Patients with Multiple PiRADS Lesion Treated with Robot-Assisted Radical Prostatectomy for Prostate Cancer: Results from a Large Contemporary Cohort with Centralized MpMRI Evaluation in a High-Volume Center.

Genetic ancestry-concordant ceramide metabolism and response to androgen receptor pathway inhibition in metastatic castration-resistant prostate cancer.

Impact of frailty on perioperative and oncologic outcomes after robotic radical prostatectomy: a multicenter study with competing risk analysis.

Defining the combinatorial nature of gene modules in prostate cancer underlying lineage plasticity and metastasis.

Early-access Use of Radioligand Therapy in Prostate Cancer.

Adverse pathology and low tumor volume in biopsy Gleason 3 + 4 prostate cancer: Toward safe expansion of active surveillance and focal therapy.

Therapy Optimization in mHSPC: Insights from a Multidisciplinary Uro-Oncology Expert Panel.

CONNECT WITH US

Questions or Comments? Email us at editors@urotoday.com

Digital Science Press, LLC
2011 Phaethon Lane,
Reno, NV 89523

You are receiving this email because you have chosen to receive emails from UroToday.

Add us to your address book View this email as a web page Forward to a colleague Manage your subscriptions Unsubscribe

Copyright ©2026 Digital Science Press, LLC