Condition: Prostate Cancer Non-Metastatic, Castration-Resistant

Intervention:

• Drug: BAY1841788 (ODM-201)
• Drug: Placebo

Purpose: The purpose of this study is to assess the safety and efficacy of BAY1841788 (ODM-201) in patients with non-metastatic castration-resistant prostate cancer.

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02200614

Sponsor: Bayer

Primary Outcome Measures:

• Measure: Metastasis-Free Survival
• Time Frame: Up to 72 months
• Safety Issue:

Secondary Outcome Measures:

• Measure: Overall Survival
• Time Frame: Up to 72 months
• Safety Issue:
• Measure: Time to first symptomatic skeletal event (SSE)
• Time Frame: Up to 72 months
• Safety Issue:
• Measure: Time to initiation of first cytotoxic chemotherapy for prostate cancer
• Time Frame: Up to 72 months
• Safety Issue:
• Measure: Time to pain progression
• Time Frame: Up to 72 months
• Safety Issue:
• Measure: Safety and tolerability of ODM-201
• Time Frame: Up to 72 months
• Safety Issue:

Estimated Enrollment: 1500

Study Start Date: September 12, 2014

Phase: Phase 3

Eligibility:

• Age: minimum 18 Years maximum N/A
• Gender: Male

Inclusion Criteria:

• Histologically or cytologically confirmed adenocarcinoma of prostate without neuroendocrine differentiation or small cell features.
• Castration-resistant prostate cancer (CRPC) with castrate level of serum testosterone.
• Prostate-specific antigen doubling time of ≤ 10 months and PSA > 2ng/ml.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
• Blood counts at screening: haemoglobin ≥ 9.0 g/dl,absolute neutrophil count ≥ 1500/µl, platelet count ≥ 100,000/µl.
• Screening values of serum alanine aminotransferase (ALT) and/or aspartate transaminase (AST) ≤ 2.5 x upper limit of normal (ULN), total bilirubin ≤ 1.5 x ULN, creatinine ≤ 2.0 x ULN.
• Sexually active patients, unless surgically sterile, must agree to use condoms as an effective barrier method and refrain from sperm donation during the study treatment and for 3 months after the end of the study treatment.

Exclusion Criteria:

• History of metastatic disease at any time or presence of detectable metastases.
• Acute toxicities of prior treatments and procedures not resolved to grade ≤ 1 or baseline before randomisation.
• Prior treatment with: second generation androgen receptor (AR) inhibitors, other investigational AR inhibitors, or CYP17 enzyme inhibitor.
• Use of estrogens or 5-α reductase inhibitors or AR inhibitors.
• Prior chemotherapy or immunotherapy for prostate cancer.
• Use of systemic corticosteroid.
• Radiation therapy within 12 weeks before randomisation.
• Severe or uncontrolled concurrent disease, infection or co-morbidity.
• Treatment with bisphosphonate or denosumab within 12 weeks before randomisation.
• Known hypersensitivity to the study treatment or any of its ingredients.
• Major surgery within 28 days before randomisation.
• Any of the following within 6 months before randomisation: stroke, myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft; congestive heart failure New York Heart Association (NYHA) Class III or IV.
• Uncontrolled hypertension.
• Prior malignancy.
• Gastrointestinal disorder or procedure which expects to interfere significantly with absorption of study treatment.
• Active viral hepatitis, active human immunodeficiency virus (HIV) or chronic liver disease.
• Treatment with any investigational drug within 28 days before randomisation.
• Any condition that in the opinion of the investigator would impair the patients' ability to comply with the study procedures.

Contact:

• Bayer Clinical Trials Contact
• +49 30 300139003

Locations:

• Homewood Alabama 35209 United States
  Anchorage Alaska 99503 United States
  Tucson Arizona 85704 United States
  Fountain Valley California 92708 United States
  La Jolla California 92093 United States
  Laguna Hills California 92653 United States
  Los Angeles California 90048 United States
  Los Angeles California 90073-1003 United States
  Orange California 92868 United States
  San Diego California 92120 United States
  Whittier California 90603 United States
  Denver Colorado 80211 United States
  Denver Colorado 80220 United States
  Parker Colorado 80134 United States
  Boca Raton Florida 33486 United States
  Miami Gardens Florida 33169 United States
  Orlando Florida 32803 United States
  Port Saint Lucie Florida 34952 United States
  Coeur d'Alene Idaho 83814 United States
  Chicago Illinois 60612 United States
  Evanston Illinois 60201-1613 United States
  Springfield Illinois 62704 United States
  Greenwood Indiana 46143 United States
  Indianapolis Indiana 46202 United States
  Jeffersonville Indiana 47130 United States
  West Des Moines Iowa 50266 United States
  Wichita Kansas 67226 United States
  New Orleans Louisiana 70121 United States
  Annapolis Maryland 21401 United States
  Baltimore Maryland 21201 United States
  Baltimore Maryland 21204 United States
  Salisbury Maryland 21801 United States
  Boston Massachusetts 02114 United States
  Farmington Hills Michigan 48334 United States
  Grand Rapids Michigan 49546 United States
  Royal Oak Michigan 48073 United States
  Woodbury Minnesota 55125 United States
  Omaha Nebraska 68114 United States
  Omaha Nebraska 68130 United States
  Lebanon New Hampshire 03756-0001 United States
  Edison New Jersey 08837 United States
  Englewood New Jersey 07631 United States
  Lawrenceville New Jersey 08648 United States
  Voorhees New Jersey 08043 United States
  Bronx New York 10461 United States
  Bronx New York 10469 United States
  Brooklyn New York 11215 United States
  New York New York 10016 United States
  Syracuse New York 13210 United States
  Asheboro North Carolina 27203 United States
  Durham North Carolina 27705 United States
  Gastonia North Carolina 28054 United States
  Canton Ohio 44718 United States
  Cincinnati Ohio 45212-1979 United States
  Cleveland Ohio 44195 United States
  Gahanna Ohio 43230 United States
  Middleburg Heights Ohio 44130 United States
  Oklahoma City Oklahoma 73104 United States
  Bala-Cynwyd Pennsylvania 19004 United States
  Bryn Mawr Pennsylvania 19010 United States
  Warwick Rhode Island 02886 United States
  Charleston South Carolina 29407 United States
  Myrtle Beach South Carolina 29572 United States
  Nashville Tennessee 37209 United States
  Dallas Texas 75231 United States
  Houston Texas 77027 United States
  Houston Texas 77030 United States
  San Antonio Texas 78240 United States
  Falls Church Virginia 22031 United States
  Richmond Virginia 23235 United States
  Virginia Beach Virginia 23462 United States
  Wheeling West Virginia 26003 United States
  Buenos Aires Ciudad Auton. De Buenos Aires C1120AAT Argentina
  Rosario Santa Fe S2000KZE Argentina
  Santa Fé Santa Fe S3000FFV Argentina
  San Miguel de Tucumán Tucuman T4000GTB Argentina
  San Miguel de Tucumán Tucuman T4000HXU Argentina
  Córdoba 5000 Argentina
  Córdoba X5000HXL Argentina
  Córdoba X5016KEH Argentina
  La Rioja 5300 Argentina
  Randwick New South Wales 2031 Australia
  St Leonards New South Wales 2065 Australia
  Waratah New South Wales 2298 Australia
  Douglas Queensland 4814 Australia
  South Brisbane Queensland 4101 Australia
  Fitzroy Victoria 3065 Australia
  Richmond Victoria 3122 Australia
  
  Kurralta Park 5037 Australia
  
  Linz Oberösterreich 4020 Austria
  
  Wels Oberösterreich 4600 Austria
  
  Wien 1020 Austria
  
  Wien 1090 Austria
  
  Brest 223041 Belarus
  
  Lesnoy 223040 Belarus
  
  Minsk 220013 Belarus
  
  Minsk 220114 Belarus
  
  Minsk 223041 Belarus
  
  Bonheiden 2820 Belgium
  
  Kortrijk 8500 Belgium
  
  Leuven 3000 Belgium
  
  Libramont 6800 Belgium
  
  Liege 4000 Belgium
  
  Sint-truiden 3800 Belgium
  
  Wilrijk 2610 Belgium
  
  Salvador-Bahia Bahia 40050410 Brazil
  
  Fortaleza Ceará 60430-230 Brazil
  
  Goiânia Goiás 74605-180 Brazil
  
  Belo Horizonte Minas Gerais 30150-270 Brazil
  
  Belo Horizonte Minas Gerais 30150-320 Brazil
  
  Juiz de Fora Minas Gerais 36010-510 Brazil
  
  Uberlandia Minas Gerais 38408-150 Brazil
  
  Curitiba Parana 81520-060 Brazil
  
  Recife Pernambuco 50070-550 Brazil
  
  Passo Fundo Rio Grande Do Sul 99010-260 Brazil
  
  Porto Alegre Rio Grande Do Sul 90050 170 Brazil
  
  Porto Alegre Rio Grande Do Sul 90610-000 Brazil
  
  Porto Alegre Rio Grande Do Sul Brazil
  
  Itajaí Santa Catarina 88301-220 Brazil
  
  Barretos Sao Paulo 14784400 Brazil
  
  Jau Sao Paulo 17210-080 Brazil
  
  Ribeirao Preto - SP Sao Paulo 14048-900 Brazil
  
  Sorocaba Sao Paulo 18035-300 Brazil
  
  São Paulo Sao Paulo 01209-000 Brazil
  
  São Paulo Sao Paulo 01236-030 Brazil
  
  São Paulo Sao Paulo 01246-000 Brazil
  
  São Paulo Sao Paulo 03102 002 Brazil
  
  São Paulo Sao Paulo 04039-004 Brazil
  
  Rio de Janeiro 20551-030 Brazil
  
  Plovdiv 4000 Bulgaria
  
  Sofia 1606 Bulgaria
  
  Sofia 1680 Bulgaria
  
  Varna 9000 Bulgaria
  
  Calgary Alberta T2V 1P9 Canada
  
  Victoria British Columbia V8T 2C1 Canada
  
  Halifax Nova Scotia B3H 2Y9 Canada
  
  Barrie Ontario L4M 7G1 Canada
  
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  Medellín Antioquia Colombia
  
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  Bucaramanga Santander Colombia
  
  Hradec Kralove 500 05 Czechia
  
  Jablonec nad Nisou 466 60 Czechia
  
  Karlovy Vary 360 66 Czechia
  
  Kolin 280 00 Czechia
  
  Olomouc 775 20 Czechia
  
  Opava 746 01 Czechia
  
  Praha 10 10034 Czechia
  
  Praha 2 120 00 Czechia
  
  Praha 2 12808 Czechia
  
  Praha 5 150 06 Czechia
  
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  Tallinn 10138 Estonia
  
  Tallinn 13419 Estonia
  
  Tallinn 13912 Estonia
  
  Tartu 51014 Estonia
  
  HUS 00029 Finland
  
  KYS 70029 Finland
  
  Seinäjoki 60220 Finland
  
  Tampere Finland
  
  Turku FIN-20521 Finland
  
  Angers 49933 France
  
  Bayonne 64100 France
  
  Besancon 25030 France
  
  Bordeaux 33076 France
  
  CAEN cedex 05 14076 France
  
  Clermont Ferrand Cedex 1 63011 France
  
  Creteil 94010 France
  
  Dijon 21000 France
  
  La Roche Sur Yon Cedex 85025 France
  
  Limoges Cedex 87042 France
  
  Montpellier Cedex 34298 France
  
  Montpellier 34000 France
  
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  Nantes Cedex 44093 France
  
  Nice Cedex 2 06102 France
  
  Paris 75010 France
  
  Paris 75014 France
  
  Paris 75014 France
  
  Paris 75020 France
  
  Pierre Benite 69495 France
  
  Poitiers Cedex 86021 France
  
  Pontoise 95301 France
  
  Quimper 29000 France
  
  Reims 51056 France
  
  Rennes Cedex 35033 France
  
  Rouen Cedex 76031 France
  
  Saint Mande 94160 France
  
  Strasbourg 67000 France
  
  Suresnes 92151 France
  
  Tours 37044 France
  
  Villejuif Cedex 94805 France
  
  Emmendingen Baden-Württemberg 79312 Germany
  
  Heidelberg Baden-Württemberg 69115 Germany
  
  Kirchheim unter Teck Baden-Württemberg 73230 Germany
  
  Mühlacker Baden-Württemberg 75417 Germany
  
  Reutlingen Baden-Württemberg 72764 Germany
  
  Tübingen Baden-Württemberg 72076 Germany
  
  Waldshut-Tiengen Baden-Württemberg 79761 Germany
  
  Nürnberg Bayern 90489 Germany
  
  Planegg Bayern 82152 Germany
  
  Frankfurt Hessen 60590 Germany
  
  Marburg Hessen 35039 Germany
  
  Hagenow Mecklenburg-Vorpommern 19230 Germany
  
  Rostock Mecklenburg-Vorpommern 18107 Germany
  
  Hannover Niedersachsen 30625 Germany
  
  Herzberg Am Harz Niedersachsen 37412 Germany
  
  Holzminden Niedersachsen 37603 Germany
  
  Osnabrück Niedersachsen 49076 Germany
  
  Düsseldorf Nordrhein-Westfalen 40225 Germany
  
  Köln Nordrhein-Westfalen 50931 Germany
  
  Mülheim Nordrhein-Westfalen 45468 Germany
  
  Münster Nordrhein-Westfalen 48149 Germany
  
  Wuppertal Nordrhein-Westfalen 42103 Germany
  
  Mainz Rheinland-Pfalz 55131 Germany
  
  Homburg Saarland 66421 Germany
  
  Magdeburg Sachsen-Anhalt 39112 Germany
  
  Dresden Sachsen 01307 Germany
  
  Markkleeberg Sachsen 04416 Germany
  
  Berlin 10115 Germany
  
  Berlin 12200 Germany
  
  Hamburg 20246 Germany
  
  Hamburg 22081 Germany
  
  Tübingen 72076 Germany
  
  Abelokipi - Athens 115 26 Greece
  
  Athens 115 27 Greece
  
  Athens 11522 Greece
  
  Athens 11527 Greece
  
  Athens 11528 Greece
  
  Glyfada/Athens 16675 Greece
  
  Ioannina 45500 Greece
  
  Thessaloniki-Moudanion 57001 Greece
  
  Budapest 1085 Hungary
  
  Budapest 1145 Hungary
  
  Budapest 1204 Hungary
  
  Debrecen 4032 Hungary
  
  Gyor 9024 Hungary
  
  Nyiregyhaza 4400 Hungary
  
  Szeged 6725 Hungary
  
  Szekszard 7100 Hungary
  
  Szolnok 5004 Hungary
  
  Zalaegerszeg 8900 Hungary
  
  Beer Sheva 8410101 Israel
  
  Haifa 3339419 Israel
  
  Haifa 35152 Israel
  
  Jerusalem 9103102 Israel
  
  Nahariya 2210001 Israel
  
  Ramat Gan 5262000 Israel
  
  Tel Aviv 6423906 Israel
  
  Zefat 1311001 Israel
  
  Chieti Abruzzo 66100 Italy
  
  Catanzaro Calabria 88100 Italy
  
  Napoli Campania 80131 Italy
  
  Napoli Campania Italy
  
  Bologna Emilia-Romagna 40138 Italy
  
  Forlì-Cesena Emilia-Romagna 47014 Italy
  
  Modena Emilia-Romagna 41124 Italy
  
  Parma Emilia-Romagna 43126 Italy
  
  Roma Lazio 00144 Italy
  
  Roma Lazio 00189 Italy
  
  Como Lombardia Italy
  
  Milano Lombardia 20159 Italy
  
  Novara Piemonte 28100 Italy
  
  Torino Piemonte 10043 Italy
  
  Torino Piemonte 10060 Italy
  
  Lecce Puglia 73100 Italy
  
  Catania Sicilia 95123 Italy
  
  Messina Sicilia 98125 Italy
  
  Palermo Sicilia 90127 Italy
  
  Arezzo Toscana 52100 Italy
  
  Siena Toscana 53100 Italy
  
  Nagoya Aichi 466-8560 Japan
  
  Nagoya Aichi 466-8650 Japan
  
  Kashiwa Chiba 277-8577 Japan
  
  Iizuka Fukuoka 820-8505 Japan
  
  Kurume Fukuoka 839-0863 Japan
  
  Koriyama Fukushima 963-8052 Japan
  
  Maebashi Gunma 371-8511 Japan
  
  Otake Hiroshima 739-0696 Japan
  
  Sapporo Hokkaido 060-8543 Japan
  
  Kobe Hyogo 650-0047 Japan
  
  Higashiibaraki Ibaraki 311-3193 Japan
  
  Kahoku-gun Ishikawa 920-0293 Japan
  
  Kanazawa Ishikawa 920-8530 Japan
  
  Sagamihara Kanagawa 252-0375 Japan
  
  Yokohama Kanagawa 232-0024 Japan
  
  Yokosuka Kanagawa 238-8558 Japan
  
  Sendai Miyagi 980-8574 Japan
  
  Sendai Miyagi 981-8563 Japan
  
  Ueda Nagano 386-8610 Japan
  
  Kashihara Nara 634-8522 Japan
  
  Yufu Oita 879-5593 Japan
  
  Kurashiki Okayama 710-8602 Japan
  
  Higashiosaka Osaka 578-8588 Japan
  
  Osakasayama Osaka 589-8511 Japan
  
  Takatsuki Osaka 569-1192 Japan
  
  Wako Saitama 351-0102 Japan
  
  Hamamatsu Shizuoka 431-3192 Japan
  
  Sunto Shizuoka 411-8611 Japan
  Utsunomiya Tochigi 321-0974 Japan
  Bunkyo-ku Tokyo 113-8431 Japan
  Bunkyo-ku Tokyo 113-8603 Japan
  Itabashi-ku Tokyo 173-0015 Japan
  Minato-ku Tokyo 105-8471 Japan
  Mitaka Tokyo 181-8611 Japan
  Nakano-ku Tokyo 164-8541 Japan
  Shinjuku-ku Tokyo 160-8582 Japan
  
  Sumida-ku Tokyo 130-8587 Japan
  
  Ube Yamaguchi 755-8505 Japan
  
  Chiba 260-8717 Japan
  
  Fukui 910-8526 Japan
  
  Hiroshima 730-8518 Japan
  
  Kumamoto 861-8520 Japan
  
  Kyoto 602-8566 Japan
  
  Nagasaki 852-8501 Japan
  
  Nagasaki 852-8511 Japan
  
  Okayama 700-8558 Japan
  
  Osaka 541-8567 Japan
  
  Osaka 545-8586 Japan
  
  Osaka 558-8558 Japan
  
  Toyama 930-0194 Japan
  
  Donggu, Gwangju Gwang''yeogsi 501-757 Korea, Republic of
  
  Seoul Seoul Teugbyeolsi 135-720 Korea, Republic of
  
  Chungchungbuk-do 361-711 Korea, Republic of
  
  Daegu 700-701 Korea, Republic of
  
  Daegu 700-712 Korea, Republic of
  
  Incheon 405-760 Korea, Republic of
  
  Seoul 110-744 Korea, Republic of
  
  Seoul 120-752 Korea, Republic of
  
  Seoul 135-710 Korea, Republic of
  
  Seoul 137-701 Korea, Republic of
  
  Seoul 138-736 Korea, Republic of
  
  Daugavpils LV5401 Latvia
  
  Jelgava LV-3001 Latvia
  
  Leipaja LV-3401 Latvia
  
  Riga LV-1001 Latvia
  
  Riga LV-1002 Latvia
  
  Riga LV-1038 Latvia
  
  Kaunas LT-50009 Lithuania
  
  Klaipeda LT-92288 Lithuania
  
  Vilnius LT-08660 Lithuania
  
  Vilnius LT-08661 Lithuania
  
  La Victoria Arequipa Peru
  
  Lima 27 Peru
  
  Lima LIMA 11 Peru
  
  Lima LIMA 18 Peru
  
  Lima LIMA 27 Peru
  
  Elblag 82-300 Poland
  
  Gdansk 80-952 Poland
  
  Lodz 90-302 Poland
  
  Lodz 90-549 Poland
  
  Lublin 20-718 Poland
  
  Otwock Poland
  
  Rzeszow 35-922 Poland
  
  Siedlce 08-110 Poland
  
  Warszawa 02-005 Poland
  
  Warszawa 02-507 Poland
  
  Warszawa 02-616 Poland
  
  Warszawa 02-781 Poland
  
  Warszawa 04-125 Poland
  
  Wroclaw 50-556 Poland
  
  Wroclaw 54-144 Poland
  
  Santa Maria da Feira Porto 4520-211 Portugal
  
  Almada 2801-951 Portugal
  
  Braga 4710-243 Portugal
  
  Coimbra 3000-075 Portugal
  
  Guimaraes 4835-044 Portugal
  
  Lisboa 1093-023 Portugal
  
  Lisboa 1150-199 Portugal
  
  Lisboa 1349-019 Portugal
  
  Lisboa 1400-038 Portugal
  
  Lisboa 1500-650 Portugal
  
  Matosinhos 4464-513 Portugal
  
  Porto 4200-072 Portugal
  
  Porto 4200-319 Portugal
  
  Bucuresti 22328 Romania
  
  Bucuresti 41345 Romania
  
  Bucuresti 50659 Romania
  
  Bucuresti 75000 Romania
  
  Cluj-Napoca 400015 Romania
  
  Cluj-Napoca 400132 Romania
  
  Craiova 200385 Romania
  
  Craiova 200642 Romania
  
  Oradea 410159 Romania
  
  Ploiesti 100337 Romania
  
  Targu-Mures 540103 Romania
  
  Arkhangelsk 163045 Russian Federation
  
  Barnaul 656049 Russian Federation
  
  Chelyabinsk 454087 Russian Federation
  
  Ivanovo 153040 Russian Federation
  
  Kazan 420029 Russian Federation
  
  Krasnoyarsk 660022 Russian Federation
  
  Moscow 105425 Russian Federation
  
  Moscow 117997 Russian Federation
  
  Moscow 125284 Russian Federation
  
  Moscow 129301 Russian Federation
  
  Nizhny Novgorod 603001 Russian Federation
  
  Novosibirsk 630099 Russian Federation
  
  Obninsk 249036 Russian Federation
  
  Omsk 644013 Russian Federation
  
  Orenburg 460021 Russian Federation
  
  Pyatigorsk 357502 Russian Federation
  
  Rostov-on-Don 344022 Russian Federation
  
  Saratov 410012 Russian Federation
  
  St. Petersburg 191104 Russian Federation
  
  St. Petersburg 194017 Russian Federation
  
  St. Petersburg 194354 Russian Federation
  
  St. Petersburg 197022 Russian Federation
  
  St. Petersburg 197758 Russian Federation
  
  St. Petersburg 197758 Russian Federation
  
  Tyumen 625041 Russian Federation
  
  Ufa 450008 Russian Federation
  
  Volgograd 400138 Russian Federation
  
  Belgrade 11000 Serbia
  
  Belgrade 11000 Serbia
  
  Belgrade 11080 Serbia
  
  Kragujevac 34000 Serbia
  
  Nis 18000 Serbia
  
  Bratislava 833 05 Slovakia
  
  Bratislava 85101 Slovakia
  
  Martin 036 59 Slovakia
  
  Presov 080 81 Slovakia
  
  Skalica 90982 Slovakia
  
  Trencin 91101 Slovakia
  
  George Eastern Cape 3530 South Africa
  
  George Eastern Cape 6530 South Africa
  
  Port Elizabeth Eastern Cape 6045 South Africa
  
  Johannesburg Gauteng 2193 South Africa
  
  Pretoria Gauteng 0083 South Africa
  
  Durban Kwazulu-Natal 4126 South Africa
  
  Paarl Western Cape 7646 South Africa
  
  Rondebosch Western Cape 7700 South Africa
  
  Somerset West Western Cape 7130 South Africa
  
  Cape Town 7505 South Africa
  
  Cape Town 7925 South Africa
  
  Elche Alicante 03203 Spain
  
  Cádiz Andalucía 11009 Spain
  
  L'Hospitalet de Llobregat Barcelona 08907 Spain
  
  Sabadell Barcelona 08208 Spain
  
  Terrassa Barcelona 08221 Spain
  Jerez de la Frontera Cádiz 11407 Spain
  Manacor Illes Baleares 07500 Spain
  Palma de Mallorca Illes Baleares 07010 Spain
  Alcorcón Madrid 28922 Spain
  Fuenlabrada Madrid 28942 Spain
  Barakaldo Vizcaya 48903 Spain
  
  Barcelona 08025 Spain
  
  Barcelona 08035 Spain
  
  Barcelona 08036 Spain
  
  Bilbao 48013 Spain
  
  Córdoba 14004 Spain
  
  Granada 18012 Spain
  
  Granada 18014 Spain
  
  Lugo 27003 Spain
  
  Madrid 28007 Spain
  
  Madrid 28040 Spain
  
  Madrid 28041 Spain
  
  Madrid 28046 Spain
  
  Madrid 28050 Spain
  
  Málaga 29010 Spain
  
  Pamplona 31008 Spain
  
  Salamanca 37007 Spain
  
  Sevilla 41013 Spain
  
  Sevilla 41071 Spain
  
  Valencia 46009 Spain
  
  Valencia 46015 Spain
  
  Valencia 46026 Spain
  
  Valencia 46026 Spain
  
  Borås 501 82 Sweden
  
  Göteborg 413 45 Sweden
  
  Stockholm 171 76 Sweden
  
  Uppsala 751 85 Sweden
  
  Örebro 701 85 Sweden
  
  Kaohsiung City , Taiwan
  
  Kaoshiung 813 Taiwan
  
  Taichung 40705 Taiwan
  
  Taipei 10002 Taiwan
  
  Taoyuan 333 Taiwan
  
  Ankara 06560 Turkey
  
  Ankara 6100 Turkey
  
  Istanbul 34730 Turkey
  
  Izmir Turkey
  
  Manisa 45010 Turkey
  
  Sivas 58140 Turkey
  
  Chernivtsi 58002 Ukraine
  
  Dnipropetrovsk 49102 Ukraine
  
  Kharkiv 61037 Ukraine
  
  Kryvyi Rih 50048 Ukraine
  
  Kyiv 252053 Ukraine
  
  Kyiv 2660 Ukraine
  
  Uzhgorod 88014 Ukraine
  
  Zaporozhye 69600 Ukraine
  
  Reading Berkshire RG1 5AN United Kingdom
  
  Llanelli Carmarthenshire SA14 8QF United Kingdom
  
  Romford Essex RM7 0AG United Kingdom
  
  Stevenage Hertfordshire SG1 4AB United Kingdom
  
  Maidstone Kent ME16 9QQ United Kingdom
  
  Preston Lancashire PR2 4HT United Kingdom
  
  Bebington Merseyside CH63 4JY United Kingdom
  
  Scunthorpe North East Lincolnshire DN15 7BH United Kingdom
  
  Bath Somerset BA1 3NG United Kingdom
  
  Stoke-on-Trent Staffordshire ST4 6QG United Kingdom
  
  Dudley West Midlands DY1 2HQ United Kingdom
  
  Huddersfield West Yorkshire HD3 3EA United Kingdom
  
  Wakefield West Yorkshire WF1 4DG United Kingdom
  Worcester Worcestershire WR5 1DD United Kingdom
  Cardiff CF14 4XN United Kingdom>
  Dundee DD2 1UB United Kingdom
  Glasgow G12 0YN United Kingdom
  Kent DA2 8DA United Kingdom
  London SW17 0QT United Kingdom
  London SW3 6JJ United Kingdom
  Wrexham LL13 7TD United Kingdom

View trial on ClinicalTrials.gov