A Multinational, Randomised, Double-blind, Placebo-controlled, Phase III Efficacy and Safety Study of BAY1841788 (ODM-201) in Men With High-risk Non-metastatic Castration-resistant Prostate Cancer


Condition: Prostate Cancer Non-Metastatic, Castration-Resistant

Intervention:

  • Drug: BAY1841788 (ODM-201)
  • Drug: Placebo

Purpose: The purpose of this study is to assess the safety and efficacy of BAY1841788 (ODM-201) in patients with non-metastatic castration-resistant prostate cancer.

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02200614

Sponsor: Bayer

Primary Outcome Measures:

  • Measure: Metastasis-Free Survival
  • Time Frame: Up to 72 months
  • Safety Issue:

Secondary Outcome Measures:

  • Measure: Overall Survival
  • Time Frame: Up to 72 months
  • Safety Issue:
  • Measure: Time to first symptomatic skeletal event (SSE)
  • Time Frame: Up to 72 months
  • Safety Issue:
  • Measure: Time to initiation of first cytotoxic chemotherapy for prostate cancer
  • Time Frame: Up to 72 months
  • Safety Issue:
  • Measure: Time to pain progression
  • Time Frame: Up to 72 months
  • Safety Issue:
  • Measure: Safety and tolerability of ODM-201
  • Time Frame: Up to 72 months
  • Safety Issue:

Estimated Enrollment: 1500

Study Start Date: September 12, 2014

Phase: Phase 3

Eligibility:

  • Age: minimum 18 Years maximum N/A
  • Gender: Male

Inclusion Criteria:

  • Histologically or cytologically confirmed adenocarcinoma of prostate without neuroendocrine differentiation or small cell features.
  • Castration-resistant prostate cancer (CRPC) with castrate level of serum testosterone.
  • Prostate-specific antigen doubling time of ≤ 10 months and PSA > 2ng/ml.
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
  • Blood counts at screening: haemoglobin ≥ 9.0 g/dl,absolute neutrophil count ≥ 1500/µl, platelet count ≥ 100,000/µl.
  • Screening values of serum alanine aminotransferase (ALT) and/or aspartate transaminase (AST) ≤ 2.5 x upper limit of normal (ULN), total bilirubin ≤ 1.5 x ULN, creatinine ≤ 2.0 x ULN.
  • Sexually active patients, unless surgically sterile, must agree to use condoms as an effective barrier method and refrain from sperm donation during the study treatment and for 3 months after the end of the study treatment.

Exclusion Criteria:

  • History of metastatic disease at any time or presence of detectable metastases.
  • Acute toxicities of prior treatments and procedures not resolved to grade ≤ 1 or baseline before randomisation.
  • Prior treatment with: second generation androgen receptor (AR) inhibitors, other investigational AR inhibitors, or CYP17 enzyme inhibitor.
  • Use of estrogens or 5-α reductase inhibitors or AR inhibitors.
  • Prior chemotherapy or immunotherapy for prostate cancer.
  • Use of systemic corticosteroid.
  • Radiation therapy within 12 weeks before randomisation.
  • Severe or uncontrolled concurrent disease, infection or co-morbidity.
  • Treatment with bisphosphonate or denosumab within 12 weeks before randomisation.
  • Known hypersensitivity to the study treatment or any of its ingredients.
  • Major surgery within 28 days before randomisation.
  • Any of the following within 6 months before randomisation: stroke, myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft; congestive heart failure New York Heart Association (NYHA) Class III or IV.
  • Uncontrolled hypertension.
  • Prior malignancy.
  • Gastrointestinal disorder or procedure which expects to interfere significantly with absorption of study treatment.
  • Active viral hepatitis, active human immunodeficiency virus (HIV) or chronic liver disease.
  • Treatment with any investigational drug within 28 days before randomisation.
  • Any condition that in the opinion of the investigator would impair the patients' ability to comply with the study procedures.

Contact:

  • Bayer Clinical Trials Contact
  • +49 30 300139003

Locations:

  • Homewood Alabama 35209 United States
    Anchorage Alaska 99503 United States
    Tucson Arizona 85704 United States
    Fountain Valley California 92708 United States
    La Jolla California 92093 United States
    Laguna Hills California 92653 United States
    Los Angeles California 90048 United States
    Los Angeles California 90073-1003 United States
    Orange California 92868 United States
    San Diego California 92120 United States
    Whittier California 90603 United States
    Denver Colorado 80211 United States
    Denver Colorado 80220 United States
    Parker Colorado 80134 United States
    Boca Raton Florida 33486 United States
    Miami Gardens Florida 33169 United States
    Orlando Florida 32803 United States
    Port Saint Lucie Florida 34952 United States
    Coeur d'Alene Idaho 83814 United States
    Chicago Illinois 60612 United States
    Evanston Illinois 60201-1613 United States
    Springfield Illinois 62704 United States
    Greenwood Indiana 46143 United States
    Indianapolis Indiana 46202 United States
    Jeffersonville Indiana 47130 United States
    West Des Moines Iowa 50266 United States
    Wichita Kansas 67226 United States
    New Orleans Louisiana 70121 United States
    Annapolis Maryland 21401 United States
    Baltimore Maryland 21201 United States
    Baltimore Maryland 21204 United States
    Salisbury Maryland 21801 United States
    Boston Massachusetts 02114 United States
    Farmington Hills Michigan 48334 United States
    Grand Rapids Michigan 49546 United States
    Royal Oak Michigan 48073 United States
    Woodbury Minnesota 55125 United States
    Omaha Nebraska 68114 United States
    Omaha Nebraska 68130 United States
    Lebanon New Hampshire 03756-0001 United States
    Edison New Jersey 08837 United States
    Englewood New Jersey 07631 United States
    Lawrenceville New Jersey 08648 United States
    Voorhees New Jersey 08043 United States
    Bronx New York 10461 United States
    Bronx New York 10469 United States
    Brooklyn New York 11215 United States
    New York New York 10016 United States
    Syracuse New York 13210 United States
    Asheboro North Carolina 27203 United States
    Durham North Carolina 27705 United States
    Gastonia North Carolina 28054 United States
    Canton Ohio 44718 United States
    Cincinnati Ohio 45212-1979 United States
    Cleveland Ohio 44195 United States
    Gahanna Ohio 43230 United States
    Middleburg Heights Ohio 44130 United States
    Oklahoma City Oklahoma 73104 United States
    Bala-Cynwyd Pennsylvania 19004 United States
    Bryn Mawr Pennsylvania 19010 United States
    Warwick Rhode Island 02886 United States
    Charleston South Carolina 29407 United States
    Myrtle Beach South Carolina 29572 United States
    Nashville Tennessee 37209 United States
    Dallas Texas 75231 United States
    Houston Texas 77027 United States
    Houston Texas 77030 United States
    San Antonio Texas 78240 United States
    Falls Church Virginia 22031 United States
    Richmond Virginia 23235 United States
    Virginia Beach Virginia 23462 United States
    Wheeling West Virginia 26003 United States
    Buenos Aires Ciudad Auton. De Buenos Aires C1120AAT Argentina
    Rosario Santa Fe S2000KZE Argentina
    Santa Fé Santa Fe S3000FFV Argentina
    San Miguel de Tucumán Tucuman T4000GTB Argentina
    San Miguel de Tucumán Tucuman T4000HXU Argentina
    Córdoba 5000 Argentina
    Córdoba X5000HXL Argentina
    Córdoba X5016KEH Argentina
    La Rioja 5300 Argentina
    Randwick New South Wales 2031 Australia
    St Leonards New South Wales 2065 Australia
    Waratah New South Wales 2298 Australia
    Douglas Queensland 4814 Australia
    South Brisbane Queensland 4101 Australia
    Fitzroy Victoria 3065 Australia
    Richmond Victoria 3122 Australia

    Kurralta Park 5037 Australia

    Linz Oberösterreich 4020 Austria

    Wels Oberösterreich 4600 Austria

    Wien 1020 Austria

    Wien 1090 Austria

    Brest 223041 Belarus

    Lesnoy 223040 Belarus

    Minsk 220013 Belarus

    Minsk 220114 Belarus

    Minsk 223041 Belarus

    Bonheiden 2820 Belgium

    Kortrijk 8500 Belgium

    Leuven 3000 Belgium

    Libramont 6800 Belgium

    Liege 4000 Belgium

    Sint-truiden 3800 Belgium

    Wilrijk 2610 Belgium

    Salvador-Bahia Bahia 40050410 Brazil

    Fortaleza Ceará 60430-230 Brazil

    Goiânia Goiás 74605-180 Brazil

    Belo Horizonte Minas Gerais 30150-270 Brazil

    Belo Horizonte Minas Gerais 30150-320 Brazil

    Juiz de Fora Minas Gerais 36010-510 Brazil

    Uberlandia Minas Gerais 38408-150 Brazil

    Curitiba Parana 81520-060 Brazil

    Recife Pernambuco 50070-550 Brazil

    Passo Fundo Rio Grande Do Sul 99010-260 Brazil

    Porto Alegre Rio Grande Do Sul 90050 170 Brazil

    Porto Alegre Rio Grande Do Sul 90610-000 Brazil

    Porto Alegre Rio Grande Do Sul Brazil

    Itajaí Santa Catarina 88301-220 Brazil

    Barretos Sao Paulo 14784400 Brazil

    Jau Sao Paulo 17210-080 Brazil

    Ribeirao Preto - SP Sao Paulo 14048-900 Brazil

    Sorocaba Sao Paulo 18035-300 Brazil

    São Paulo Sao Paulo 01209-000 Brazil

    São Paulo Sao Paulo 01236-030 Brazil

    São Paulo Sao Paulo 01246-000 Brazil

    São Paulo Sao Paulo 03102 002 Brazil

    São Paulo Sao Paulo 04039-004 Brazil

    Rio de Janeiro 20551-030 Brazil

    Plovdiv 4000 Bulgaria

    Sofia 1606 Bulgaria

    Sofia 1680 Bulgaria

    Varna 9000 Bulgaria

    Calgary Alberta T2V 1P9 Canada

    Victoria British Columbia V8T 2C1 Canada

    Halifax Nova Scotia B3H 2Y9 Canada

    Barrie Ontario L4M 7G1 Canada

    Burlington Ontario L7N 3V2 Canada

    Hamilton Ontario L8N 4A6 Canada

    Kingston Ontario K7L 3J7 Canada

    London Ontario N6A 5W9 Canada

    Toronto Ontario M4N 3M5 Canada

    Toronto Ontario M5G 2M9 Canada

    Granby Quebec J2G 8Z9 Canada

    Pointe-Claire Quebec H9R 4S3 Canada

    Medellín Antioquia Colombia

    Montería Córdoba Colombia

    Bucaramanga Santander Colombia

    Hradec Kralove 500 05 Czechia

    Jablonec nad Nisou 466 60 Czechia

    Karlovy Vary 360 66 Czechia

    Kolin 280 00 Czechia

    Olomouc 775 20 Czechia

    Opava 746 01 Czechia

    Praha 10 10034 Czechia

    Praha 2 120 00 Czechia

    Praha 2 12808 Czechia

    Praha 5 150 06 Czechia

    Praha 6 160 00 Czechia

    Praha 8 180 81 Czechia

    Tallinn 10138 Estonia

    Tallinn 13419 Estonia

    Tallinn 13912 Estonia

    Tartu 51014 Estonia

    HUS 00029 Finland

    KYS 70029 Finland

    Seinäjoki 60220 Finland

    Tampere Finland

    Turku FIN-20521 Finland

    Angers 49933 France

    Bayonne 64100 France

    Besancon 25030 France

    Bordeaux 33076 France

    CAEN cedex 05 14076 France

    Clermont Ferrand Cedex 1 63011 France

    Creteil 94010 France

    Dijon 21000 France

    La Roche Sur Yon Cedex 85025 France

    Limoges Cedex 87042 France

    Montpellier Cedex 34298 France

    Montpellier 34000 France

    Montpellier 34070 France

    Nancy 54100 France

    Nantes Cedex 44093 France

    Nice Cedex 2 06102 France

    Paris 75010 France

    Paris 75014 France

    Paris 75014 France

    Paris 75020 France

    Pierre Benite 69495 France

    Poitiers Cedex 86021 France

    Pontoise 95301 France

    Quimper 29000 France

    Reims 51056 France

    Rennes Cedex 35033 France

    Rouen Cedex 76031 France

    Saint Mande 94160 France

    Strasbourg 67000 France

    Suresnes 92151 France

    Tours 37044 France

    Villejuif Cedex 94805 France

    Emmendingen Baden-Württemberg 79312 Germany

    Heidelberg Baden-Württemberg 69115 Germany

    Kirchheim unter Teck Baden-Württemberg 73230 Germany

    Mühlacker Baden-Württemberg 75417 Germany

    Reutlingen Baden-Württemberg 72764 Germany

    Tübingen Baden-Württemberg 72076 Germany

    Waldshut-Tiengen Baden-Württemberg 79761 Germany

    Nürnberg Bayern 90489 Germany

    Planegg Bayern 82152 Germany

    Frankfurt Hessen 60590 Germany

    Marburg Hessen 35039 Germany

    Hagenow Mecklenburg-Vorpommern 19230 Germany

    Rostock Mecklenburg-Vorpommern 18107 Germany

    Hannover Niedersachsen 30625 Germany

    Herzberg Am Harz Niedersachsen 37412 Germany

    Holzminden Niedersachsen 37603 Germany

    Osnabrück Niedersachsen 49076 Germany

    Düsseldorf Nordrhein-Westfalen 40225 Germany

    Köln Nordrhein-Westfalen 50931 Germany

    Mülheim Nordrhein-Westfalen 45468 Germany

    Münster Nordrhein-Westfalen 48149 Germany

    Wuppertal Nordrhein-Westfalen 42103 Germany

    Mainz Rheinland-Pfalz 55131 Germany

    Homburg Saarland 66421 Germany

    Magdeburg Sachsen-Anhalt 39112 Germany

    Dresden Sachsen 01307 Germany

    Markkleeberg Sachsen 04416 Germany

    Berlin 10115 Germany

    Berlin 12200 Germany

    Hamburg 20246 Germany

    Hamburg 22081 Germany

    Tübingen 72076 Germany

    Abelokipi - Athens 115 26 Greece

    Athens 115 27 Greece

    Athens 11522 Greece

    Athens 11527 Greece

    Athens 11528 Greece

    Glyfada/Athens 16675 Greece

    Ioannina 45500 Greece

    Thessaloniki-Moudanion 57001 Greece

    Budapest 1085 Hungary

    Budapest 1145 Hungary

    Budapest 1204 Hungary

    Debrecen 4032 Hungary

    Gyor 9024 Hungary

    Nyiregyhaza 4400 Hungary

    Szeged 6725 Hungary

    Szekszard 7100 Hungary

    Szolnok 5004 Hungary

    Zalaegerszeg 8900 Hungary

    Beer Sheva 8410101 Israel

    Haifa 3339419 Israel

    Haifa 35152 Israel

    Jerusalem 9103102 Israel

    Nahariya 2210001 Israel

    Ramat Gan 5262000 Israel

    Tel Aviv 6423906 Israel

    Zefat 1311001 Israel

    Chieti Abruzzo 66100 Italy

    Catanzaro Calabria 88100 Italy

    Napoli Campania 80131 Italy

    Napoli Campania Italy

    Bologna Emilia-Romagna 40138 Italy

    Forlì-Cesena Emilia-Romagna 47014 Italy

    Modena Emilia-Romagna 41124 Italy

    Parma Emilia-Romagna 43126 Italy

    Roma Lazio 00144 Italy

    Roma Lazio 00189 Italy

    Como Lombardia Italy

    Milano Lombardia 20159 Italy

    Novara Piemonte 28100 Italy

    Torino Piemonte 10043 Italy

    Torino Piemonte 10060 Italy

    Lecce Puglia 73100 Italy

    Catania Sicilia 95123 Italy

    Messina Sicilia 98125 Italy

    Palermo Sicilia 90127 Italy

    Arezzo Toscana 52100 Italy

    Siena Toscana 53100 Italy

    Nagoya Aichi 466-8560 Japan

    Nagoya Aichi 466-8650 Japan

    Kashiwa Chiba 277-8577 Japan

    Iizuka Fukuoka 820-8505 Japan

    Kurume Fukuoka 839-0863 Japan

    Koriyama Fukushima 963-8052 Japan

    Maebashi Gunma 371-8511 Japan

    Otake Hiroshima 739-0696 Japan

    Sapporo Hokkaido 060-8543 Japan

    Kobe Hyogo 650-0047 Japan

    Higashiibaraki Ibaraki 311-3193 Japan

    Kahoku-gun Ishikawa 920-0293 Japan

    Kanazawa Ishikawa 920-8530 Japan

    Sagamihara Kanagawa 252-0375 Japan

    Yokohama Kanagawa 232-0024 Japan

    Yokosuka Kanagawa 238-8558 Japan

    Sendai Miyagi 980-8574 Japan

    Sendai Miyagi 981-8563 Japan

    Ueda Nagano 386-8610 Japan

    Kashihara Nara 634-8522 Japan

    Yufu Oita 879-5593 Japan

    Kurashiki Okayama 710-8602 Japan

    Higashiosaka Osaka 578-8588 Japan

    Osakasayama Osaka 589-8511 Japan

    Takatsuki Osaka 569-1192 Japan

    Wako Saitama 351-0102 Japan

    Hamamatsu Shizuoka 431-3192 Japan

    Sunto Shizuoka 411-8611 Japan
    Utsunomiya Tochigi 321-0974 Japan
    Bunkyo-ku Tokyo 113-8431 Japan
    Bunkyo-ku Tokyo 113-8603 Japan
    Itabashi-ku Tokyo 173-0015 Japan
    Minato-ku Tokyo 105-8471 Japan
    Mitaka Tokyo 181-8611 Japan
    Nakano-ku Tokyo 164-8541 Japan
    Shinjuku-ku Tokyo 160-8582 Japan

    Sumida-ku Tokyo 130-8587 Japan

    Ube Yamaguchi 755-8505 Japan

    Chiba 260-8717 Japan

    Fukui 910-8526 Japan

    Hiroshima 730-8518 Japan

    Kumamoto 861-8520 Japan

    Kyoto 602-8566 Japan

    Nagasaki 852-8501 Japan

    Nagasaki 852-8511 Japan

    Okayama 700-8558 Japan

    Osaka 541-8567 Japan

    Osaka 545-8586 Japan

    Osaka 558-8558 Japan

    Toyama 930-0194 Japan

    Donggu, Gwangju Gwang''yeogsi 501-757 Korea, Republic of

    Seoul Seoul Teugbyeolsi 135-720 Korea, Republic of

    Chungchungbuk-do 361-711 Korea, Republic of

    Daegu 700-701 Korea, Republic of

    Daegu 700-712 Korea, Republic of

    Incheon 405-760 Korea, Republic of

    Seoul 110-744 Korea, Republic of

    Seoul 120-752 Korea, Republic of

    Seoul 135-710 Korea, Republic of

    Seoul 137-701 Korea, Republic of

    Seoul 138-736 Korea, Republic of

    Daugavpils LV5401 Latvia

    Jelgava LV-3001 Latvia

    Leipaja LV-3401 Latvia

    Riga LV-1001 Latvia

    Riga LV-1002 Latvia

    Riga LV-1038 Latvia

    Kaunas LT-50009 Lithuania

    Klaipeda LT-92288 Lithuania

    Vilnius LT-08660 Lithuania

    Vilnius LT-08661 Lithuania

    La Victoria Arequipa Peru

    Lima 27 Peru

    Lima LIMA 11 Peru

    Lima LIMA 18 Peru

    Lima LIMA 27 Peru

    Elblag 82-300 Poland

    Gdansk 80-952 Poland

    Lodz 90-302 Poland

    Lodz 90-549 Poland

    Lublin 20-718 Poland

    Otwock Poland

    Rzeszow 35-922 Poland

    Siedlce 08-110 Poland

    Warszawa 02-005 Poland

    Warszawa 02-507 Poland

    Warszawa 02-616 Poland

    Warszawa 02-781 Poland

    Warszawa 04-125 Poland

    Wroclaw 50-556 Poland

    Wroclaw 54-144 Poland

    Santa Maria da Feira Porto 4520-211 Portugal

    Almada 2801-951 Portugal

    Braga 4710-243 Portugal

    Coimbra 3000-075 Portugal

    Guimaraes 4835-044 Portugal

    Lisboa 1093-023 Portugal

    Lisboa 1150-199 Portugal

    Lisboa 1349-019 Portugal

    Lisboa 1400-038 Portugal

    Lisboa 1500-650 Portugal

    Matosinhos 4464-513 Portugal

    Porto 4200-072 Portugal

    Porto 4200-319 Portugal

    Bucuresti 22328 Romania

    Bucuresti 41345 Romania

    Bucuresti 50659 Romania

    Bucuresti 75000 Romania

    Cluj-Napoca 400015 Romania

    Cluj-Napoca 400132 Romania

    Craiova 200385 Romania

    Craiova 200642 Romania

    Oradea 410159 Romania

    Ploiesti 100337 Romania

    Targu-Mures 540103 Romania

    Arkhangelsk 163045 Russian Federation

    Barnaul 656049 Russian Federation

    Chelyabinsk 454087 Russian Federation

    Ivanovo 153040 Russian Federation

    Kazan 420029 Russian Federation

    Krasnoyarsk 660022 Russian Federation

    Moscow 105425 Russian Federation

    Moscow 117997 Russian Federation

    Moscow 125284 Russian Federation

    Moscow 129301 Russian Federation

    Nizhny Novgorod 603001 Russian Federation

    Novosibirsk 630099 Russian Federation

    Obninsk 249036 Russian Federation

    Omsk 644013 Russian Federation

    Orenburg 460021 Russian Federation

    Pyatigorsk 357502 Russian Federation

    Rostov-on-Don 344022 Russian Federation

    Saratov 410012 Russian Federation

    St. Petersburg 191104 Russian Federation

    St. Petersburg 194017 Russian Federation

    St. Petersburg 194354 Russian Federation

    St. Petersburg 197022 Russian Federation

    St. Petersburg 197758 Russian Federation

    St. Petersburg 197758 Russian Federation

    Tyumen 625041 Russian Federation

    Ufa 450008 Russian Federation

    Volgograd 400138 Russian Federation

    Belgrade 11000 Serbia

    Belgrade 11000 Serbia

    Belgrade 11080 Serbia

    Kragujevac 34000 Serbia

    Nis 18000 Serbia

    Bratislava 833 05 Slovakia

    Bratislava 85101 Slovakia

    Martin 036 59 Slovakia

    Presov 080 81 Slovakia

    Skalica 90982 Slovakia

    Trencin 91101 Slovakia

    George Eastern Cape 3530 South Africa

    George Eastern Cape 6530 South Africa

    Port Elizabeth Eastern Cape 6045 South Africa

    Johannesburg Gauteng 2193 South Africa

    Pretoria Gauteng 0083 South Africa

    Durban Kwazulu-Natal 4126 South Africa

    Paarl Western Cape 7646 South Africa

    Rondebosch Western Cape 7700 South Africa

    Somerset West Western Cape 7130 South Africa

    Cape Town 7505 South Africa

    Cape Town 7925 South Africa

    Elche Alicante 03203 Spain

    Cádiz Andalucía 11009 Spain

    L'Hospitalet de Llobregat Barcelona 08907 Spain

    Sabadell Barcelona 08208 Spain

    Terrassa Barcelona 08221 Spain
    Jerez de la Frontera Cádiz 11407 Spain
    Manacor Illes Baleares 07500 Spain
    Palma de Mallorca Illes Baleares 07010 Spain
    Alcorcón Madrid 28922 Spain
    Fuenlabrada Madrid 28942 Spain
    Barakaldo Vizcaya 48903 Spain

    Barcelona 08025 Spain

    Barcelona 08035 Spain

    Barcelona 08036 Spain

    Bilbao 48013 Spain

    Córdoba 14004 Spain

    Granada 18012 Spain

    Granada 18014 Spain

    Lugo 27003 Spain

    Madrid 28007 Spain

    Madrid 28040 Spain

    Madrid 28041 Spain

    Madrid 28046 Spain

    Madrid 28050 Spain

    Málaga 29010 Spain

    Pamplona 31008 Spain

    Salamanca 37007 Spain

    Sevilla 41013 Spain

    Sevilla 41071 Spain

    Valencia 46009 Spain

    Valencia 46015 Spain

    Valencia 46026 Spain

    Valencia 46026 Spain

    Borås 501 82 Sweden

    Göteborg 413 45 Sweden

    Stockholm 171 76 Sweden

    Uppsala 751 85 Sweden

    Örebro 701 85 Sweden

    Kaohsiung City , Taiwan

    Kaoshiung 813 Taiwan

    Taichung 40705 Taiwan

    Taipei 10002 Taiwan

    Taoyuan 333 Taiwan

    Ankara 06560 Turkey

    Ankara 6100 Turkey

    Istanbul 34730 Turkey

    Izmir Turkey

    Manisa 45010 Turkey

    Sivas 58140 Turkey

    Chernivtsi 58002 Ukraine

    Dnipropetrovsk 49102 Ukraine

    Kharkiv 61037 Ukraine

    Kryvyi Rih 50048 Ukraine

    Kyiv 252053 Ukraine

    Kyiv 2660 Ukraine

    Uzhgorod 88014 Ukraine

    Zaporozhye 69600 Ukraine

    Reading Berkshire RG1 5AN United Kingdom

    Llanelli Carmarthenshire SA14 8QF United Kingdom

    Romford Essex RM7 0AG United Kingdom

    Stevenage Hertfordshire SG1 4AB United Kingdom

    Maidstone Kent ME16 9QQ United Kingdom

    Preston Lancashire PR2 4HT United Kingdom

    Bebington Merseyside CH63 4JY United Kingdom

    Scunthorpe North East Lincolnshire DN15 7BH United Kingdom

    Bath Somerset BA1 3NG United Kingdom

    Stoke-on-Trent Staffordshire ST4 6QG United Kingdom

    Dudley West Midlands DY1 2HQ United Kingdom

    Huddersfield West Yorkshire HD3 3EA United Kingdom

    Wakefield West Yorkshire WF1 4DG United Kingdom
    Worcester Worcestershire WR5 1DD United Kingdom
    Cardiff CF14 4XN United Kingdom>
    Dundee DD2 1UB United Kingdom
    Glasgow G12 0YN United Kingdom
    Kent DA2 8DA United Kingdom
    London SW17 0QT United Kingdom
    London SW3 6JJ United Kingdom
    Wrexham LL13 7TD United Kingdom

View trial on ClinicalTrials.gov


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