An Open Label, Single Arm, Multicenter, Safety Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract


Condition: Urinary Tract Cancer

Intervention:

  • Drug: Atezolizumab

Purpose: This Phase IIIb, multicenter study will assess the safety of atezolizumab as second- to fourth-line treatment for participants with locally advanced or metastatic urothelial or non-urothelial cancer of the urinary tract in addition to evaluate the efficacy of atezolizumab and potential tumor biomarkers associated with atezolizumab.

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02928406

Sponsor: Hoffmann-La Roche

Primary Outcome Measures:

  • Measure: Percentage of Participants With Adverse Events
  • Time Frame: Baseline up to end of study (up to approximately 6 years)
  • Safety Issue:

Secondary Outcome Measures:

  • Measure: Overall Survival (OS)
  • Time Frame: Randomization until death from any cause (up to approximately 6 years)
  • Safety Issue:
  • Measure: Progression Free Survival (PFS) as per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)
  • Time Frame: Randomization up to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: PFS as per Modified Response Evaluation Criteria in Solid Tumors (Modified RECIST)
  • Time Frame: Randomization up to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: Percentage of Participants With Best Overall Response as Assessed by RECIST v1.1
  • Time Frame: Randomization up to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: Percentage of Participants With Best Overall Response as Assessed by Modified RECIST
  • Time Frame: Randomization up to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: Percentage of Participants With Disease Control as Assessed by RECIST v1.1
  • Time Frame: Randomization up to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: Percentage of Participants With Disease Control as Assessed by Modified RECIST
  • Time Frame: Randomization up to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: Duration of Response as Assessed by RECIST v1.1
  • Time Frame: Time from first occurrence of a documented response to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: Duration of Response as Assessed by Modified RECIST
  • Time Frame: Time from first occurrence of a documented response to disease progression or death from any cause, whichever occurs first (up to approximately 6 years)
  • Safety Issue:
  • Measure: Change From Baseline in Health-Related Quality of Life (HRQoL), as Assessed Using European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire Core 30 (QLQ-C30) Score
  • Time Frame: Baseline, Day 1 of Cycles 1, 2, 3 and thereafter every 9 weeks for 54 weeks from study treatment start; and then every 12 weeks until progression/study discontinuation (up to approximately 6 years) (Cycle length = 21 days)
  • Safety Issue:
  • Measure: Change from Baseline in European Quality of Life (EuroQoL) Group 5-Dimension 5-Level (EQ-5D-5L) Self Report Questionnaire Health Utility Score
  • Time Frame: Baseline, Day 1 of Cycles 1, 2, 3 and thereafter every 9 weeks for 54 weeks from study treatment start; and then every 12 weeks until progression/study discontinuation (up to approximately 6 years) (Cycle length = 21 days)
  • Safety Issue:

Estimated Enrollment: 1000

Study Start Date: November 30, 2016

Phase: Phase 3

Eligibility:

  • Age: minimum 18 Years maximum N/A
  • Gender: All

Inclusion Criteria:

  • Participants with histologically documented locally advanced (tumor [T] 4b, any node [N]; or any T, N 2-3) or metastatic (M1, Stage IV) urothelial or non-urothelial carcinoma of the urinary tract
  • Participants with measurable and/or non-measurable disease according to RECIST v1.1
  • Participants must have progressed during or following treatment with at least one prior (and not more than 3) treatments for inoperable, locally advanced or metastatic urothelial or non-urothelial carcinoma of the urinary tract
  • If available, a representative formalin-fixed paraffin-embedded (FFPE) tumor specimen block should be submitted
  • Eastern cooperative oncology group (ECOG) performance status 0, 1 or 2

Exclusion Criteria:

  • Treatment with more than three prior lines of systemic therapy for inoperable, locally advanced or metastatic urothelial or non-urothelial carcinoma of the urinary tract
  • Treatment with any other investigational agent or participation in another clinical trial with therapeutic intent within 4 weeks prior to study treatment initiation 1. Participants who were in another clinical trial with therapeutic intent within 4 weeks of study treatment initiation but were not on active drug in that prior trial are eligible 2. Participants who were in another clinical trial with therapeutic intent within 4 weeks of study treatment initiation but were in the follow-up phase of that prior trial and had stopped receiving active drug 4 or more weeks before study treatment initiation are eligible
  • Malignancies other than the one studied in this protocol within 5 years prior to Cycle 1, Day 1
  • Evidence of significant uncontrolled concomitant disease that could affect compliance with the protocol
  • Significant renal disorder indicating a need for renal transplant

Contact:

  • Reference Study ID Number: MO29983 www.roche.com/about_roche/roche_worldwide.htm
  • 888-662-6728 (U.S. and Canada)

Locations:

  • Inst. Alexander Fleming; Oncologia
  • Buenos Aires C1426ANZ Argentina
  • Hospital Aleman
  • Caba C1118AAT Argentina
  • Hospital Britanico de Buenos Aires
  • Ciudad Autonoma Buenos Aires C1284AEB Argentina
  • Canberra Hospital; Medical Oncology
  • Canberra Australian Capital Territory 2606 Australia
  • Prince of Wales Hospital; Oncology
  • Randwick New South Wales 2031 Australia
  • Northern Cancer Institute
  • St Leonards New South Wales 2065 Australia
  • Macquarie University Hospital
  • Sydney New South Wales 2109 Australia
  • Calvary Mater Newcastle; Medical Oncology
  • Waratah New South Wales 2298 Australia
  • Icon Cancer Foundation
  • South Brisbane Queensland 4101 Australia
  • Royal Adelaide Hospital
  • Adelaide South Australia 5000 Australia
  • Royal Hobart Hospital; Hematology/Oncology
  • Hobart Tasmania 7000 Australia
  • Box Hill Hospital
  • Box Hill Victoria 3128 Australia
  • Austin Hospital Olivia Newton John Cancer Centre
  • Heidelberg Victoria 3084 Australia
  • Medizinische Universität Innsbruck; Universitätsklinik für Urologie
  • Innsbruck 6020 Austria
  • Ordensklinikum Linz Elisabethinen; Abteilung für Urologie und Andrologie
  • Linz 4020 Austria
  • Landeskrankenhaus Salzburg; Universitätsklinik für Urologie und Andrologie der PMU
  • Salzburg 5020 Austria
  • Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie
  • Wien 1090 Austria
  • Medizinische Universität Wien; Universitätsklinik für Urologie
  • Wien 1090 Austria
  • UZ Brussel
  • Brussel 1090 Belgium
  • Cliniques Universitaires St-Luc
  • Bruxelles 1200 Belgium
  • UZ Leuven Gasthuisberg
  • Leuven 3000 Belgium
  • CHU Sart-Tilman
  • Liège 4000 Belgium
  • Pronutrir - suporte nutricional e quimioterapia ltda.
  • Fortaleza CE 60810-180 Brazil
  • Centro Integrado de Oncologia de Curitiba
  • Curitiba PR 80810-050 Brazil
  • Hospital Sao Lucas - PUCRS
  • Porto Alegre RS 90610-000 Brazil
  • Hospital de Cancer de Barretos
  • Barretos SP 14784-400 Brazil
  • Hospital Sirio Libanes; Centro de Oncologia - Unidade Brasilia
  • Brasilia SP 70200-730 Brazil
  • Hospital Alemao Oswaldo Cruz
  • Sao Paulo SP 01323-903 Brazil
  • Complex Oncology Center (COC)-Plovidiv
  • Plovdiv 4000 Bulgaria
  • University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
  • Sofia 1527 Bulgaria
  • SHATOD - Sofia
  • Sofia 1784 Bulgaria
  • Tom Baker Cancer Centre-Calgary
  • Calgary Alberta T2N 4N2 Canada
  • Cross Cancer Institute ; Dept of Medical Oncology
  • Edmonton Alberta T6G 1Z2 Canada
  • Royal Victoria Hospital
  • Barrie Ontario L4M 6M2 Canada
  • Queen Elizabeth II Health Sciences Centre
  • Halifax Ontario Canada
  • The Ottawa Hospital Cancer Center; General Campus
  • Ottawa Ontario K1H 1C4 Canada
  • Sun Yat-sen Memorial Hospital
  • Guangzhou 510000 China
  • Harbin Medical University Cancer Hospital
  • Harbin 150081 China
  • Jiangsu Cancer Hospital
  • Nanjing 210009 China
  • Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
  • Nanjing 210029 China
  • Fudan University Shanghai Cancer Center; Medical Oncology
  • Shanghai 200032 China
  • Clinica del Country
  • Bogota 11001 Colombia
  • Instituto Cancerologico de Nariño
  • Pasto Colombia
  • Clinical Hospital Centre Zagreb
  • Zagreb 10000 Croatia
  • Fakultni nemocnice u sv. Anny v Brne
  • Brno 656 91 Czechia
  • Fakultni nemocnice Kralovske Vinohrady
  • Praha 100 34 Czechia
  • Fakultni Thomayerova Nemocnice; Onkologicke Oddeleni
  • Praha 140 59 Czechia
  • Aalborg Universitetshospital, Klinik Kirurgi-Kræft, Onkologisk afd.
  • Aalborg 9000 Denmark
  • Aarhus Universitetshospital; Kræftafdelingen
  • Aarhus N 8200 Denmark
  • Herlev Hospital, Klinisk Forskningsenhed, Onkologisk Afdeling
  • Herlev 2730 Denmark
  • Rigshospitalet; Onkologisk Klinik
  • København Ø 2100 Denmark
  • Clinical Research Center (CRC), Faculty of Medicine, Alexandria University
  • Alexandria 21561 Egypt
  • Kasr Eieny Uni Hospital; Oncology (Nemrock)
  • Cairo 11562 Egypt
  • El Mokatam HIO Hospital
  • Cairo 11654 Egypt
  • Ain Shams University Hospital; Oncology
  • Cairo Egypt
  • East Tallinn Central Hospital; Clinic of Internal Medicine
  • Tallinn 11312 Estonia
  • North Estonia Medical Centre Foundation; Oncology Center
  • Tallinn 13419 Estonia
  • Universitätsklinikum "Carl Gustav Carus"; Klinik und Poliklinik für Urologie
  • Dresden 01307 Germany
  • Universitätsklinikum Erlangen; Medizinische Klinik 5; Hämatologie und Internistische Onkologie
  • Erlangen 91054 Germany
  • Universitätsmedizin Göttingen Georg-August-Universität; Klinik für Urologie
  • Göttingen 37075 Germany
  • Krankenhaus Martha-Maria Halle-Dölau, Klinik für Urologie
  • Halle (Saale) 06120 Germany
  • Medizinische Hochschule Hannover; Klinik für Urologie und Onkologische Urologie
  • Hannover 30625 Germany
  • Onkologische Schwerpunktpraxis
  • Heidelberg 69115 Germany
  • Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Urologie
  • Lübeck 23538 Germany
  • Universitätsklinikum Magdeburg A.ö.R., Klinik f. Urologie u. Kinderurologie
  • Magdeburg 39120 Germany
  • Kliniken Maria Hilf GmbH, Krankenhaus St. Franziskus
  • Mönchengladbach 41063 Germany
  • Klinikum rechts der Isar der TU München; Urologische Klinik und Poliklinik
  • München 81675 Germany
  • Universitätsklinikum Münster, Klinik für Urologie und Kinderurologie
  • Münster 48149 Germany
  • Universitätsklinikum Tübingen; Klinik für Urologie
  • Tübingen 72076 Germany
  • Universitätsklinikum Ulm; Klinik für Urologie
  • Ulm 89081 Germany
  • Alexandras General Hospital of Athens; Oncology Department
  • Athens 115 28 Greece
  • IASO General Hospital of Athens
  • Athens 155 62 Greece
  • Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept.
  • Kifisia 145 64 Greece
  • Metropolitan Hospital; 2Nd Oncology Clinic
  • Piraeus 185 47 Greece
  • Thermi Clinic; Oncology Clinic
  • Thermi Thessalonikis 570 01 Greece
  • Papageorgiou General Hospital; Medical Oncology
  • Thessaloniki 546 29 Greece
  • Euromedical General Clinic of Thessaloniki; Oncology Department
  • Thessaloniki 546 45 Greece
  • Honvédelmi Minisztérium Állami Egészségügyi Központ; Onkológiai Osztály; Oncology department
  • Budapest 1062 Hungary
  • Semmelwies University of Medicine; Urology Dept.
  • Budapest 1082 Hungary
  • Orszagos Onkologiai Intezet
  • Budapest 1122 Hungary
  • Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika
  • Szeged 6720 Hungary
  • Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház; Onkológiai Osztály
  • Szolnok 5004 Hungary
  • Rajiv Gandhi Cancer Inst.&Research Center; Medical Oncology
  • New Delhi Delhi 110085 India
  • HealthCare Global Cancer Centre; Medical Oncology
  • Ahmedabad Gujarat 380060 India
  • Tata Memorial Hospital; Dept of Medical Oncology
  • Mumbai Maharashtra 400012 India
  • Christian Medical College & Hospital; Medicine
  • Vellore Tamil NADU 632004 India
  • TATA Medical Centre; Medical Oncology
  • Kolkata WEST Bengal 700156 India
  • Artemis Health Institute
  • Gurgaon 122001 India
  • Max Super Speciality Hospital
  • New Delhi 110017 India
  • Cork University Hospital
  • Cork Ireland
  • Adelaide & Meath Hospital, Dublin, Incorporating the National Children's Hospital; Oncology Day Unit
  • Dublin 24 Ireland
  • Policlinico Ospedaliero Ss Annunziata; U.O. Di Clinica Oncologica
  • Chieti Abruzzo 66100 Italy
  • Azienda Ospedaliera Universitaria Federico II
  • Napoli Campania 80131 Italy
  • ISTITUTO NAZIONALE TUMORI IRCCS FONDAZIONE G. PASCALE; Dipartimento Uro-Ginecologico
  • Napoli Campania 80131 Italy
  • AZ.Osp S. Orsola - Malpighi-Reparto di Oncologia Medica
  • Bologna Emilia-Romagna 40138 Italy
  • IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
  • Meldola Emilia-Romagna 47014 Italy
  • A.O. Universitaria Policlinico Di Modena; Oncologia
  • Modena Emilia-Romagna 41100 Italy
  • Arcispedale Santa Maria Nuova; Oncologia
  • Reggio Emilia Emilia-Romagna 42100 Italy
  • A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia
  • Udine Friuli-Venezia Giulia 33100 Italy
  • Policlinico Universitario Campus Biomedico Di Roma; U.O.Oncologia Medica
  • Roma Lazio 00128 Italy
  • Azienda Ospedaliera San Camillo Forlanini; Oncologia Medica
  • Roma Lazio 00152 Italy
  • Policlinico Universitario "Agostino Gemelli"; U.O.C. Oncologia Medica
  • Roma Lazio 00168 Italy
  • IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A
  • Genova Liguria 16132 Italy
  • Asst Papa Giovanni XXIII; Oncologia Medica
  • Bergamo Lombardia 24128 Italy
  • ASST DI CREMONA; Dip. Medicina - S.C. Oncologia
  • Cremona Lombardia 26100 Italy
  • Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2
  • Milano Lombardia 20133 Italy
  • Istituto Europeo Di Oncologia
  • Milano Lombardia 20141 Italy
  • A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica
  • Orbassano Piemonte 10043 Italy
  • Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica
  • Bari Puglia 70124 Italy
  • IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
  • San Giovanni Rotondo Puglia 71013 Italy
  • A.O.U. Cagliari-P.O. Monserrato;U.O. Oncologia
  • Cagliari Sardegna 09100 Italy
  • Ospedale Cannizzaro, Oncologia
  • Catania Sicilia 95126 Italy
  • Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia
  • Arezzo Toscana 52100 Italy
  • Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2
  • Pisa Toscana 56100 Italy
  • Azienda Ospedaliera S. Maria - Terni; Oncologia
  • Terni Umbria 05100 Italy
  • IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima
  • Padova Veneto 35128 Italy
  • Azienda Ospedaliera di Verona-Policlinico G.B. Rossi; Oncologia Medica
  • Verona Veneto 37134 Italy
  • American University of Beirut - Medical Center
  • Beirut 1107 2020 Lebanon
  • Hotel Dieu de France; Oncology
  • Beirut 2063 1111 Lebanon
  • Hospital of Lithuanian University of Health Sciences Kaunas Clinics - Endocrinology clinic
  • Kaunas 50009 Lithuania
  • National Cancer Institute
  • Vilnius 08660 Lithuania
  • NKI/AvL
  • Amsterdam 1066 CX Netherlands
  • VU MEDISCH CENTRUM; Dept. of Medical Oncology
  • Amsterdam 1081 HV Netherlands
  • Academ Ziekenhuis Groningen; Medical Oncology
  • Groningen 9713 GZ Netherlands
  • Maastricht University Medical Centre; Medical Oncology
  • Maastricht 6229 HX Netherlands
  • Erasmus Mc - Daniel Den Hoed Kliniek; Interne Oncologie
  • Rotterdam 3015AA Netherlands
  • St. Antonius locatie Leidsche Rijn
  • Utrecht 3543 AZ Netherlands
  • Centrum Onkologii Ziemi LUBELSKIEJ im. Sw Jana z Dukli, I oddz. Chemioterapii
  • Lublin 20-090 Poland
  • Szpital Kliniczny Przemienienia Pańskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego
  • Poznan 60-570 Poland
  • Szpital Sw. Elzbiety - Mokotowskie Centrum Medyczne Sp. z o.o.
  • Warszawa 02-616 Poland
  • NZOZ Onko-Dent G. L. Slomian, Spolka Jawna
  • Żory 44-240 Poland
  • Hospital de Braga; Servico de Oncologia Medica X
  • Braga 4710-243 Portugal
  • HUC; Servico de Urologia e Transplantacao Renal
  • Coimbra 3000-075 Portugal
  • Hospital de Santa Maria; Servico de Oncologia Medica
  • Lisboa 1649-035 Portugal
  • IPO do Porto; Servico de Oncologia Medica
  • Porto 4200-072 Portugal
  • Oncopremium Team Srl
  • Baia Mare 430291 Romania
  • Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca; Spital de zi-Parter
  • Cluj-Napoca 400015 Romania
  • Centrul de Oncologie Sfantul Nectarie
  • Craiova 200347 Romania
  • Centrul de Radioterapie AMETHYST
  • Floresti 407280 Romania
  • Oncomed SRL; Oncologie
  • Timisoara 300239 Romania
  • Blokhin Cancer Research Center; Urological Dept
  • Moscow 115478 Russian Federation
  • P.A. Herzen Oncological Inst. ; Oncology
  • Moscow 125284 Russian Federation
  • King Faisal Specialist Hospital & Research Centre; Oncology
  • Riyadh 11211 Saudi Arabia
  • Narodny onkologicky ustav
  • Bratislava 833 10 Slovakia
  • Hospital Univ. Central de Asturias; Servicio de Oncologia
  • Oviedo Asturias 33011 Spain
  • Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
  • Badalona Barcelona 08916 Spain
  • Complejo Hospitalario de Althaia; Servicio de Oncologia
  • Manresa Barcelona 08243 Spain
  • Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
  • Sabadell Barcelona 08208 Spain
  • Hospital Universitario Reina Sofia; Servicio de Oncologia
  • Córdoba Cordoba 14004 Spain
  • Hospital Universitario Son Espases; Servicio de Oncologia
  • Palma De Mallorca Islas Baleares 07014 Spain
  • Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
  • Santiago de Compostela LA Coruña 15706 Spain
  • Hospital Universitario de Canarias;servicio de Oncologia
  • La Laguna Tenerife 38320 Spain
  • Hospital de Basurto; Servicio de Oncologia
  • Bilbao Vizcaya 48013 Spain
  • Hospital del Mar Barcelona
  • Barcelona 08003 Spain
  • Hospital Univ Vall d'Hebron; Servicio de Oncologia
  • Barcelona 08035 Spain
  • Hospital Clínic i Provincial; Servicio de Oncología
  • Barcelona 08036 Spain
  • Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
  • Barcelona 08041 Spain
  • Hospital Duran i Reynals; Oncologia
  • Barcelona 08907 Spain
  • Hospital San Pedro De Alcantara; Servicio de Oncologia
  • Caceres 10003 Spain
  • Hospital Universitari de Girona Dr. Josep Trueta; Servicio de Oncologia
  • Girona 17007 Spain
  • Hospital General Universitario de Guadalajara; Servicio de Oncologia
  • Guadalajara 19002 Spain
  • Hospital Lucus Augusti; Servicio de Oncologia
  • Lugo 27003 Spain
  • Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
  • Madrid 28007 Spain
  • Hospital Ramon y Cajal; Servicio de Oncologia
  • Madrid 28034 Spain
  • Hospital Clinico San Carlos; Servicio de Oncologia
  • Madrid 28040 Spain
  • Hospital Universitario 12 de Octubre; Servicio de Oncologia
  • Madrid 28041 Spain
  • Hospital Universitario La Paz; Servicio de Oncologia
  • Madrid 28046 Spain
  • HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia
  • Madrid 28050 Spain
  • Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
  • Malaga 29010 Spain
  • Hospital General Universitario J.M Morales Meseguer; Servicio de Oncologia
  • Murcia 30008 Spain
  • Hospital de Navarra; Servicio de Oncologia
  • Navarra 31008 Spain
  • Complejo Hospitalario de Orense; Servicio de Oncologia
  • Orense 32005 Spain
  • Hospital Universitario Virgen del Rocio; Servicio de Oncologia
  • Sevilla 41013 Spain
  • Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia
  • Toledo 45004 Spain
  • Hospital General Universitario de Valencia; Servicio de oncologia
  • Valencia 41014 Spain
  • Hospital Clínico Universitario de Valencia; Servicio de Oncología
  • Valencia 46010 Spain
  • Hospital La Fe
  • Valencia Spain
  • Hosp Clinico Univ Lozano Blesa; División De Oncología Médica
  • Zaragoza 50009 Spain
  • Universitaetsspital Basel; Onkologie
  • Basel 4031 Switzerland
  • Istituto Oncologico della Svizzera Italiana (IOSI)
  • Bellinzona 6500 Switzerland
  • Inselspital Bern; Universitätsklinik für medizinische Onkologie
  • Bern 3010 Switzerland
  • Kantonsspital Graubünden;Onkologie und Hämatologie
  • Chur 7000 Switzerland
  • HUG; Oncologie
  • Geneve 1211 Switzerland
  • Luzerner Kantonsspital; Medizinische Onkologie
  • Luzern 6004 Switzerland
  • Kantonsspital Winterthur; Medizinische Onkologie
  • Winterthur 8401 Switzerland
  • National Cheng Kung Uni Hospital; Dept of Hematology and Oncology
  • Tainan 704 Taiwan
  • Chang Gung Medical Foundation-Linkou, Urinary Oncology
  • Taoyuan 333 Taiwan
  • Ankara Uni School of Medicine; Medical Oncology
  • Ankara 06590 Turkey
  • Medeniyet University Goztepe Training and Research Hospital; Internal Diseases
  • Istanbul 34730 Turkey
  • Clatterbridge Cancer Centre
  • Bebington CH63 4JY United Kingdom
  • Royal Sussex County Hospital, CIRU Level 5
  • Brighton BN2 5BE United Kingdom
  • Velindre Cancer Centre
  • Cardiff CF14 2TL United Kingdom
  • Raigmore Hospital; Dept of Radiotherapy & Oncology
  • Inverness IV1 3UJ United Kingdom
  • Leicester Royal Infirmary NHS Trust
  • Leicester LE1 5WW United Kingdom
  • Barts and the London NHS Trust.
  • London EC1A 7BE United Kingdom
  • Freeman Hospital
  • Newcastle upon Tyne NE7 7DN United Kingdom
  • Royal Marsden NHS Foundation Trust
  • Sutton SM2 5PT United Kingdom

View trial on ClinicalTrials.gov


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