A Phase 3, Multicenter, Multinational, Randomized, Open-label, Parallel-arm Study Of Avelumab (MSB0010718C) Plus Best Supportive Care Versus Best Supportive Care Alone As A Maintenance Treatment In Patients With Locally Advanced Or Metastatic Urothelial Cancer Whose Disease Did Not Progress After Completion Of First-line Platinum-containing Chemotherapy


Condition: Urothelial Cancer

Intervention:

  • Biological: Avelumab
  • Other: Best Supportive Care

Purpose: The main purpose of this study is to compare maintenance treatment with avelumab plus best supportive care (BSC) with BSC alone, to determine if avelumab has an effect on survival in patients with locally advanced or metastatic urothelial cancer that did not worsen during or following completion of first-line chemotherapy.

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02603432

Sponsor: Pfizer

Primary Outcome Measures:

  • Measure: Overall Survival
  • Time Frame: Up to approximately 40 months
  • Safety Issue:

Secondary Outcome Measures:

  • Measure: Progression-Free Survival
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Objective Response
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Duration of Response
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Disease Control
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Cmax
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Ctrough
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Incidence of Anti-Drug Antibody
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Tumor Tissue Biomarkers
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: Functional Assessment of Cancer Therapy - Bladder Cancer
  • Time Frame: Up to approximately 40 months
  • Safety Issue:
  • Measure: EuroQoL EQ-5D
  • Time Frame: Up to approximately 40 months
  • Safety Issue:

Estimated Enrollment: 668

Study Start Date: April 28, 2016

Phase: Phase 3

Eligibility:

  • Age: minimum 18 Years maximum N/A
  • Gender: All

Inclusion Criteria:

  • Histologically confirmed, unresectable locally advanced or metastatic transitional cell carcinoma of the urothelium
  • Stage IV disease at the start of first-line chemotherapy
  • Measurable disease (per RECIST v1.1) prior to the start of first-line chemotherapy
  • Prior first-line chemotherapy must have consisted of at least 4 cycles and no more than 6 cycles of gemcitabine + cisplatin and/or gemcitabine + carboplatin
  • No evidence of progressive disease following completion of first-line chemotherapy (i.e., ongoing CR, PR, or SD per RECIST v1.1 guidelines )

Exclusion Criteria:

  • Prior adjuvant or neoadjuvant systemic therapy within 12 months of randomization
  • Prior immunotherapy with IL-2, IFN-α, or an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or CTLA 4 antibody (including ipilimumab), or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways
  • Persisting toxicity related to prior therapy (Grade >1 NCI CTCAE v4.0); however, alopecia, sensory neuropathy (Grade 2 or less), or other (Grade 2 or less) adverse events not constituting a safety risk based on the investigator's judgement are acceptable.
  • Patients with known symptomatic central nervous system (CNS) metastases requiring steroids
  • Diagnosis of any other malignancy within 5 years prior to randomization, except for adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the breast or of the cervix, low grade prostate cancer on surveillance without any plans for treatment intervention, or prostate cancer that has been adequately treated with prostatectomy or radiotherapy and currently with no evidence of disease or symptoms.

Contact:

  • Pfizer CT.gov Call Center
  • 1-800-718-1021

Locations:

  • Anschutz Cancer Center Pavilion Pharmacy
  • Aurora Colorado 80045 United States
  • University of Colorado Cancer Center
  • Aurora Colorado 80045 United States
  • University of Colorado Denver, CTO (CTRC)
  • Aurora Colorado 80045 United States
  • University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)
  • Aurora Colorado 80045 United States
  • University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)
  • Aurora Colorado 80045 United States
  • Smilow Cancer Hospital at Yale New Haven
  • New Haven Connecticut 06510 United States
  • Smilow Cancer Hospital at Yale-New Haven
  • New Haven Connecticut 06510 United States
  • Emory University Hospital
  • Atlanta Georgia 30322 United States
  • Investigational Drug Service- Emory University
  • Atlanta Georgia 30322 United States
  • The Emory Clinic
  • Atlanta Georgia 30322 United States
  • Winship Cancer Institute, Emory University
  • Atlanta Georgia 30322 United States
  • Massachusetts General Hospital
  • Boston Massachusetts 02114 United States
  • University of Minnesota Medical Center
  • Minneapolis Minnesota 55455 United States
  • University of Minnesota
  • Minneapolis Minnesota 55455 United States
  • Cleveland Clinic Foundation
  • Cleveland Ohio 44195 United States
  • Cleveland Clinic Taussing Cancer Center
  • Cleveland Ohio 44195 United States
  • Inova Schar Cancer Institute
  • Fairfax Virginia 22031 United States
  • Seattle Cancer Care Alliance
  • Seattle Washington 98109-1023 United States
  • Seattle Cancer Care Alliance
  • Seattle Washington 98109 United States
  • University of Washington Medical Center
  • Seattle Washington 98195 United States
  • Centro de Investigacion Pergamino S.A.
  • Pergamino Buenos Aires B2700CPM Argentina
  • Fundación CENIT para la Investigación en Neurociencias
  • Caba C1125ABD Argentina
  • GP Diagnostico SRL
  • La Rioja 5300 Argentina
  • Hospital Regional Dr. Enrique Vera Barros
  • La Rioja 5300 Argentina
  • Instituto del Diagnostico
  • La Rioja 5300 Argentina
  • Centro Oncologico Riojano Integral (Cori)
  • La Rioja F5300COE Argentina
  • Chris O'Brien Lifehouse Pharmacy
  • Camperdown New South Wales 2050 Australia
  • Chris O'Brien Lifehouse
  • Camperdown New South Wales 2050 Australia
  • Concord Hospital
  • Concord New South Wales 2139 Australia
  • Concord Repatriation General Hospital
  • Concord New South Wales 2139 Australia
  • Ramsay Pharmacy
  • Kogarah New South Wales 2217 Australia
  • St George Private Hospital
  • Kogarah New South Wales 2217 Australia
  • Epic Pharmacy
  • Lismore New South Wales 2480 Australia
  • Macquarie University Hospital Pharmacy
  • Macquarie University New South Wales 2109 Australia
  • Macquarie University
  • Macquarie University New South Wales 2109 Australia
  • Clinical Trials Pharmacy
  • St Leonards New South Wales 2065 Australia
  • Northern Sydney Cancer Centre
  • St Leonards New South Wales 2065 Australia
  • Royal North Shore Hospital
  • St Leonards New South Wales 2065 Australia
  • The Tweed Hospital
  • Tweed Heads New South Wales 2485 Australia
  • Icon Cancer Care Wesley
  • Auchenflower Queensland 4066 Australia
  • River City Pharmacy
  • Auchenflower Queensland 4066 Australia
  • Oncology Pharmacy
  • Birtinya Queensland 4575 Australia
  • Sunshine Coast University Hospital
  • Birtinya Queensland 4575 Australia
  • Icon Cancer Care Chermside
  • Chermside Queensland 4032 Australia
  • The Townsville Hospital
  • Douglas Queensland 4814 Australia
  • Slade Health
  • Geebung Queensland 4034 Australia
  • Icon Cancer Care South Brisbane
  • South Brisbane Queensland 4101 Australia
  • Icon Cancer Care
  • South Brisbane Queensland 4101 Australia
  • Icon Cancer Foundation
  • South Brisbane Queensland 4101 Australia
  • Icon Cancer Care Southport
  • Southport Queensland 4215 Australia
  • Flinders Medical Centre
  • Bedford Park South Australia 5042 Australia
  • SA Pharmacy, Level 3 Pharmacy
  • Bedford Park South Australia 5042 Australia
  • Adelaide Cancer Centre
  • Kurralta Park South Australia 5037 Australia
  • Ashford Cancer Centre Research
  • Kurralta park South Australia 5037 Australia
  • Cancer Care SA Pty Ltd
  • Kurralta Park South Australia 5037 Australia
  • Icon Cancer Care SA trading as Icon Pharmacy Adelaide
  • Kurralta Park South Australia 5037 Australia
  • Queen Elizabeth Hospital
  • Woodville South South Australia 5011 Australia
  • The Queen Elizabeth Hospital
  • Woodville South South Australia 5011 Australia
  • Lake Imaging
  • Ballarat Victoria 3350 Australia
  • Ballarat Oncology & Haematology Services
  • Ballarat Victoria 3355 Australia
  • Box Hill Hospital
  • Box Hill Victoria 3128 Australia
  • Eastern Health Clinical School
  • Box Hill Victoria 3128 Australia
  • Monash Medical Centre
  • Clayton Victoria 3168 Australia
  • Monash Cancer Centre
  • East Bentleigh Victoria 3165 Australia
  • Moorabbin Radiology
  • East Bentleigh Victoria 3165 Australia
  • Ballarat Day Procedure Centre
  • Wendouree Victoria 3355 Australia
  • Nova Pharmacy
  • Wendouree Victoria 3355 Australia
  • Slade Health
  • West Melbourne Victoria 3003 Australia
  • SKG Radiology
  • Murdoch Western Australia 6050 Australia
  • Fiona Stanley Hospital
  • Murdoch Western Australia 6150 Australia
  • St John of God Murdoch Hospital
  • Murdoch Western Australia 6150 Australia
  • AZ Klina - Apotheek
  • Brasschaat 2930 Belgium
  • AZ Klina
  • Brasschaat 2930 Belgium
  • Hôpital Erasme
  • Brussels 1070 Belgium
  • Hôpital Erasme
  • Bruxelles 1070 Belgium
  • UZ Gent
  • Gent 9000 Belgium
  • AZ Groeninge
  • Kortrijk 8500 Belgium
  • CHU de Liège
  • Liège 4000 Belgium
  • GZA Sint-Augustinus
  • Wilrijk 2610 Belgium
  • Hospital da Bahia
  • Salvador BA 41820-011 Brazil
  • CENOB Centro de Oncologia da Bahia S/S Ltda. / Oncovida
  • Salvador BA 41820-021 Brazil
  • Associação Educadora São Carlos - AESC / Hospital Giovanni Battista - HGB
  • Porto Alegre RIO Grande DO SUL 90470-340 Brazil
  • Instituto Nacional de Câncer - INCA
  • Rio de Janeiro RJ 20230-130 Brazil
  • Coordenação de Pesquisa Clínica do Instituto Nacional de Cancer - INCA
  • Rio de Janeiro RJ 20231-050 Brazil
  • Hospital Pró-Cardíaco
  • Rio de Janeiro RJ 22280-020 Brazil
  • Instituto COI de Pesquisa, Educação e Gestão/COI Clínicas Oncológicas Integradas SA - Farmácia
  • Rio de Janeiro RJ 22793-080 Brazil
  • Instituto COI de Pesquisa, Educação e Gestão/COI Clínicas Oncológicas Integradas SA
  • Rio de Janeiro RJ 22793-080 Brazil
  • Associação Hospital de Caridade Ijuí / Hospital de Caridade de Ijuí
  • Ijuí RS 98700-000 Brazil
  • Hospital Nossa Senhora da Conceição S/A
  • Porte Alegre RS 91350-200 Brazil
  • Associação Educadora São Carlos - AESC / Hospital Giovanni Battista - HGB - Farmácia Oncológica
  • Porto Alegre RS 90470-340 Brazil
  • Associação Educadora São Carlos - AESC / Hospital Giovanni Battista - HGB - Pesquisa Clínica
  • Porto Alegre RS 90470-340 Brazil
  • Uniao Brasileira de Educacao e Assistencia / Hospital Sao Lucas da PUCRS
  • Porto Alegre RS 90610-000 Brazil
  • Hospital Mãe de Deus
  • Porto Alegre RS 90880-481 Brazil
  • Hospital Nossa Senhora da Conceição S/A
  • Porto Alegre RS 91350-200 Brazil
  • Fundação FPio XII Barretos
  • Barretos SP 14784-400 Brazil
  • Fundação Pio XII Barretos
  • Barretos SP 14784-400 Brazil
  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
  • Sao Jose do Rio Preto SP 15090-000 Brazil
  • Fundacao Faculdade de Medicina / Instituto do Cancer do Estado de Sao Paulo - ICESP
  • Sao Paulo SP 01246-000 Brazil
  • Hospital Alemao Oswaldo Cruz
  • Sao Paulo SP 01323-903 Brazil
  • Hospital das Clinicas da Faculdade de Medicina da USP - HCFMUSP
  • Sao Paulo SP 05403-900 Brazil
  • Centro Integrado de Pesquisa Clinica - CIP
  • São José do Rio Preto SP 15090-000 Brazil
  • Sociedade Beneficente de Senhoras Hospital Sírio Libanês
  • São Paulo SP 01308-050 Brazil
  • Sociedade Beneficente de Senhoras Hospital Sírio Libanês
  • São Paulo SP 01308-060 Brazil
  • Hospital Israelita Albert Einstein - SP
  • São Paulo SP 05652-900 Brazil
  • William Osler Health System
  • Brampton Ontario L6R 3J7 Canada
  • Princess Margaret Cancer Centre
  • Toronto Ontario M5G 2M9 Canada
  • Hôpital Notre-Dame du CHUM, Oncology Pharmacy
  • Montreal Quebec H2L 4M1 Canada
  • Oncology Center, Hôpital Notre-Dame du Centre Hospitalier de l'Université de Montréal (CHUM)
  • Montreal Quebec H2L 4M1 Canada
  • Fakultni nemocnice u sv. Anny v Brne
  • Brno Ceska Republika 656 91 Czechia
  • Fakultni nemocnice Brno
  • Brno 625 00 Czechia
  • Fakultni nemocnice u sv. Anny v Brne
  • Brno 656 91 Czechia
  • Fakultni nemocnice u sv.Anny v Brne
  • Brno 656 91 Czechia
  • Nemocnice Horovice, NH Hospital a.s.
  • Horovice 268 31 Czechia
  • Nemocnice Horovice
  • Horovice 268 31 Czechia
  • Lekarna Multiscan Pharma s.r.o.
  • Pardubice 532 03 Czechia
  • Nemocnice Na Bulovce (IP Shipment)
  • Praha 8 180 81 Czechia
  • Nemocnice Na Bulovce
  • Praha 8 180 81 Czechia
  • Aalborg Universitetshospital
  • Aalborg 9000 Denmark
  • Aarhus Universitetshospital
  • Aarhus C 8000 Denmark
  • Aarhus Universitetshospital
  • Aarhus N 8200 Denmark
  • CT-Klinikken A/S
  • Aarhus N 8200 Denmark
  • Rigshospitalet, Onkologisk Klinik, afsnit 5073
  • Copenhagen OE 2100 Denmark
  • Herlev Hospital
  • Herlev 2730 Denmark
  • Rigshospitalet
  • København Ø 2100 Denmark
  • Odense Universitetshospital
  • Odense C 5000 Denmark
  • Odense Universitetshospital
  • Odense 5000 Denmark
  • Institut de cancérologie de l'Ouest - Site Paul Papin
  • Angers Cedex 02 49055 France
  • Institut de cancérologie de l'Ouest - Site Paul Papin
  • Angers 49100 France
  • Centre d'Oncologie et de Radiothérapie du Pays-Basque
  • Bayonne 64100 France
  • Clinique CAPIO Belharra
  • Bayonne 64100 France
  • Hôpital Jean Minjoz
  • BESANCON cedex 25030 France
  • CHU Besançon
  • Besançon 25030 France
  • Hôpital Henri Mondor
  • CRÉTEIL Cedex 94010 France
  • Hôpital Privé Toulon-Hyères - Clinique Sainte Marguerite
  • Hyères 83400 France
  • Clinique Victor Hugo
  • Le Mans 72015 France
  • Centre Oscar Lambret
  • Lille cedex 59020 France
  • Centre Oscar Lambret
  • Lille 59000 France
  • Centre Leon Berard
  • Lyon cedex 8 69373 France
  • Centre Léon Berard
  • LYON cedex 8 69373 France
  • Hopital La Conception
  • Marseille cedex 5 13285 France
  • Institut Paoli Calmettes
  • Marseille Cedex 9 13273 France
  • Institut Paoli Calmettes
  • Marseille 13009 France
  • Hopital de La Timone
  • Marseille 13385 cedex 05 France
  • Hopital de La Timone
  • Marseille 13385 France
  • CHU Nimes - Institut de Cancerologie du Gard
  • Nimes Cedex 9 30029 France
  • CHU Nimes
  • Nimes Cedex 9 30029 France
  • CHU Nimes - Hopital Caremeau
  • Nimes 30000 France
  • Groupe Hospitalier Pitié Salpêtrière
  • PARIS cedex 13 75651 France
  • Groupe Hospitalier Pitié Salpêtrière
  • Paris 75013 France
  • Centre Eugene Marquis
  • Rennes Cedex 35042 France
  • CHU de Rouen - Hôpital Charles Nicolle
  • Rouen 76031 France
  • Institut de cancérologie de l'Ouest - Centre René Gauducheau
  • Saint Herblain cedex 44805 France
  • Centre de Radiothérapie - Clinique Sainte Anne
  • Strasbourg 67000 France
  • Clinique Sainte Anne
  • Strasbourg 67000 France
  • Hopital FOCH
  • Suresnes 92150 France
  • Hopital Foch
  • Suresnes 92151 France
  • Institut Gustave Roussy
  • Villejuif cedex 94805 France
  • Institut Gustave Roussy
  • Villejuif 94805 France
  • IASO General Hospital
  • Athens Cholargos 15562 Greece
  • Sotiria General Chest Disease Hospital
  • Athens 11527 Greece
  • Alexandra General Hospital, Oncology Department
  • Athens 11528 Greece
  • University General Hospital of Patras, Division of Oncology
  • Patra 26504 Greece
  • EUROMEDICA General Clinic of Thessaloniki
  • Thessaloniki 546 45 Greece
  • Department of Clinical Oncology
  • Hong Kong Hong Kong
  • Peterfy Sandor utcai Korhaz-Rendelointezet es Baleseti Kozpont
  • Budapest 1076 Hungary
  • Péterfy Sándor utcai Kórház-Rendelőintézet és Baleseti Központ
  • Budapest 1076 Hungary
  • Kaposvári Egyetem Egészségügyi Centrum
  • Kaposvár 7400 Hungary
  • Somogy Megyei Kaposi Mór Oktató Kórház
  • Kaposvár 7400 Hungary
  • Dr RML Hospital & PGI MER
  • New Delhi Delhi 110001 India
  • CIMS Cancer, Care Institute of Medical Sciences, CIMS Hospital
  • Ahmedabad Gujarat 380060 India
  • Muljibhai Patel Urological Hospital
  • Nadiad Gujarat 387001 India
  • Meditrina Institute Of Medical Sciences
  • Nagpur Maharashtra 440010 India
  • Sahyadri Speciality Hospital
  • Pune Maharashtra 411004 India
  • Apollo Hospitals
  • Hyderabad Telangana 500096 India
  • Medica Superspecialty hospital
  • Kolkata WEST Bengal 700099 India
  • Rajiv Gandhi Cancer Institute and Research Centre
  • Delhi 110085 India
  • Hadassah University Hospital
  • Kiryat Hadassah Jerusalem 91120 Israel
  • The Chaim Sheba Medical Center
  • Tel-Hashomer Ramat - GAN 5265601 Israel
  • Assaf Harofe MC
  • Beer Yaakov 70300 Israel
  • Rambam Health Care Campus
  • Haifa 31096 Israel
  • Rabin Medical Center
  • Petach Tikva 49100 Israel
  • The Chaim Sheba Medical Center
  • Ramat - Gan 5265601 Israel
  • Farmacia Ospedaliera
  • Candiolo (torino) 10060 Italy
  • AOU Ospedali Riuniti di Ancona
  • Torrette Ancona 60126 Italy
  • Farmacia Oncologica
  • Meldola Forli-cesena 47014 Italy
  • Istituto Scientifico Romagnolo per lo studio e la cura dei Tumori
  • Meldola Forll-cesena 47014 Italy
  • Farmacia Studi Clinici
  • Rozzano Milan 20089 Italy
  • Istituto Clinico Humanitas
  • Rozzano Milan 20089 Italy
  • AUSL della Romagna - RAVENNA, Presidio Ospedaliero di Faenza
  • Faenza Ravenna 48018 Italy
  • Presidio Ospedaliero di Lugo
  • Lugo Ravenna 48022 Italy
  • Fondazione del Piemonte per l'Oncologia - IRCCS Candiolo
  • Candiolo Torino 10060 Italy
  • Presidio Ospedaliero San Donato
  • Arezzo Toscana 52100 Italy
  • Farmacia Ospedaliera
  • Arezzo 52100 Italy
  • Centro di Riferimento Oncologico - IRCCS
  • Aviano (PN) 33081 Italy
  • S.O.C. di Farmacia
  • Aviano (PN) 33081 Italy
  • Azienda Ospedaliero-Universitaria Policlinico S.Orsola Malpighi
  • Bologna 40138 Italy
  • U.O. Farmacia Clinica - IDS
  • Bologna 40138 Italy
  • IRCCS AOU San Martino - IST
  • Genova 16132 Italy
  • U.O.C. Farmacia
  • Genova 16132 Italy
  • Fondazione IRCCS Istituto Nazionale Dei Tumori
  • Milan 20133 Italy
  • SC Farmacia
  • Milan 20133 Italy
  • Instituto Europeo di Oncologia
  • Milan 20141 Italy
  • Servizio di Farmacia
  • Milan 20141 Italy
  • Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli"
  • Naples 80131 Italy
  • UOSC Farmacia
  • Naples 80131 Italy
  • Istituto Nazionale per lo Studio e la Cura dei Tumori, IRCCS Fondazione Giovanni Pascale
  • Napoli 80131 Italy
  • S.C. Farmacia Ospedaliera
  • Napoli 80131 Italy
  • Azienda Ospedaliero-Universitaria Maggiore della Carita
  • Novara 28100 Italy
  • S.C. Farmacia Ospedaliera
  • Novara 28100 Italy
  • A.O.U. Pisana Ospedale S. Chiara
  • Pisa 56126 Italy
  • U.O. Farmacia Ospedaliera
  • Pisa 56126 Italy
  • Presidio Ospedaliero di Ravenna
  • Ravenna 48121 Italy
  • Servizio Farmacia Ospedaliera - Farmacia Oncologia
  • Ravenna 48121 Italy
  • Azienda Ospedaliera San Camillo Forlanini_Oncologia Medica
  • Rome 00152 Italy
  • U.O.C. Farmacia
  • Rome 00152 Italy
  • Azienda Ospedaliera S. Maria di Terni
  • Terni 05100 Italy
  • S.C. Farmacia Interna
  • Terni 05100 Italy
  • Nagoya University Hospital
  • Nagoya Aichi 466-8560 Japan
  • Hirosaki University School of Medicine & Hospital
  • Hirosaki Aomori 036-8563 Japan
  • National Hospital Organization Shikoku Cancer Center
  • Matsuyama Ehime 791-0280 Japan
  • Gunma Prefectural Cancer Center
  • Ota Gunma 373-8550 Japan
  • National Hospital Organization hokkaido Cancer Center
  • Sapporo, Hokkaido 0030804 Japan
  • Hokkaido University Hospital
  • Sapporo Hokkaido 060-8648 Japan
  • Kobe City Medical Center General Hospital
  • Kobe-city Hyogo 650-0047 Japan
  • Tsukuba Medical Center Hospital
  • Tsukuba Ibaraki 305-8558 Japan
  • Iwate Medical University Hospital
  • Morioka Iwate 020-8505 Japan
  • National Hospital Organization Sagamihara National Hospital
  • Sagamihara Kanagawa 252-0392 Japan
  • Kanagawa Cancer Center
  • Yokohama Kanagawa 241-8515 Japan
  • Kindai University Hospital
  • Osakasayama Osaka 589-8511 Japan
  • Saitama Medical University International Medical Center
  • Hidaka Saitama 350-1298 Japan
  • Dokkyo Medical University Saitama Medical Center
  • Koshigaya Saitama 343-8555 Japan
  • Hamamatsu University School of Medicine, University Hospital
  • Hamamatsu Shizuoka 431-3192 Japan
  • Nihon University Itabashi Hospital
  • Itabashi-ku Tokyo 173-8610 Japan
  • Japanese Foundation For Cancer Research Cancer Institute Hospital
  • Koto-ku Tokyo 135-8550 Japan
  • Keio University Hospital
  • Shinjuku-Ku Tokyo 160-8582 Japan
  • Yamaguchi University Hospital
  • Ube Yamaguchi 755-8505 Japan
  • Chiba Cancer Center
  • Chiba 260-8717 Japan
  • National Hospital Organization Kyushu Cancer Center
  • Fukuoka 811-1395 Japan
  • Kyushu University Hospital
  • Fukuoka 812-8582 Japan
  • Hiroshima City Hiroshima Citizens Hospital
  • Hiroshima 730-8518 Japan
  • Kagoshima University Hospital
  • Kagoshima 890-8520 Japan
  • National Hospital Organization Kumamoto Medical Center
  • Kumamoto 860-0008 Japan
  • University Hospital, Kyoto Prefectural University of Medicine
  • Kyoto 602-8566 Japan
  • Niigata University Medical & Dental Hospital
  • Niigata 951-8520 Japan
  • Osaka City University Hospital
  • Osaka 545-8586 Japan
  • Tokushima University Hospital
  • Tokushima 770-8503 Japan
  • Yamagata University Hospital
  • Yamagata 990-9585 Japan
  • National Cancer Center - Clinical Trial Pharmacy
  • Goyang-si Gyeonggi-do 10408 Korea, Republic of
  • National Cancer Center Urology center for Prostate Cancer
  • Goyang-si Gyeonggi-do 10408 Korea, Republic of
  • Seoul National University Bundang Hospital, Clinical Pharmacy
  • Seongnam-si Gyeonggido 13620 Korea, Republic of
  • Seoul National University Bundang Hospital
  • Seongnam-si Gyeonggido 13620 Korea, Republic of
  • Chungnam National University Hospital, Clinical Pharmacy
  • Daejeon 35015 Korea, Republic of
  • Chungnam National University Hospital
  • Daejeon 35015 Korea, Republic of
  • Severance Hospital Yonsei University Health System
  • Seoul 03722 Korea, Republic of
  • Asan Medical Center - Clinical Trial Pharmacy
  • Seoul 05505 Korea, Republic of
  • Asan Medical Center
  • Seoul 05505 Korea, Republic of
  • Samsung Medical Center Clinical Trial Pharmacy
  • Seoul 06351 Korea, Republic of
  • Samsung Medical Center
  • Seoul 06351 Korea, Republic of
  • Instituto Nacional de Cancerologia
  • Mexico Ciudad DE Mexico 14080 Mexico
  • Phylasis Clinicas Research S. de R.L. de C.V.
  • Cuautitlan Izcalli Estado DE Mexico 54769 Mexico
  • Centro de Investigación Clínica de Leon S.C.
  • Leon Guanajuato 37520 Mexico
  • Hospital Médica Campestre (Administradora Hospitalaria S.A de C.V.)
  • León Guanajuato 37180 Mexico
  • Rijnstate Arnhem
  • Arnhem 6815 AD Netherlands
  • Ziekenhuis Rijnstate
  • Arnhem 6815 AD Netherlands
  • St Apotheek der Haarlemse Ziekenhuizen
  • Haarlem 2035 RC Netherlands
  • Spaarne Gasthuis
  • Hoofddorp 2134 TM Netherlands
  • Maastricht University Medical Center
  • Maastricht 6229 HX Netherlands
  • Radboud University Medical Center
  • Nijmegen 6525 GA Netherlands
  • Radboudumc
  • Nijmegen 6525 GA Netherlands
  • Auckland City Hospital Pharmacy
  • Grafton Auckland 1023 New Zealand
  • Auckland City Hospital
  • Grafton Auckland 1142 New Zealand
  • Christchurch Hospital
  • Christchurch 8140 New Zealand
  • Waikato Hospital
  • Hamilton 3240 New Zealand
  • Akershus universitetssykehus HF
  • Lorenskog 1478 Norway
  • Akershus University Hospital
  • Lorenskog 1478 Norway
  • Sykehusapoteket Lorenskog
  • Nordbyhagen 1474 Norway
  • Avdeling for radiologi
  • Stavanger 4011 Norway
  • Sjukehusapoteket i Stavanger
  • Stavanger 4011 Norway
  • Stavanger University Hospital
  • Stavanger 4011 Norway
  • Centralny Szpital Kliniczny MSWiA
  • Warszawa Masovian 02-507 Poland
  • Centrum Onkologii Ziemi Lubelskiej im. Sw. Jana z Dukli
  • Lublin 20-090 Poland
  • Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE
  • Coimbra 3000-075 Portugal
  • IMACENTRO - Clínica de Imagiologia Médica do Centro, SA
  • Coimbra 3020-479 Portugal
  • Centro Hospitalar de Lisboa Central, E.P.E. - Hospital de Santo António dos Capuchos
  • Lisboa 1169-050 Portugal
  • Hospital CUF Descobertas, SA
  • Lisboa 1998-018 Portugal
  • Dr. Campos Costa - Consultório de Tomografia Computorizada, S.A.
  • Porto 4050-075 Portugal
  • Dr. Campos Costa - Consultório de Tomografia Computorizada, S.A.
  • Porto 4050-075 Portugal
  • Centro Hospitalar do Porto, EPE - Hospital Geral de Santo António
  • Porto 4099-001 Portugal
  • Instituto Português de Oncologia do Porto Francisco Gentil, EPE
  • Porto 4200-072 Portugal
  • Centro Hospitalar de São João, EPE
  • Porto 4200-319 Portugal
  • "Sfantul Nectarie" Oncology Center
  • Craiova 200347 Romania
  • Republican Clinical Oncology Disp. of the MoH of Bashk. Rep.
  • Ufa Bashkortostan Republic 450054 Russian Federation
  • Private Medical Institution "Evromedservice"
  • Pushkin Saint Petersburg 196603 Russian Federation
  • University Clinic of Headaches, LLC
  • Moscow 109028 Russian Federation
  • University Clinic of Headaches, LLC
  • Moscow 121467 Russian Federation
  • MedScan RF clinic
  • Moscow 125565 Russian Federation
  • Research Institute of emergency n.a. Sklifosovskiy
  • Moscow 129090 Russian Federation
  • BHI of Omsk region "Clinical oncological dispensary"
  • Omsk 644013 Russian Federation
  • FGBIH "Clinical Hospital #122 n.a. L.G. Sokolov of Federal Medico-biological agency"
  • St. Petersburg 194291 Russian Federation
  • Non-State Healthcare Institution "Railway Clinical Hospital JSC RZhD"
  • St. Petersburg 195271 Russian Federation
  • First St. Petersburg State Medical University n.a. acad. I.P.Pavlov
  • St. Petersburg 197022 Russian Federation
  • FSBEI HE "First St. Petersburg State Medical University n.a. academician I.P Pavlov" MoH RF
  • St. Petersburg 197022 Russian Federation
  • FSBEI HE "First St. Petersburg State Medical University n.a. academician I.P Pavlov"
  • St. Petersburg 197022 Russian Federation
  • "Ramsay Diagnostics Rus", LLC
  • St. Petersburg 197046 Russian Federation
  • FSBI "Russian Scientific Center For Radiology and Surgical Technologies n.a. Academician A.M. Granov
  • St. Petersburg 197758 Russian Federation
  • Hospital Orkli, LLC
  • St. Petersburg 199178 Russian Federation
  • Mart, Llc
  • St. Petersburg 199178 Russian Federation
  • Clinicodiagnostic center "MedExpert", LLC (CT)
  • Yaroslavl 150014 Russian Federation
  • SHI YR "Regional Clinical Oncology Hospital"
  • Yaroslavl 150054 Russian Federation
  • Institute for Oncology and Radiology of Serbia
  • Belgrade 11000 Serbia
  • Clinical Centre Nis, Clinic of Oncology
  • Nis 18000 Serbia
  • C.H. Univ. Santiago de Compostela
  • Santiago de Compostela A Coruña 15706 Spain
  • Complejo Hospitalario Universitario de Santiago
  • Santiago de Compostela A Coruña 15706 Spain
  • Hospital Comarcal General de Elda de Virgen de la Salud
  • Elda Alicante 03600 Spain
  • Hospital Universitario San Juan de Alicante
  • Sant Joan d'Alacant Alicante 03550 Spain
  • Hospital Universitario Central de Asturias
  • Oviedo Asturias 33011 Spain
  • Hospital Universitario Germans Trias i Pujol
  • Badalona Barcelona 08916 Spain
  • Institut Catalá d'Oncología - Hospital Duran i Reynals
  • l´Hospitalet de LLobregat Barcelona 08908 Spain
  • Institut Catalá d'Oncología
  • L´Hospitalet de Llobregat Barcelona 08908 Spain
  • Althaia. Xarxa Assistencial Universitaria de Manresa
  • Manresa Barcelona 08243 Spain
  • Corporacio Sanitaria Parc Tauli
  • Sabadell Barcelona 08208 Spain
  • Hospital Vithas Internacional Medimar
  • Alicante Comunidad Valenciana 03016 Spain
  • Hospital General Universitario de Elche
  • Elche Comunidad Valenciana 03203 Spain
  • Hospital Clinico Universitario de Valencia
  • Valencia Comunidad Valenciana 46010 Spain
  • C.H. Universitario de Vigo- Hospital Meixoeiro
  • Vigo Galicia 36200 Spain
  • C. H. Universitario de Vigo- Hospital Álvaro Cunqueiro
  • Vigo Galicia 36312 Spain
  • C. H. Universitario de Vigo-Hospital Alvaro Cunqueiro
  • Vigo Galicia 36312 Spain
  • Hospital Universitario Infanta Sofia
  • San Sebastian de los Reyes Madrid 28702 Spain
  • Hospital Universitario Infanta Sofia
  • San Sebastián de los Reyes Madrid 28702 Spain
  • Clinica Universidad de Navarra
  • Pamplona Navarra 31008 Spain
  • Complejo Hospitalario de Navarra
  • Pamplona Navarra 31008 Spain
  • Hospital HM Modelo
  • A Coruña 15011 Spain
  • Hospital Infanta Cristina
  • Badajoz 06080 Spain
  • Hospital del Mar
  • Barcelona 08003 Spain
  • Hospital Quiron of Barcelona
  • Barcelona 08023 Spain
  • Hospital Quirón de Barcelona
  • Barcelona 08023 Spain
  • Institut de Diagnòstic per la Imatge
  • Barcelona 08023 Spain
  • Hospital de La Santa Creu i Sant pau_Oncology department
  • Barcelona 08025 Spain
  • Hospital de La Santa Creu i Sant Pau
  • Barcelona 08025 Spain
  • CETIR Grup Medic
  • Barcelona 08029 Spain
  • Cetir, Centre Mèdic, S.L
  • Barcelona 08029 Spain
  • Hospital Universitario Vall d'Hebron
  • Barcelona 08035 Spain
  • Hospital Clinic de Barcelona
  • Barcelona 08036 Spain
  • Laboratorio Dr. F. Echevarne Analisis, S.A
  • Barcelona 08037 Spain
  • Hospital Provincial
  • Cordoba 14004 Spain
  • Hospital Universitario Reina Sofía
  • Cordoba 14004 Spain
  • Hospital Universitari de Girona Dr Josep Trueta. Institut Catala d'Oncologia.
  • Gerona 17007 Spain
  • Hospital Universitari de Girona Dr Josep Trueta.
  • Gerona 17007 Spain
  • Hospital Universitario Lucus Augusti
  • Lugo 27003 Spain
  • Fundacion Maria Rafols para la investigacion del Diagnostico de la imagen
  • Madrid 28006 Spain
  • Gabinete Radiologico Doctor Pita
  • Madrid 28006 Spain
  • Hospital General Universitario Gregorio Marañon
  • Madrid 28007 Spain
  • Hospital Universitario Infanta Leonor
  • Madrid 28031 Spain
  • Hospital Ruber Internacional
  • Madrid 28034 Spain
  • Hospital Ruber International
  • Madrid 28034 Spain
  • Hospital Universitario Ramon y Cajal_Oncology department
  • Madrid 28034 Spain
  • Hospital Universitario Ramon y Cajal
  • Madrid 28034 Spain
  • Hospital Clinico San Carlos
  • Madrid 28040 Spain
  • Hospital Universitario 12 de Octubre
  • Madrid 28041 Spain
  • Hospital Universitario La Paz
  • Madrid 28046 Spain
  • Hospital Universitario HM Sanchinarro - CIOCC
  • Madrid 28050 Spain
  • Hospital Universitario Virgen del Rocio
  • Sevilla 41013 Spain
  • Fundacion Instituto Valenciano de Oncologia
  • Valencia 46009 Spain
  • APL
  • Stockholm 171 64 Sweden
  • Karolinska University Hospital
  • Stockholm 171 76 Sweden
  • ApoEx VN
  • Örebro 701 85 Sweden
  • Örebro University Hospital
  • Örebro 701 85 Sweden
  • Clinical Trial Pharmacy, China Medical University Hospital
  • Taichung 40447 Taiwan
  • China Medical University Hospital
  • Taichung 404 Taiwan
  • Clinical Trial Pharmacy, Taichung Veterans General Hospital
  • Taichung 407 Taiwan
  • Taichung Veterans General Hospital
  • Taichung 407 Taiwan
  • Department of Pharmacy, National Cheng Kung University Hospital
  • Tainan 704 Taiwan
  • National Cheng Kung University Hospital
  • Tainan 704 Taiwan
  • Investigational Drug services, National Taiwan University Hospital
  • Taipei 100 Taiwan
  • Koo Foundation Sun Yat-Sen Cancer Center
  • Taipei 112 Taiwan
  • Pharmacy, Koo Foundation Sun Yat-Sen Cancer Center
  • Taipei 112 Taiwan
  • National Taiwan University Hospital
  • Taipei Taiwan
  • Chang Gung Memorial Hospital, Linkou
  • Taoyuan 333 Taiwan
  • Chemotherapy pharmacy, Chang Gung Memorial Hospital, Linkou
  • Taoyuan 333 Taiwan
  • Churchill Hosptial
  • Headington Oxford OX3 7LJ United Kingdom
  • Royal United Hospitals Bath NHS Foundation Trust
  • Bath BA1 3NG United Kingdom
  • St Bartholomew 's Hospital, Barts Health NHS Trust
  • London EC1A 7BE United Kingdom
  • St. Bartholomew's Hospital, Barts Health NHS Trust
  • London EC1A 7BE United Kingdom
  • Guy's & St. Thomas' NHS Foundation Trust
  • London SE1 9RT United Kingdom
  • Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital
  • London SE1 9RT United Kingdom
  • Clinical Trials Aseptic Unit (CTASU) Churchill Hospital
  • Oxford, Oxfordshire OX3 7LE United Kingdom
  • Churchill Hospital, Oxford University Hospitals NHS Trust
  • Oxford OX3 7LE United Kingdom

View trial on ClinicalTrials.gov


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