I still remember the debates around treating sarcomatoid renal cell carcinoma (RCC) a decade ago when I started in practice. There were not many studies to cite – one that often came up was Naomi Haas’s trial of doxorubicin with gemcitabine (ECOG 8802). The study showed progression-free survival (PFS) of 3.5 months and overall survival (OS) of 8.8 months – sobering results, but at least an option we could pursue in the clinic. I only treated a handful of patients with this regimen, but it was certainly no walk in the park – massive fatigue, cytopenias and a range of other toxicities.
In February, we all waited with bated breath for the results of KEYNOTE-426 and updated results of JAVELIN-101, examining axitinib/pembrolizumab and axitinib/avelumab, respectively.1,2 In the coming months, we will juxtapose these datasets, and compare and contrast with what we know about nivolumab/ipilimumab from CheckMate-214 and cabozantinib from CABOSUN.3,4 These four trials have collectively changed the landscape of what used to be a simple algorithm for metastatic renal cell carcinoma (mRCC).
San Francisco has been hopping since the start of the new year, with multiple meetings causing tidal waves of change in oncology. The J.P. Morgan meeting was the first of these, showcasing multiple mergers and acquisitions in biotech and hinting towards major development efforts in CAR-T and BiTE technologies. ASCO GU came next, with stunning data for combinations of immune and targeted therapy in challenging diseases such as esophageal and gastric cancer.
The 2018 Society of Urologic Oncology (SUO) Meeting was second to none – an outstanding array of speakers and sessions that addressed virtually every salient point pertaining to renal cell carcinoma (RCC) treatment.  As you can imagine, cytoreductive nephrectomy was a hot topic for discussion – SUO 2018 marked the first large US
I’m back now from a short stay in Munich for ESMO 2018 – didn’t get much beer or bratwurst, but I did soak in as much of the meeting as I could. The conference spanned a full five days – a little too much for my clinical schedule to handle – but I did get my hands on the bulk of the important renal cell carcinoma (RCC) data from the meeting.  I’ve boiled it down to three brief bullet points:
When I finished training and joined the faculty at City of Hope a decade ago, there was a great deal of excitement over recent approvals of sunitinib and sorafenib for metastatic renal cell carcinoma (mRCC).  Throughout my training, I had seen many patients succumb to toxicities from interleukin-2 – despite the handful of victories, there were overwhelming losses. 
Welcome to the Advanced Kidney Cancer Center of Excellence on UroToday.com.  My name is Monty Pal, and I am a medical oncologist with just over a decade of experience in a research-based practice primarily focused on RCC and other genitourinary cancers.  I recall that when I began, our treatment options were limited.