Adrenal Diseases
Association between remnant cholesterol inflammation index and erectile dysfunction among U.S. adults: a cross-sectional study.
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C-reactive protein (CRP) and remnant cholesterol (RC) are two indicators that are included in the remnant cholesterol inflammation index (RCII). The purpose of this study is to assess the relationship between RCII and the likelihood of erectile dysfunction (ED).
Results from the ERAS for Ambulatory TURBT: Enhancing Bladder Cancer Care (EMBRACE) Randomized Controlled Trial.
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Transurethral resection of a bladder tumor (TURBT) contributes to morbidity of patients with bladder cancer. This trial evaluates the impact of an enhanced recovery after surgery (ERAS) protocol on quality of recovery from ambulatory TURBT.
Treatment of non-muscle-invasive bladder cancer.
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Non-muscle-invasive bladder cancer (NMIBC) is characterized by high rates of recurrence and progression, particularly in high-risk disease. Despite transurethral resection and adjuvant intravesical Bacillus Calmette-Guérin (BCG) therapy, a need for more effective bladder-preserving treatment strategies remains.
Evaluation of an Infection Control Management Mode for Preventing Catheter-Related Urinary Tract Infections in Intensive Care Units.
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This study explored an infection control management mode effect that prevents catheter-associated urinary tract infection (CAUTI) in an intensive care unit (ICU).
A retrospective cohort study was conducted on patients who received indwelling catheters from February 2020 to February 2022 in the ICU ward.
Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer.
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Cancers invoke various pathways to mitigate external and internal stresses to continue their growth and progression. We previously reported that the eIF2 kinase GCN2 and the integrated stress response are constitutively active in prostate cancer (PCa) and are required to maintain amino acid homeostasis needed to fuel tumor growth.
Ixazomib as consolidation and maintenance versus observation in patients with relapsed multiple myeloma eligible for salvage autologous stem-cell transplantation (Myeloma XII [ACCoRD]): interim analysis of a multicentre, open-label, randomised, phase 3 tr
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The efficacy of consolidation and maintenance in the context of salvage autologous haematopoietic stem-cell transplantation (HSCT) for relapsed multiple myeloma remains unclear. We aimed to assess whether consolidation after salvage autologous HSCT, using ixazomib, thalidomide, and dexamethasone, followed by maintenance with single agent ixazomib is superior to observation.
Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma.
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Prostate cancer has heterogeneous growth patterns, and its prognosis is the poorest when it progresses to a neuroendocrine phenotype. Using bioinformatic analysis, we evaluated RNA expression of neuroendocrine genes in a panel of five different cancer types: prostate adenocarcinoma, breast cancer, kidney chromophobe, kidney renal clear cell carcinoma and kidney renal papillary cell carcinoma.
LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer.
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Lysine-specific demethylase 1 (LSD1 or KDM1A ) has emerged as a critical mediator of tumor progression in metastatic castration-resistant prostate cancer (mCRPC). Among mCRPC subtypes, neuroendocrine prostate cancer (NEPC) is an exceptionally aggressive variant driven by lineage plasticity, an adaptive resistance mechanism to androgen receptor axis-targeted therapies.
Comparison of morbidity and mortality after radical cystectomy between individuals older and younger than 80 years: a systematic review and meta-analysis.
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To compare outcomes related to survival and post-operative complications in individuals older and younger than 80 years with bladder cancer undergoing radical cystectomy (RC).
We conducted a systematic search using three large databases: PubMed, EMBASE, and Scopus.
Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor.
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Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer, arising from resistance to androgen-deprivation therapies. However, the molecular mechanisms associated with NEPC development and invasiveness are still poorly understood.