Are Excessive Daytime Sleepiness and Lower Urinary Tract Symptoms the Triggering Link for Mental Imbalance? An Exploratory Post Hoc Analysis.

Both lower urinary tract symptoms (LUTS) and excessive daytime sleepiness (EDS) could negatively impair the patients' quality of life, increasing the sensitivity to psychological distress that results in mental health disorders. The relationships of both urinary and respiratory domains with psychological distress in obstructive sleep apnea patients is still underestimated.

This study was a post hoc analysis of a web-based Italian survey, which included 1998 participants. Three hierarchical multiple linear regression analyses with psychological distress as dependent variable were performed on the study of 1988 participants enrolled in the final analysis. Cohen's f2 was used for the assessment of the effect size.

From the hierarchical multiple linear regression analyses, it emerged that the final statistical model (including sociodemographic characteristics, comorbidities, perceived urinary function, and excessive daytime sleepiness) for all dimensions accounted for 16.7% of the variance in psychological distress, with a medium effect size (f2 = 0.15).

People reported psychological distress was impaired by the presence of LUTS and EDS. Specifically, our study showed that higher levels of distress were scored especially in young women exhibiting urinary symptoms and with high values of daytime sleepiness.

Journal of clinical medicine. 2023 Nov 07*** epublish ***

Francesco Di Bello, Cristiano Scandurra, Benedetta Muzii, Claudia Colla' Ruvolo, Gianluigi Califano, Edoardo Mocini, Massimiliano Creta, Luigi Napolitano, Simone Morra, Agostino Fraia, Vincenzo Bochicchio, Giovanni Salzano, Luigi Angelo Vaira, Francesco Mangiapia, Gaetano Motta, Giovanni Motta, Nelson Mauro Maldonato, Nicola Longo, Elena Cantone

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", 80131 Naples, Italy., Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy., Department of Humanistic Studies, University of Calabria, 87036 Rende, Italy., Maxillofacial Surgery Operative Unit, University Hospital of Naples "Federico II", 80131 Naples, Italy., Maxillofacial Surgery Operative Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., ENT Unit, Department of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.