Global Variations in the Mineral Content of Bottled Still and Sparkling Water and a Description of the Possible Impact on Nephrological and Urological Diseases.

Kidney stone disease (KSD) is a complex disease. Besides the high risk of recurrence, its association with systemic disorders contributes to the burden of disease. Sufficient water intake is crucial for prevention of KSD, however, the mineral content of water might influence stone formation, bone health and cardiovascular (CVD) risk. This study aims to analyse the variations in mineral content of bottled drinking water worldwide to evaluate the differences and describes the possible impact on nephrological and urological diseases. The information regarding mineral composition (mg/L) on calcium, bicarbonate, magnesium, sodium and sulphates was read from the ingredients label on water bottles by visiting the supermarket or consulting the online shop. The bottled waters in two main supermarkets in 21 countries were included. The evaluation shows that on a global level the mineral composition of bottled drinkable water varies enormously. Median bicarbonate levels varied by factors of 12.6 and 57.3 for still and sparkling water, respectively. Median calcium levels varied by factors of 18.7 and 7.4 for still and sparkling water, respectively. As the mineral content of bottled drinking water varies enormously worldwide and mineral intake through water might influence stone formation, bone health and CVD risk, urologists and nephrologists should counsel their patients on an individual level regarding water intake.

Journal of clinical medicine. 2021 Jun 27*** epublish ***

Simone J M Stoots, Guido M Kamphuis, Rob Geraghty, Liffert Vogt, Michaƫl M E L Henderickx, B M Zeeshan Hameed, Sufyan Ibrahim, Amelia Pietropaolo, Enakshee Jamnadass, Sahar M Aljumaiah, Saeed B Hamri, Eugenio Ventimiglia, Olivier Traxer, Vineet Gauhar, Etienne X Keller, Vincent De Coninck, Otas Durutovic, Nariman K Gadzhiev, Laurian B Dragos, Tarik Emre Sener, Nick Rukin, Michele Talso, Panagiotis Kallidonis, Esteban Emiliani, Ewa Bres-Niewada, Kymora B Scotland, Naeem Bhojani, Athanasios Vagionis, Angela Piccirilli, Bhaskar K Somani

Department of Urology, Amsterdam UMC, AMC, University of Amsterdam, 1105 Amsterdam, The Netherlands., Department of Urology, Freeman Hospital, Newcastle NE7 7DN, UK., Department of Internal Medicine, Section Nephrology, Amsterdam UMC, AMC, University of Amsterdam, 1105 Amsterdam, The Netherlands., Department of Urology, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India., Department of Urology, University Hospital Southampton NHS Trust, Southampton SO16 6YD, UK., Department of Urology, Ministry of the National Guard-Health Affairs, Riyadh 11426, Saudi Arabia., Division of Experimental Oncology/Unit of Urology, IRCCS Ospedale, Urological Research Institute, San Raffaele, 20132 Milan, Italy., Department of Urology, Sorbonne University, GRC #20 urolithiasis, 75006 Paris, France., Department of Urology, Ng Teng Fong General Hospital, Singapore 609606, Singapore., Department of Urology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland., Department of Urology, AZ Klina, 2930 Brasschaat, Belgium., Department of Urology, University Clinical Center of Serbia, University of Belgrade, 11000 Belgrade, Serbia., Department of Urology, Saint-Petersburg State University Hospital, 197022 Saint Petersburg, Russia., Department of Urology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK., Department of Urology, Marmara University Hospital, Marmara University School of Medicine, Istanbul 34854, Turkey., Department of Urology, Redcliff Hospital, Brisbane QLD 4012, Australia., Department of Urology, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, 20157 Milan, Italy., Department of Urology, University of Patras, 26504 Patras, Greece., Department of Urology, FundaciĆ³ Puigvert, Autonomous University of Barcelona, 08025 Barcelona, Spain., Department of Urology, Medical University of Warsaw, 02-091 Warsaw, Poland., Department of Urology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA., Department of Urology, University of Montreal, Montreal, QC H2X 0A9, Canada.