EAU 2008 - Advances in Targeted Therapy and Tissue Engineering in Urology: Targeted Therapy
Tuesday, 01 April 2008
MILAN, ITALY (UroToday.com) - When a patient comes to the pharmacist in the future he may state: “Here is my sequence”. This could be a consequence of the development of targeted therapies as presented by Chris Evans. He pointed out that molecular profile of a patient will have an increasing impact on the selection patients for a diagnostic procedure or even a specific therapy.
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EAU 2008 - Advances in Targeted Therapy and Tissue Engineering in Urology
Tuesday, 01 April 2008
MILAN, ITALY (UroToday.com) - Dr. Evans (Sacramento) presented a lecture on targeted therapies. Most drugs have a mechanistic “target”, such as the enzymes 5-α reductase in the treatment of BPH or 5-phosphodiesterase in the treatment of erectile dysfunction. However, in the current presentation, “targeted therapy” is defined as molecular targeting.
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EAU 2008 - Combined Targeting of Androgen Receptor and Protein Kinase A Signaling Pathways Increase Inhibition of Prostate Tumor Growth
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - In the androgen ablation-resistant stage of prostate cancer, androgen receptor (AR) activation may occur through ligand-independent interaction of AR with other signaling pathways, including protein kinase A (PKA).
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EAU 2008 - The Use of Biological Markers in Clinical Practice
Tuesday, 01 April 2008
MILAN, ITALY (UroToday.com) - Dr. Bjartell (Lund) presented on the use of biological markers as they can apply to clinical practice. A useful biomarker, he said is a molecular test that provides additional information to clinical information.
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EAU 2008 - Operative Complications of Robotic-Assisted Radical Prostatectomy
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - This group from Ohio State reviewed their experience of radical robotic prostatectomy (RALP) in over 1800 cases.
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EAU 2008 - Quantitative Analysis of Tumor Cell Burden in Metastatic Prostate Cancer Using Lymph Node Disintegrates
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Detection of micrometastases by conventional histology requires extensive serial step sectioning and immunohistochemical staining.
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EAU 2008 - Molecular Detection of Lymph Node Involvement in Genitourinary Cancer
Tuesday, 01 April 2008
MILAN, ITALY (UroToday.com) - Dr. Michael Jewett (Toronto) presented the SIU lecture on detection and mapping regional lymph nodes (LN) in genitourinary cancer. He addressed the importance of LN in staging and therapy of GU cancers.
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EAU 2008 - Feasibility of Prostate Cancer Detection by Triple Spectroscopy
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Dr. Salomon discussed how a positive surgical margin (PSM) following radical prostatectomy (RP) is known to be an adverse factor for recurrence free survival.
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EAU 2008 - Advanced Age Predisposes to Higher Rate of Biochemical Recurrence After Radical Prostatectomy
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - The efforts towards an earlier prostate cancer (PCa) diagnosis led to a decrease in the mean age in PCa detection, which in turn translated into younger men treated with radical prostatectomy (RP) and more localized stage at RP. This work hypothesized that the age at RP maybe an independent predictor of biochemical recurrence (BCR) after RP.
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EAU 2008 - Screening Interval in Men with an Abnormal Digital Rectal Examination in a Randomized Study of Screening for Prostate Cancer
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - European Randomized Study of Screening for Prostate Cancer
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EAU 2008 - Does Blood Volume have an Impact on Serum PSA Levels?
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Serum PSA is influenced by a number of factors such as prostate volume, acute/chronic prostatitis, manipulation, sexual activity etc.
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EAU 2008 - The Number of Positive Cores for HGPIN on First Biopsy Predicts the Risk of Prostate Cancer on Second Biopsy
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - High grade prostatic intraepithelial neoplasia (HGPIN) has been reported between 0.7 and 24% in biopsy samples with a 23 to 79% risk of finding carcinoma on subsequent biopsy.
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EAU 2008 - Chronic Inflammation of the Prostate as a Risk Factor for Prostate Cancer: A 4-Year Follow Up Study
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Chronic inflammation of the prostate has frequently been identified in biopsies based on PSA elevation.
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EAU 2008 - Zoledronic Acid for the Prevention of Bone Metastases in High-Risk Prostate Cancer Patients
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - A randomized, open label, multicenter study of the European Association of Urology (EAU) in cooperation with the Scandinavian Prostate Cancer Group (SPCG) and the Arbeitsgemeinschaft Urologische Onkologie (AUO)
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EAU 2008 - Chemotherapy and New Concepts in Hormone-Refractory Prostate Cancer
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Is intermittent docetaxel chemotherapy reasonable in hormone refractory prostate cancer? A prospective randomized study
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EAU 2008 - A Multi-Institutional Cohort of Active Surveillance for Low-Risk Localized Prostate Cancer
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Active surveillance (AS) is a rationale and increasingly common management strategy.
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EAU 2008 - Anxiety in Men on Active Surveillance for Early Prostate Cancer
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Active surveillance (AS) for early prostate cancer (PC) has received increasing attention because it may reduce over-treatment of screen-detected PC. It is assumed that this management option preserves quality of life by avoiding the possible negative side effects of radical treatment.
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EAU 2008 - Potency Rates Following Radical Prostatectomy are Improved by Preservation of the Tip of the Seminal Vesicle
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - The group from Vienna, Austria evaluated the legacy and impact of preservation of the tip of the seminal vesicle during radical retropubic prostatectomy on potency and continence rates.
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EAU 2008 - Sutureless Vesico-Urethral Anastomosis After Radical Prostatectomy: Initial Clinical Feasibility Data from the Continuum™ Study
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Continuum™ (American Medical Systems Inc.) is a novel surgical device designed to facilitate the approximation of the bladder neck and urethral stump during radical prostatectomy (RP) without sutures.
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EAU 2008 - Prostate Cancer Progression Identified by Promoter Hypermethylation in Circulating Blood Cells
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Professor Hamdy's group presented work regarding promoter hypermethylation of circulating cell DNA, which has been advocated as a diagnostic marker for prostate cancer. Its prognostic use is currently unclear.
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EAU 2008 - Improvements in the Diagnosis and Prognosis of Prostate Cancer
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - TMPRSS2:ERG rearrangement is an independent marker of good prognosis in prostate cancer
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EAU 2008 - Optimal Sampling Sites for Initial and Repeat Prostate Biopsy
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - A recursive partitioning analysis of 24-core systematic biopsy
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EAU 2008 - Tumor Characteristics in Screen Detected and Clinically Diagnosed Prostate Cancers (in the European Randomized Study of Screening for Prostate Cancer)
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Intermediate endpoints of prostate cancers detected in the European randomized study of screening for prostate cancer, section Rotterdam
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EAU 2008 - Novel Therapies in Prostate Cancer: Nano-Scaled Containers for Drug Delivery
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Carbon Nanotubes: A Nanocontainer Mediates Transport of Chemotherapeutics
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EAU 2008 - A New Option for Neovascular Targeting in the Treatment of Prostate Cancer
Friday, 04 April 2008
MILAN, ITALY (UroToday.com) - Paclitaxel Encapsulated in Cationic Liposomes: A New Option for Neovascular Targeting for the Treatment of Prostate Cancer
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EAU 2008 - Identification of Prostate Cancer Susceptibility Loci
Monday, 31 March 2008
MILAN, ITALY (UroToday.com) - Dr. Kiermeney (Nijmegen) presented data on susceptibility loci in prostate cancer (CaP). Searching for genes in this setting can be done by looking for functional variants of genes suspected to be involved. Linkage studies in high-risk families look for co-segregation of markers and search for closely located genes.
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EAU 2008 - Gene Fusion and the Development of Drug Targets in Prostate Cancer
Monday, 31 March 2008
MILAN, ITALY (UroToday.com) - Dr. Mark Rubin spoke on gene fusion and the development of drug targets. A common, recurrent gene fusion between the TMPRSS2 and ETS transcription factor occurs in prostate cancer (CaP).
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EAU 2008 - Case Discussion: The Role of Lymphandectomy in Early Prostate Cancer
Monday, 31 March 2008
MILAN, ITALY (UroToday.com) - A case discussion took place at the plenary session at the EAU meeting. It addressed the role of lymphadenectomy (LA) in prostate cancer (CaP). Professor Tombal (Brussels) chaired the session that included Drs. Studer (Berne), Touijer (NY), Wechermann (Augsburg), and Wiegel (Ulm).
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EAU 2008 - Pim-1 as a Potential Oncogene in the Progression of Prostate Cancer
Monday, 31 March 2008
MILAN, ITALY (UroToday.com) - Dr. Van Der Poel from the National Cancer Institute, Netherlands presented a poster on Pim-1, a serine threonine kinase that has been associated with the progression of prostate cancer as a potential oncogene.
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EAU 2008 - Increased Migration Inhibitory Factor (MIF) Secretion by Neuroendocrine Differentiated LNCaP Cells Induces Proliferation and Survival of Prostate Cancer Cells
Monday, 31 March 2008
MILAN, ITALY (UroToday.com) - The poster presented data regarding macrophage migration inhibitory factor (MIF), initially identified as a pro-inflammatory cytokine expressed at baseline in numerous cell types and tissues.
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Conference Coverage 
